This is an old post so I hope someone sees it... I have pretty bad tinnitus and hyperacusis and after trying many natural alternatives as well as prescription meds, I figured I would give this a try after some hesitation. Only took 25mg today (first dose) which gives me a slight grogginess. Would like to give it a fair try by moving up to 50mg over the next few days. My question is, what about Selegiline to counter some of the grogginess and improve concentration? I feel like they we would be a good match in terms of evening each other out - and the Lyrica would help with potential Selegiline insomnia. Let me know if anyone has any thoughts/comments on this. Thanks people.
Pregabalin (lyrica), against TINNITUS?
I honestly DON'T think it's a good idea to add Selegiline to counter the cognitive effects of Lyrica - I'd recommend you simply use an anxiolytic drug that DOESN'T f*ck with your cognition to the same extent.
On the other hand, you're using Pregabalin for Tinnitus? Never heard of this... it's not something I'm familiar with - what's the basis for this? What effects does it have? Is it simply similar to the effects on chronic neural pain? I.e it generally slows down every single type of signal, eventually slowing down the faulty aural signalling as well? Now that I think about it... I guess that's it - it's essentially the same thing as with chronic pain from nerve-damage.
I'd recommend you try Memantine instead - NMDA-antagonists have been proven to both have anxiolytic effects, but also effects on tinnitus.
Of course, Memantine will cause somewhat similar negative effects as Pregabalin at first - BUT... unlike gabapentinoids, it's not habit-forming, and the negative effects on cognition will go away after a while.
Another idea, after a quick look at hyperacusis - is that there's at least one theory which believes it's connected to errors within serotonergic networks - well, SNRI's have been dubbed as the most effective long-term treatment of Anxiety, and they also have an effect on chronic pain - so yeah, might want to consider DULOXETINE, yes?
Here's actually a random guy on a tinnitus-forum whom sings its praises:
https://www.tinnitus...sis.7189/page-2