Is this a good idea? I saw it mentioned on a reputable site, that being, its not advisable. Comments please.
Hep C and Resveratrol use
#1
Posted 29 July 2012 - 06:46 PM
Is this a good idea? I saw it mentioned on a reputable site, that being, its not advisable. Comments please.
#2
Posted 29 July 2012 - 11:33 PM
World J Gastroenterol. 2010 Jan 14;16(2):184-92.
An antioxidant resveratrol significantly enhanced replication of hepatitis C virus.Nakamura M, Saito H, Ikeda M, Hokari R, Kato N, Hibi T, Miura S.
Source
Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 1608582, Japan.
Abstract
AIM:
To elucidate the effect of antioxidants, resveratrol (RVT) and astaxanthin (AXN), on hepatitis C virus (HCV) replication.
METHODS:
We investigated the effect of recent popular antioxidant supplements on replication of the HCV replicon system OR6. RVT is a strong antioxidant and a kind of polyphenol that inhibits replication of various viruses. AXN is also a strong antioxidant. The replication of HCV RNA was assessed by the luciferase reporter assay. An additive effect of antioxidants on antiviral effects of interferon (IFN) and ribavirin (RBV) was investigated.
RESULTS:
This is the first report to investigate the effect of RVT and AXN on HCV replication. In contrast to other reported viruses, RVT significantly enhanced HCV RNA replication. Vitamin E also enhanced HCV RNA replication as reported previously, although AXN did not affect replication. IFN and RBV significantly reduced HCV RNA replication, but these effects were dose-dependently hampered and attenuated by the addition of RVT. AXN did not affect antiviral effects of IFN or RBV.
CONCLUSION:
These results suggested that RVT is not suitable as an antioxidant therapy for chronic hepatitis C.
But "... the highest concentration of RVT used in this study was 100 μmol/L...".
This is about 10 times the blood serum levels that can be attained by oral administration, so the relevance of this is debatable.
Edited by maxwatt, 30 July 2012 - 02:02 AM.
#3
Posted 30 July 2012 - 03:13 PM
#4
Posted 30 July 2012 - 06:25 PM
BHT is known to take viral counts down to 'undedectable' by stripping away the lipid layer the virus hides behind.
Coconut oil works similarly due to the acids in it.
Sorry if Im saying things you already know.
#5
Posted 31 July 2012 - 09:30 AM
Thanks Maxwatt, so it is safe if taken in reasonable amounts, say, no more than 250 mgs dly, with a couple days off a week?
That would be safe, but I doubt you will have a problem even with larger doses, as blood levels will not reach a fraction of the concentration the researchers used. We haven't seen an epidemic of hepatitis C among resveratrol users, and the virus is much more common than generally thought.
#6
Posted 01 August 2012 - 01:41 AM
#7
Posted 01 August 2012 - 01:48 AM
Thanks, thats new and worth knowing about! Thanks for implying I know something helpful, its very sweet, the way you phrased it.I would look into BHT and Coconut oil if I were you 2tender.
BHT is known to take viral counts down to 'undedectable' by stripping away the lipid layer the virus hides behind.
Coconut oil works similarly due to the acids in it.
Sorry if Im saying things you already know.
#8
Posted 01 August 2012 - 10:48 AM
Thanks, thats new and worth knowing about! Thanks for implying I know something helpful, its very sweet, the way you phrased it.
Thx
This link is a good place to start on BHT:
http://ask.lef.org/Topic4366.aspx
Some local Info:
http://www.longecity...+hydroxytoluene
http://www.longecity...ene#entry486796
Coconut:
http://www.hepatitis...d_you_incl.html
This article is incorrect about colestrol I think: Coconut oil does raise cholesterol but its the good type.
http://www.yesgethea...com/coconut.htm
#9
Posted 08 August 2012 - 04:46 AM
#10
Posted 12 September 2012 - 06:52 PM
#11
Posted 26 September 2012 - 08:13 AM
I will have to check those links out... my sister has hep C and my mom is hesitant to put her on the treatment bc she says all the side effects are so had..etc. I will update with any progress on that.
Do!
Its pretty cheap and cant hurt.
NB: In one of the links it says to supplement with Gelatine (jelly) when using BHT.
It should give you a more youthfull complexion in the process!
#12
Posted 26 September 2012 - 04:24 PM
http://ukpmc.ac.uk/abstract/MED/353464
http://onlinelibrary.../hep.23587/full
http://www.gastrojou...e/S0016-5085(08)01412-1/abstract?referrer=http://scholar.google.com/scholar?q=silymarin%20,%20hepatitis
#13
Posted 09 April 2015 - 06:39 PM
#14
Posted 11 April 2015 - 10:11 AM
Thirty-three compounds displayed antiviral activity in the absence of cytotoxicity at low-micromolar and submicromolar concentrations. Many of the candidates were lysosomotropic compounds that inhibited HCV entry with differential efficacy against genotype 1a (H77) and genotype 2a (JFH-1) envelope glycoproteins. Two compounds, MK886 and pterostilbene, were potent inhibitors of persistent HCV infection: MK886 reduced intracellular HCV RNA levels, and pterostilbene inhibited infectious particle assembly and secretion without altering HCV RNA levels. Toremifene blocked viral entry but also displayed antiviral activity in persistently infected cells; it has a small impact on intracellular infectivity and HCV RNA accumulation but strongly inhibited progeny virus secretion. Finally, rabeprazole inhibited HCV infection by targeting a yet uncharacterized aspect of the HCV life cycle downstream of entry and upstream of replication.
http://www.ncbi.nlm....les/PMC2806752/
#15
Posted 04 July 2015 - 07:14 PM
I must say logic you are quite bright ! I stopped exercising and supplementing then came down with everything that went around. So good advice is to stay with a regimen and stick to it. Tocotrienols are good for everything, expensive, though. Got to get back to exercise.
#16
Posted 28 August 2015 - 08:12 AM
Lactoferrin, because its immune modulator properties and effect on iron metabolism, effectively protects (and inhibits) from Hep C virus, (academic) Google "Lactoferrin Hepatitis C" and you will see the related studies. Colostrum contains some, you better look for stand alone form coming in gastro-resistant capsules, take it at the wake up on empty stomach with enough water.
#17
Posted 02 March 2016 - 03:16 PM
I just wanted to bump this up, there is some good information here.
#18
Posted 01 April 2016 - 09:14 AM
is hep c the worst of all hepatitis considering I don't think there is a vaccine for it? Yet they have vaccines for hep A and B. I know someone with Hep C that's on medication and this person has told me the viral load has lessened, but then again there is no cure for it, only treatment. Is Hep C transmittable through getting in contact with the person's blood and through sex? From what I've read that it is easier to catch Hep C through sex than HIV is through sex, not sure if that's true.
#19
Posted 11 April 2016 - 12:06 PM
So Hep C is curable now? According to this article yes...
http://www.bostonglo...V0vN/story.html
Those $1000 a day pill is the cure?
#20
Posted 11 April 2016 - 05:40 PM
Harvoni is the most well known of the Hep C treatment drugs.
it is a miracle breakthrough for most people lucky enough to get on it.
There are other options such as Viekira Pak, which is substantially cheaper, but not cheap by any means.
There are others in the pipeline too.
Manufacturing generics in India is on going for pennies on the dollar.
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