The brand is Jarrow methylb12.
They take like forever to dissolve and I hate having them in my mouth.
Can I just swallow them?
Posted 12 August 2011 - 11:47 PM
Posted 13 August 2011 - 01:02 AM
Posted 04 September 2011 - 04:04 PM
Posted 04 September 2011 - 04:33 PM
Posted 06 September 2011 - 02:25 PM
Posted 13 September 2011 - 05:12 PM
Posted 10 November 2011 - 07:47 PM
Edited by Brainfogged, 10 November 2011 - 07:48 PM.
Posted 10 November 2011 - 09:57 PM
Posted 11 November 2011 - 03:57 AM
I dont get why some supp need to be sublingual in the first place. I'm taking Glycine and Methylcobalamin sublingually. I wish I could just swallow them.
When a chemical comes in contact with the mucous membrane beneath the tongue, or buccal mucosa, it diffuses through it. Because the connective tissue beneath the epithelium contains a profusion of capillaries, the substance then diffuses into them and enters the venous circulation. In contrast, substances absorbed in the intestines are subject to "first pass metabolism" in the liver before entering the general circulation.
Sublingual administration has certain advantages over oral administration. Being more direct, it is often faster, and it ensures that the substance will risk degradation only by salivary enzymes before entering the bloodstream, whereas orally administered drugs must survive passage through the hostile environment of the gastrointestinal tract, which risks degrading them, either by stomach acid or bile, or by the many enzymes therein, such as monoamine oxidase (MAO). Furthermore, after absorption from the gastrointestinal tract, such drugs must pass to the liver, where they may be extensively altered; this is known as the first pass effect of drug metabolism. Due to the digestive activity of the stomach and intestines and the solubility of the GI tract, the oral route is unsuitable for certain substances, such as salvinorin A.
Without affecting absorption? Then what's the point of a sublingual dosage form?I mailed Jarrow about this, here is their answer.
Subject: RE: Methyl B12 5000mcg?
Thanks for your inquiry, Brainfogged. Yes, Methyl B12 may be swallowed whole without affecting absorption.
Ken
Tech support
Posted 11 November 2011 - 04:37 AM
Even though both of these studies administered methylcobalamin intravenously, evidence suggests that oral methylcobalamin is just as effective. Look for supplements designed to be taking sublingually since methylcobalamin may degrade if digested.
Posted 11 November 2011 - 04:59 AM
Posted 11 December 2011 - 01:12 AM
I dont get why some supp need to be sublingual in the first place. I'm taking Glycine and Methylcobalamin sublingually. I wish I could just swallow them.
Wikipedia describes it as:When a chemical comes in contact with the mucous membrane beneath the tongue, or buccal mucosa, it diffuses through it. Because the connective tissue beneath the epithelium contains a profusion of capillaries, the substance then diffuses into them and enters the venous circulation. In contrast, substances absorbed in the intestines are subject to "first pass metabolism" in the liver before entering the general circulation.
Sublingual administration has certain advantages over oral administration. Being more direct, it is often faster, and it ensures that the substance will risk degradation only by salivary enzymes before entering the bloodstream, whereas orally administered drugs must survive passage through the hostile environment of the gastrointestinal tract, which risks degrading them, either by stomach acid or bile, or by the many enzymes therein, such as monoamine oxidase (MAO). Furthermore, after absorption from the gastrointestinal tract, such drugs must pass to the liver, where they may be extensively altered; this is known as the first pass effect of drug metabolism. Due to the digestive activity of the stomach and intestines and the solubility of the GI tract, the oral route is unsuitable for certain substances, such as salvinorin A.Without affecting absorption? Then what's the point of a sublingual dosage form?I mailed Jarrow about this, here is their answer.
Subject: RE: Methyl B12 5000mcg?
Thanks for your inquiry, Brainfogged. Yes, Methyl B12 may be swallowed whole without affecting absorption.
Ken
Tech support
Posted 12 December 2011 - 08:08 PM
Posted 13 December 2011 - 05:20 AM
Edited by hyper_ventriloquism, 13 December 2011 - 05:22 AM.
Posted 13 December 2011 - 09:59 PM
Without affecting absorption? Then what's the point of a sublingual dosage form?
I thought about this also.
Maybe sublingual has an direct effect whilst ingesting takes more time for the body to build up B12. I dont know, I hope someone can give us a better answer.
Posted 14 December 2011 - 01:02 AM
Posted 14 December 2011 - 03:52 AM
Is it common for people to be unable to convert either cyano- or hydroxocobalamin to the methyl form?My understanding was that the point is for the neurons/brain to directly use the form methylcobalamin instead of having to synthesize it itself:
http://hansref.blogs...-brain-b12.html (note: this is my blog post btw).
Posted 14 December 2011 - 03:58 AM
Edited by Sillewater, 14 December 2011 - 04:17 AM.
0 members, 1 guests, 0 anonymous users