LongeCity . Advocacy & Research for Unlimited Lifespans
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Fight Aging News
Proposing that CK2.3 Treatment Can Restore Bone Density in Osteoporosis
Two populations of cells work on maintaining bone...
Today, 12:26 PM Read Full Story
Inovium Ovarian Rejuvenation Trials
The trial will be held at the Center for Advanced...
Today, 02:23 AM Read Full Story
Reassessing Past Evidence for Radiation Hormesis to Extend Life in Dogs
It is well known that induction of low or intermi...
Today, 12:22 AM Read Full Story
The Current State of Senolytic Drug Candidates
Here, find an examination of the current state of...
Yesterday, 01:17 PM Read Full Story
A Look at Some Recent Efforts to Push Rapamycin Derivatives to the Clinic
Rapamycin, its derivatives such as everolimus, an...
Yesterday, 12:43 PM Read Full Story
RepliCel’s Successful RCT-01 Tendon Repair Clinical Trial Shows Signs of Healing Chronic Tendon Problems
Yesterday, 02:12 AM Read Full Story
review: LongeCity Crowdfunded Research Projects
Longecity’s approach to supporting scientific research has always been characterized
by small-scale, high-impact projects sourced and steered by and in connection with its community. Years before ‘crowdfunding’ and ‘citizen science’ became well known concepts they were
practiced at LongeCity.
Some examples of SCIENCE projects we have crowdsourced in the past:
|“Laser ablation of lipofuscin”
 Lead: N.Schooler (SENS/private). An attempt to use medical lasers to eliminate Alzheimer plaques, this was an early venture in Longecity crowdfunding. While results were not of satisfactory robustness, this project paved the way towards LongeCity taking a planned approach to quality control in community crowdfunding science. [More info]
 Lead: Dr. J.Gruber (Singapore). Modulation of the incomplete coupling of electron transfer to ATP synthesis across the mitochondrial membrane has been proposed as a mechanism to slow aging. The project investigated this hypothesis in worms.
“Adult stem cells versus Alzheimer's”
 Lead: Dr. A.Stolzing (Germany). Aiming to use adult stem cells in the fight against age-related neurodegeneration such as Alzheimer's disease. Perhaps the most ambitious LongeCity funded project to date. [Publication]
 Lead: Dr. JP de Magalhães (UK). The innate toxicity of compounds used to protect against freezing damage limits their use for advancing the science of medical biostasis. Longecity crowdfunding helped generate new insights from gene expression profiling of endothelial cells exposed to ethylene glycol, thus helping to reveal molecular signatures helpful for future experiments on cryoprotectant toxicity [Publication]
“Mitochondria gene therapy”
 Lead: Dr. M.O’Connor (SENS). Another perspective at the crucial role of mitochondria in aging, this project supported research into rejuvenating these ‘power plants’ of the cell. $21K was mobilized and lead directly to a much larger follow-up project
|“Buckyballs & cancer”
 Lead: Dr. K.Moody (Ichor), the Longecity community got very intrigued about a research paper reporting to extend mouse lifespan with nanosize C60 ‘buckyballs’. Via crowdsourcing we promoted further independent investigation into C60 effects which, as a side effect also prompted some interesting vendor testing data.
|In addition to these specific research projects,
⇒ supported students via small grants,
⇒ established a research partnership and support strategy
⇒ taken the same crowdsourcing approach to other community initiatives.