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	<title>ImmInst Active Topics</title>
	<description></description>
	<link>http://www.longecity.org/forum</link>
	<pubDate>Sat, 25 May 2013 10:16:17 +0000</pubDate>
	<ttl>5</ttl>
	<image>
		<title>ImmInst Active Topics</title>
		<url>http://imminst.org/images/imminst_g.png</url>
		<link>http://www.longecity.org/forum</link>
	</image>
	<item>
		<title><![CDATA[Alzheimer's delaying stack?]]></title>
		<link>http://www.longecity.org/forum/topic/63763-alzheimers-delaying-stack/</link>
		<description><![CDATA[What would you include in a stack whose purpose was to delay the onset of Alzheimer's in the elderly? There are too many things out there that might help, what would you do? I was thinking about the following:<br />
<br />
- High dose curcumin<br />
- Green tea extract<br />
- Fish oil, olive oil and coconut oil<br />
- A good multi with enough B-vitamins<br />
<br />
What else?]]></description>
		<pubDate>Sat, 25 May 2013 10:16:17 +0000</pubDate>
		<guid>http://www.longecity.org/forum/topic/63763-alzheimers-delaying-stack/</guid>
	</item>
	<item>
		<title>Which supplier? - Canadian wishing to buy Piracetam</title>
		<link>http://www.longecity.org/forum/topic/63761-which-supplier-canadian-wishing-to-buy-piracetam/</link>
		<description><![CDATA[This is my first post on Longecity. I have been searching for new ways to improve cognitive function through new diets for a while now and recently got my self interested in trying different supplements. Along my search, I have been using Longecity as one of my main sources to learn about the supplements that I'm interested in. Hence, why I am posting here. I am a beginner in this area and have some questions about determining which supplier I should buy from. I may have missed some posts on this forum while searching for answers, so bare with me.<br />
<br />
I have tried purchasing Piracetam from Hard Rhino which redirected me to TheAminoStore. Since I live in Canada, the store checkout at TheAminoStore says I cannot purchase this item.<br />
<strong class='bbc'>Q1: Will I have any trouble getting supplements like Piracetam across my country's customs if I buy from Cerebral Health or New Star Nootropics?</strong><br />
<strong class='bbc'>Q2: If yes, which suppliers should I go to for these supplements if I live in Canada.</strong><br />
<strong class='bbc'>Q3: If no, what is the expected shipping eta to Canada if I go with Cerebral Health? New Star has the shipping faq on their website.</strong><br />
<br />
Thank you in advance for answering my questions.]]></description>
		<pubDate>Fri, 24 May 2013 22:42:25 +0000</pubDate>
		<guid>http://www.longecity.org/forum/topic/63761-which-supplier-canadian-wishing-to-buy-piracetam/</guid>
	</item>
	<item>
		<title>im ERLAFiN</title>
		<link>http://www.longecity.org/forum/topic/63759-im-erlafin/</link>
		<description>and im just passing through, dont mind me for now</description>
		<pubDate>Fri, 24 May 2013 18:31:33 +0000</pubDate>
		<guid>http://www.longecity.org/forum/topic/63759-im-erlafin/</guid>
	</item>
	<item>
		<title>Women using Saw Palmetto to Treat AGA Hair Thinning</title>
		<link>http://www.longecity.org/forum/topic/63758-women-using-saw-palmetto-to-treat-aga-hair-thinning/</link>
		<description><![CDATA[I have been experiencing or simply noticing hair miniaturization in the past 4 months most likely due to early thyroid problems and health stress over the past 2 years (now resolved though), and am wondering if there is a way to reverse or simply stop the miniaturization process. Basically, the root of my hair is significantly thinner, lighter (blonde), and weaker than the bottom (old) part of my hair, which is much thicker, darker (deep red), and stronger. I'm guessing in a couple of years my entire head will be like the root, unless I take measures to stop it now (or not). From what I understand Saw Palmetto is a natural way to prevent the conversion of testosterone to DHT and a mild anti-androgen. Could this prevent any further loss? Have any of you seen changes after using it? I refuse to take rogaine or propecia, or any other form of aggressive hair loss treatments as I had a very bad experience with Rogaine a year ago. I am taking Viviscal (500 plus reviews on amazon, 4.5 stars), but have only taken it for 2 weeks, so have not yet reaped the benefits. I took Saw Palmetto a few years ago, which didn't cause any bad side effects in me. Any thoughts/suggestions would be very helpful. Thanks!]]></description>
		<pubDate>Fri, 24 May 2013 18:02:51 +0000</pubDate>
		<guid>http://www.longecity.org/forum/topic/63758-women-using-saw-palmetto-to-treat-aga-hair-thinning/</guid>
	</item>
	<item>
		<title><![CDATA[Bexarotene, He's Here to Help .. again]]></title>
		<link>http://www.longecity.org/forum/topic/63757-bexarotene-hes-here-to-help-again/</link>
		<description><![CDATA[<strong class='bbc'>I am searching the study reference.</strong><br />
<br />
For the moment I only have this:<br />
<a href='http://www.upmc.com/media/NewsReleases/2013/Pages/pitt-research-drug-reverses-alzheimers-disease-mice.aspx' class='bbc_url' title='External link' rel='nofollow external'>http://www.upmc.com/...sease-mice.aspx</a><br />
<br />
reprint:<br />
<br />
<br />
<strong class='bbc'>	Drug Reverses Alzheimer&rsquo;s Disease Deficits in Mice, Pitt Research Confirms</strong><br />
<br />
<span style='color: #4E565A'><span style='font-family: Arial, Helvetica, sans-serif'><span style='font-size: 12px;'><strong class='bbc'>PITTSBURGH, May 23, 2013 </strong>&ndash; An anti-cancer drug reverses memory deficits in an Alzheimer&rsquo;s disease mouse model, <a href='http://www.publichealth.pitt.edu/' class='bbc_url' title='External link' rel='nofollow external'>University of Pittsburgh Graduate School of Public Health</a> researchers confirm in the journal <em class='bbc'><a href='http://www.sciencemag.org/' class='bbc_url' title='External link' rel='nofollow external'>Science</a></em>.</span></span></span><br />
<br />
<span style='color: #4E565A'><span style='font-family: Arial, Helvetica, sans-serif'><span style='font-size: 12px;'>The research, funded by the <a href='http://www.nia.nih.gov/' class='bbc_url' title='External link' rel='nofollow external'>National Institutes of Health&rsquo;s National Institute on Aging</a> and <a href='http://www.alz.org/' class='bbc_url' title='External link' rel='nofollow external'>Alzheimer&rsquo;s Association</a>, reviewed previously published findings on the drug bexarotene, approved by the <a href='http://www.fda.gov/' class='bbc_url' title='External link' rel='nofollow external'>U.S. Food and Drug Administration</a> for use in cutaneous T cell lymphoma. The Pitt Public Health researchers were able to verify that the drug does significantly improve cognitive deficits in mice expressing gene mutations linked to human Alzheimer&rsquo;s disease, but could not confirm the effect on amyloid plaques.</span></span></span><br />
<br />
<span style='color: #4E565A'><span style='font-family: Arial, Helvetica, sans-serif'><span style='font-size: 12px;'>&ldquo;We believe these findings make a solid case for continued exploration of bexarotene as a therapeutic treatment for Alzheimer&rsquo;s disease,&rdquo; said senior author Rada Koldamova, M.D., Ph.D., associate professor in <a href='http://www.eoh.pitt.edu/' class='bbc_url' title='External link' rel='nofollow external'>Pitt Public Health&rsquo;s Department of Environmental and Occupational Health</a>.</span></span></span><br />
<br />
<span style='color: #4E565A'><span style='font-family: Arial, Helvetica, sans-serif'><span style='font-size: 12px;'>Dr. Koldamova and her colleagues were studying mice expressing human Apolipoprotein E4 (APOE4), the only established genetic risk factor for late-onset Alzheimer&rsquo;s disease, or APOE3, which is known not to increase the risk for Alzheimer&rsquo;s disease, when a <a href='http://www.ncbi.nlm.nih.gov/pubmed/22323736' class='bbc_url' title='External link' rel='nofollow external'>Case Western Reserve University</a> study was published last year stating that bexarotene improved memory and rapidly cleared amyloid plaques from the brains of Alzheimer&rsquo;s model mice expressing mouse Apolipoprotein E (APOE). Amyloid plaques consist of toxic protein fragments called amyloid beta that seem to damage neurons in the brain and are believed to cause the associated memory deficits of Alzheimer&rsquo;s disease and, eventually, death.</span></span></span><br />
<br />
<span style='color: #4E565A'><span style='font-family: Arial, Helvetica, sans-serif'><span style='font-size: 12px;'>Bexarotene is a compound chemically related to vitamin A that activates Retinoic X Receptors (RXR) found everywhere in the body, including neurons and other brain cells. Once activated, the receptors bind to DNA and regulate the exp<b></b>ression of genes that control a variety of biological processes. Increased levels of APOE are one consequence of RXR activation by bexarotene. The Pitt researchers began studying similar compounds a decade ago.</span></span></span><br />
<br />
<span style='color: #4E565A'><span style='font-family: Arial, Helvetica, sans-serif'><span style='font-size: 12px;'>&ldquo;We were already set up to repeat the Case Western Reserve University study to see if we could independently arrive at the same findings,&rdquo; said co-author Iliya Lefterov, M.D., Ph.D., associate professor in Pitt Public Health&rsquo;s Department of Environmental and Occupational Health. &ldquo;While we were able to verify that the mice quickly regained their lost cognitive skills and confirmed the decrease in amyloid beta peptides in the interstitial fluid that surrounds brain cells, we did not find any evidence that the drug cleared the plaques from their brains.&rdquo;</span></span></span><br />
<br />
<span style='color: #4E565A'><span style='font-family: Arial, Helvetica, sans-serif'><span style='font-size: 12px;'>The Pitt researchers postulate that the drug works through a different biological process, perhaps by reducing soluble oligomers which, like the plaques, are composed of the toxic amyloid beta protein fragments. However, the oligomers are composed of smaller amounts of amyloid beta and, unlike the plaques, are still able to &ldquo;move.&rdquo;</span></span></span><br />
<br />
<span style='color: #4E565A'><span style='font-family: Arial, Helvetica, sans-serif'><span style='font-size: 12px;'>&ldquo;We did find a significant decrease in soluble oligomers,&rdquo; said Dr. Koldamova. &ldquo;It is possible that the oligomers are more dangerous than the plaques in people with Alzheimer&rsquo;s disease. It also is possible that the improvement of cognitive skills in mice treated with bexarotene is unrelated to amyloid beta and the drug works through a completely different, unknown mechanism.&rdquo;</span></span></span><br />
<br />
<span style='color: #4E565A'><span style='font-family: Arial, Helvetica, sans-serif'><span style='font-size: 12px;'>In the Pitt experiments, mice with the Alzheimer&rsquo;s gene mutations expressing human APOE3 or APOE4 were able to perform as well in cognitive tests as their non-Alzheimer&rsquo;s counterparts 10 days after beginning treatment with bexarotene. These tests included a spatial test using cues to find a hidden platform in a water maze and a long-term memory test of the mouse&rsquo;s ability to discriminate two familiar objects following introduction of a third, novel object.</span></span></span>]]></description>
		<pubDate>Fri, 24 May 2013 16:37:27 +0000</pubDate>
		<guid>http://www.longecity.org/forum/topic/63757-bexarotene-hes-here-to-help-again/</guid>
	</item>
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		<title><![CDATA[Cinnamaldehyde and Epicatechin, Cinnamon Compounds' Potential Ability to Prevent Alzheimer's]]></title>
		<link>http://www.longecity.org/forum/topic/63755-cinnamaldehyde-and-epicatechin-cinnamon-compounds-potential-ability-to-prevent-alzheimers/</link>
		<description><![CDATA[New study / Press release<br />
23 may 2013<br />
<br />
<a href='http://www.ia.ucsb.edu/pa/display.aspx?pkey=3022' class='bbc_url' title='External link' rel='nofollow external'>http://www.ia.ucsb.edu/pa/display.aspx?pkey=3022</a><br />
<a href='http://iospress.metapress.com/content/r570686k9m5431g0/?genre=article&id=doi%3a10.3233%2fJAD-122113' class='bbc_url' title='External link' rel='nofollow external'>http://iospress.metapress.com/content/r570686k9m5431g0/?genre=article&id=doi%3a10.3233%2fJAD-122113</a><br />
( <a href='http://brainupdates.com/2013/05/24/scientists-discover-cinnamon-compounds-potential-ability-to-prevent-alzheimers-cinnamaldehyde-and-epicatechin/' class='bbc_url' title='External link' rel='nofollow external'>http://brainupdates.com/2013/05/24/scientists-discover-cinnamon-compounds-potential-ability-to-prevent-alzheimers-cinnamaldehyde-and-epicatechin/</a> )<br />
<br />
<br />
Study Abstract reprint:<br />
<br />
<span style='color: #4A4A4A'><span style='font-family: Arial, 'Trebuchet MS', Verdana'><span style='font-size: 12px;'>Abnormal modifications in tau such as hyperphosphorylation, oxidation, and glycation interfere with its interaction with microtubules leading to its dissociation and self-aggregation into neurofibrillary tangles, a hallmark of Alzheimer's disease (AD). Previously we reported that an aqueous extract of cinnamon has the ability to inhibit tau aggregation in vitro and can even induce dissociation of tangles isolated from AD brain. In the present study, we carried out investigations with cinnamaldehyde (CA) and epicatechin (EC), two components of active cinnamon extract. We found that CA and the oxidized form of EC (EC</span></span></span><sub class='bbc'>ox</sub><span style='color: #4A4A4A'><span style='font-family: Arial, 'Trebuchet MS', Verdana'><span style='font-size: 12px;'>) inhibited tau aggregation in vitro and the activity was due to their interaction with the two cysteine residues in tau. Mass spectrometry of a synthetic peptide, SKCGS, representing the actual tau sequence, identified the thiol as reacting with CA and EC</span></span></span><sub class='bbc'>ox</sub><span style='color: #4A4A4A'><span style='font-family: Arial, 'Trebuchet MS', Verdana'><span style='font-size: 12px;'>. Use of a cysteine double mutant of tau showed the necessity of cysteine for aggregation inhibition by CA. The interaction of CA with tau cysteines was reversible and the presence of CA did not impair the biological function of tau in tubulin assembly in vitro. Further, these compounds protected tau from oxidation caused by the reactive oxygen species, H</span></span></span><sub class='bbc'>2</sub><span style='color: #4A4A4A'><span style='font-family: Arial, 'Trebuchet MS', Verdana'><span style='font-size: 12px;'>O</span></span></span><sub class='bbc'>2</sub><span style='color: #4A4A4A'><span style='font-family: Arial, 'Trebuchet MS', Verdana'><span style='font-size: 12px;'>, and prevented subsequent formation of high molecular weight species that are considered to stimulate tangle formation. Finally, we observed that EC can sequester highly reactive and toxic byproducts of oxidation such as acrolein. Our results suggest that small molecules that form a reversible interaction with cysteines have the potential to protect tau from abnormal modifications.</span></span></span>]]></description>
		<pubDate>Fri, 24 May 2013 15:19:37 +0000</pubDate>
		<guid>http://www.longecity.org/forum/topic/63755-cinnamaldehyde-and-epicatechin-cinnamon-compounds-potential-ability-to-prevent-alzheimers/</guid>
	</item>
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		<title>Seaweed?</title>
		<link>http://www.longecity.org/forum/topic/63754-seaweed/</link>
		<description><![CDATA[Found this article on Antioxidants in seaweed:<br />
<br />
<a href='http://www.howlifeworks.com/Article.aspx?Cat_URL=health_beauty&AG_URL=Rare_Undersea_Discovery_Could_Extend_Your_Life_by_10_20_or_30_Years_524&ag_id=1358&wid=F8AABABB-B41F-4A58-910F-E0224C2F42ED&did=2766&cid=1005&si_id=973' class='bbc_url' title='External link' rel='nofollow external'>http://www.howlifewo...=1005&si_id=973</a><br />
<br />
What do you think?]]></description>
		<pubDate>Fri, 24 May 2013 14:07:29 +0000</pubDate>
		<guid>http://www.longecity.org/forum/topic/63754-seaweed/</guid>
	</item>
	<item>
		<title>Using Zinc for Libido</title>
		<link>http://www.longecity.org/forum/topic/63751-using-zinc-for-libido/</link>
		<description><![CDATA[Hi all,<br />
<br />
After reading all the positive stories about how Zinc can be beneficial for libido, I have decided to try it myself. Went our and got Zinc Picolinate 22mg from Solgar.<br />
<br />
Questions<ul class='bbc'><li>What is the best form of zinc specifically for libido, does it even matter?<br /></li><li>The initial dose from yesterday gave me bad nausea, this morning I think I still feel the after effects. Does this go away with time or should I just use less? (I know 40mg is upper limit)<br /></li><li>Since zinc is not stored in the body can I just use it acutely pre sexy time?</li></ul>
<br />
Thanks!]]></description>
		<pubDate>Fri, 24 May 2013 11:46:59 +0000</pubDate>
		<guid>http://www.longecity.org/forum/topic/63751-using-zinc-for-libido/</guid>
	</item>
	<item>
		<title>Alternate MAOI ROAs and the effects</title>
		<link>http://www.longecity.org/forum/topic/63750-alternate-maoi-roas-and-the-effects/</link>
		<description><![CDATA[I'm wondering, when MAOIs (any of them, but particularly the ones like Parnate which are known for interactions) are taken sublingually or snorted, are the interactions altered?<br />
<br />
Since it bypasses the liver metabolism, wouldn't it not affect the liver's MAO levels, and thus not cause certain foods to be dangerous?<br />
<br />
Why doesn't this work? I assume it doesn't or else there would be no problem with MAOIs, and this would be the only method of taking MAOIs. I can't find anything on google about it at all.]]></description>
		<pubDate>Fri, 24 May 2013 09:01:02 +0000</pubDate>
		<guid>http://www.longecity.org/forum/topic/63750-alternate-maoi-roas-and-the-effects/</guid>
	</item>
	<item>
		<title>High ceruloplasmin = high ferritin, low serum iron?</title>
		<link>http://www.longecity.org/forum/topic/63749-high-ceruloplasmin-high-ferritin-low-serum-iron/</link>
		<description><![CDATA[Ceruloplasmin is involved in iron metabolism and it is important in iron transport, apparently high ceruloplasmin should at least reduce iron accumulation in organs (aceruloplasminemia causes accumulation of iron in organs) but I'm wondering where does that iron that is transported by ceruloplasmin goes? Does it go to ferritin stores? Is it used by the cells?<br />
Is there a link between ceruloplasmin levels and transferrin levels (which I think is the protein that regulates serum iron levels?)?<br />
<br />
I'm using a boron supplement, boron causes ceruloplasmin retention, I started having symptoms of low serum iron (myoclonus), I took an iron supplement and it seems to have provided some relief.<br />
My question is what should I do :<br />
- Since ceruloplasmin levels are higher, should I keep taking iron supplement with boron to compensate the needs? Will this cause a dangerous accumulation of iron (ferritin or whatever)?<br />
- Should I stop boron and wait for ceruloplasmin levels to normalize?<br />
- Should I keep taking boron and take citric acid? (citric acid is a ceruloplasmin inhibitor)<br />
- Or should I take both boron and iron supplement and counter high ferritin with phytic acid?]]></description>
		<pubDate>Fri, 24 May 2013 08:22:50 +0000</pubDate>
		<guid>http://www.longecity.org/forum/topic/63749-high-ceruloplasmin-high-ferritin-low-serum-iron/</guid>
	</item>
	<item>
		<title>Aniracetam.... very nice, first experience this gem.</title>
		<link>http://www.longecity.org/forum/topic/63746-aniracetam-very-nice-first-experience-this-gem/</link>
		<description><![CDATA[So far I've tried Pramiracetam, Piracetam, and now Aniracetam.<br />
<br />
Pramiracetam was my first and while it made me focused, it tasted like shit, was expensive, and kinda made me an emotionless robot. I gave it up due to the price, plus tolerance seemed to build after a few days and the effects did not last more than a few hours.<br />
<br />
Piracetam, taken with Fish Oil was my second, I tried it after reading all of Isochroma's posts on it. In high doses(30g with 30g fish oil) it gave me very enjoyable hypomania.... In low doses ~4g it gave me a nice moodlift, and no tolerance seemed to build, though I did not get that hyper mental enhancement some users report, my creativity was not increased, nor was my ability to recall things, or speak more creatively/fluidly.<br />
<br />
Aniracetam seems to be my savior, though I'm only on day 1 so I can't say for sure. I got 100g from HardRhino.com. I read that it was fat soluable and this definitely seems to be..... if anything it's hydrophobic because it can't dissolve in water for shit. Taste was not bad, very powdery substance, and seems to have much less of a taste than Piracetam.<br />
<br />
I took 4g this morning, with 2g fish oil... along with my usual stack(B-100, Sublingual B-12, Multi, 150mg Choline Bitartrate).... within minutes I was feeling great.<br />
<strong class='bbc'>Observed effects</strong>:<ul class='bbc'><li>I feel more fluid, and enhanced... even 5-6 hours later....much more significant and better than piracetam or prami, at any dosage.<br /></li><li>Focus enhanced similar to Pramiracetam, but none of the emotional blunting.<br /></li><li>Emotional uplifting present, but different from Piracetam... this feels more peaceful, there is definitely less stress present.<br /></li><li>Obvious anxiolytic effect in action.<br /></li><li>Tastes enhanced, and overall appetite, but in a controlled non-craving sort of way.<br /></li><li>More control....less stress MUCH easier to find the right words... no longer getting hung up searching for words when speaking. There is much less anti-anxiety.... while Piracetam and Prami reduced my anxiety via apathy.... Aniracetam feels to decrease anxiety by being more engaged in the moment, and handling it more smoothly.... definitely like this better in all aspects than Prami of Piracetam.<br /></li><li>I do not feel stimulated like I do when taking Piracetam... piracetam can prevent me from sleeping if I take it too late in the day... but I don't feel that on Aniracetam, though I do feel more alert.<br /></li><li>I can enjoy music and my environment much more... I feel more in-tune with the moment, and can vibe to music much easier... I find myself less concerned with what people think, but in an enjoyable happy way. Where as Pramiracetam or Piracetam made me not care what people think in an "I am powerful, fuck what you think" sort of way......<br /></li><li>I've found myself bobbing my head to music around random strangers....which I never do.<br /></li><li>I don't think twice about things that aren't worth thinking about.... where even on Piracetam or Pramiracetam, I would still have very very minor anxiety about certain meaningless things...Like for instance I would shutter at touching greasy foods with my hands because I like to keep my hands clean... but on Aniracetam, I just don't care really since things like that aren't that big of a deal... but that's just one example. It has positively effected many areas of my life when dealing with small things like this.</li></ul>
This stuff is excellent, and price isn't too bad.... at 4-5g per day averages around ~$2-3 bucks aday. I don't know how long I am going to take it... but I am eager to find out how the effects evolve over the next few weeks till my 100g runs out...This might entirely replace Piracetam in my prior stack, inspite of the price.]]></description>
		<pubDate>Fri, 24 May 2013 01:20:19 +0000</pubDate>
		<guid>http://www.longecity.org/forum/topic/63746-aniracetam-very-nice-first-experience-this-gem/</guid>
	</item>
	<item>
		<title>A Highly Reputable Book on Brain Aging Courtesy of the NCBI</title>
		<link>http://www.longecity.org/forum/topic/63745-a-highly-reputable-book-on-brain-aging-courtesy-of-the-ncbi/</link>
		<description><![CDATA[I am not sure if this is right way to go about disseminating information in Longecity, but there are actually three books I found while doing some research for school. All free from the NCBI: Brain Aging <a href='http://www.ncbi.nlm.nih.gov/books/NBK1834/' class='bbc_url' title='External link' rel='nofollow external'>http://www.ncbi.nlm.nih.gov/books/NBK1834/</a> , The Dynamic Synapse <a href='http://www.ncbi.nlm.nih.gov/books/NBK1843/' class='bbc_url' title='External link' rel='nofollow external'>http://www.ncbi.nlm.nih.gov/books/NBK1843/</a> , and Neuroplasticity and Memory <a href='http://www.ncbi.nlm.nih.gov/books/NBK1850/' class='bbc_url' title='External link' rel='nofollow external'>http://www.ncbi.nlm.nih.gov/books/NBK1850/</a> ; Hope these help somebody.]]></description>
		<pubDate>Fri, 24 May 2013 00:32:57 +0000</pubDate>
		<guid>http://www.longecity.org/forum/topic/63745-a-highly-reputable-book-on-brain-aging-courtesy-of-the-ncbi/</guid>
	</item>
	<item>
		<title>GABA + (Huperzine, Racetams, Bacopa, Lions Main)</title>
		<link>http://www.longecity.org/forum/topic/63744-gaba-huperzine-racetams-bacopa-lions-main/</link>
		<description><![CDATA[Hello everyone.<br />
<br />
I take 1500mgrs of GABA at bedtime, bcos I find it helps my back pain the next day.<br />
I also take 200mgrs of 7-Keto/day, and 1000mgrs of ALCAR on alternate days.<br />
Are there any adverse interactions with these amounts + any known nootropics like Huperzine A, Racetams, Bacopa, etc...<br />
<br />
Thanks.]]></description>
		<pubDate>Fri, 24 May 2013 00:19:09 +0000</pubDate>
		<guid>http://www.longecity.org/forum/topic/63744-gaba-huperzine-racetams-bacopa-lions-main/</guid>
	</item>
	<item>
		<title>The Deprenyl Diary  (with melatonin, piracetam, and choline)</title>
		<link>http://www.longecity.org/forum/topic/63741-the-deprenyl-diary-with-melatonin-piracetam-and-choline/</link>
		<description><![CDATA[5'7.5 Height,	158 lbs ,	21 years old<br />
<br />
Goal: Improve my motivation, focus, concentration, live longer, brain...<br />
 <br />
<p class='bbc_center'><span class='bbc_underline'>Daily Routine</span></p>
Deprenyl-&nbsp;&nbsp;5 to 10 mg a day **I know this is a higher than usual amount for my age**<em class='bbc'> <span style='color: #4b0082'>[all items in the brakets&nbsp;&nbsp;are related to Deprenyl]</span></em><br />
Piracetam - varies a lot, but usually around 1 gram a day<br />
Choline- less than 1gram, but my diet consist of eggs, 1/3-1/4 days a week I eat eggs.<br />
Melatonin- 5 mg usually<br />
<br />
<br />
<em class='bbc'><span class='bbc_underline'>Day 1</span>-</em> I notice no signs, besides being able to stay awake longer than usual.&nbsp;&nbsp;I also didn't mind walking as much. I did not take piracetam<br />
<span style='color: #4b0082'>(10 mg)</span><br />
<span class='bbc_underline'><em class='bbc'>Day 2</em>-</span> more energy, fears are lessen slightly, vivid/sexual dreams. Less than 1g of piracetam, but I don't measure it usually. 15 mg of melatonin, since I couldn't fall asleep with 5mg. <span style='color: #4b0082'>(15 mg)</span><br />
<span class='bbc_underline'><em class='bbc'>Day 3</em> -</span> I am not sure this is a placebo effect or not, but I had the energy/motivation to get over my fear of driving a bit. This is an intense fear of mine, since I am terrified of the police, and I don't think I am a good driver to begin with. I also bought things I usually would overly be paranoid about, but I need these items.&nbsp;&nbsp;I am also becoming more confident to ask people for help at a superstore, when usually I would just not speak up. Logical thinking has improve a bit, and I am thinking more from a financial/time point of view. <span style='color: #4b0082'>(7.5 mg as of now)</span><br />
<br />
Physically; I notice my veins are popping out a bit more than usual.<br />
<br />
<br />
---<br />
My grandma is also taking Deprenyl since I initially purchase it for her memory, and she told me she sees no signs with the pill yet. She cannot handle piracetam/choline, since it taste gross to her. She is taking 5 mg of Deprenyl a day, this would be day 3 for her as well.]]></description>
		<pubDate>Thu, 23 May 2013 22:30:20 +0000</pubDate>
		<guid>http://www.longecity.org/forum/topic/63741-the-deprenyl-diary-with-melatonin-piracetam-and-choline/</guid>
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		<title>lofepramine method of action?</title>
		<link>http://www.longecity.org/forum/topic/63740-lofepramine-method-of-action/</link>
		<description><![CDATA[Does anyone know the receptors lofepramine acts on? The more information the better. I assume SNRI & anticholinergic effects as its a TCA. However I'd be interested to know about any binding studies and more improtantly there results.<br />
<br />
This drug was suggested incombo with Agomelatine after two other more common drugs I've yet to trial (venlafaxine and buriprion). It was suggested over the older TCA's due to decreased risk in regards to suicide/self injury.]]></description>
		<pubDate>Thu, 23 May 2013 22:21:18 +0000</pubDate>
		<guid>http://www.longecity.org/forum/topic/63740-lofepramine-method-of-action/</guid>
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	<item>
		<title>What ever happened to epithalon?</title>
		<link>http://www.longecity.org/forum/topic/63739-what-ever-happened-to-epithalon/</link>
		<description><![CDATA[About 10 years ago, about 5 papers came out of Russia on epithalon. For example:<br />
<br />
<em class='bbc'>Bull Exp Biol Med.</em> 2003 Jun;135(6):590-2.<br />
<strong class='bbc'>Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells.</strong><br />
Khavinson VKh, Bondarev IE, Butyugov AA.<br />
St. Petersburg Institute of Bioregulation and Gerontology, North-Western Division of Russian Academy of Medical Sciences.<br />
ibg@medport.ru<br />
PMID: 12937682<br />
<a href='http://morelife.org/references/pmid_12000000+.html' class='bbc_url' title='External link' rel='nofollow external'>http://morelife.org/references/pmid_12000000+.html</a><br />
<br />
I&nbsp;&nbsp;haven't been able to find anything about it since then. I can't find a single study where it was given to humans, or a double blind study to measure the effects of epithalon on telomere length. Does anyone know what happened?]]></description>
		<pubDate>Thu, 23 May 2013 19:50:22 +0000</pubDate>
		<guid>http://www.longecity.org/forum/topic/63739-what-ever-happened-to-epithalon/</guid>
	</item>
	<item>
		<title>Singularity Music Video</title>
		<link>http://www.longecity.org/forum/topic/63738-singularity-music-video/</link>
		<description><![CDATA[Not entirely sure this is the best representation of Kurzweil's Singularity, but it's techno and flashy.<br />
<br />
<a href='http://www.youtube.com/watch?feature=player_embedded&v=F0QSSc3Mn9c#!' class='bbc_url' title='External link' rel='nofollow external'>http://www.youtube.c...v=F0QSSc3Mn9c#!</a>]]></description>
		<pubDate>Thu, 23 May 2013 17:16:44 +0000</pubDate>
		<guid>http://www.longecity.org/forum/topic/63738-singularity-music-video/</guid>
	</item>
	<item>
		<title>Sunifiram side effects thread</title>
		<link>http://www.longecity.org/forum/topic/63734-sunifiram-side-effects-thread/</link>
		<description><![CDATA[Since sunifiram has not yet undergone human trials, as far as I know, it would be a good idea for those of us taking it to list any side effects, whether beneficial or adverse. Of course it is hard to determine what a <strong class='bbc'>side</strong> effect is when a drug does not have an official "on-label" effect, but we shall assume that the intended effect is cognitive enhancement. This thread should be used for listing any effects that either do not relate to cognitive enhancement, or have a perceived adverse relationship to cognitive enhancement.<br />
<br />
Personally I have only been using sunifiram for a few days (two microscoops per day, one in morning, one in afternoon), with a small amount of a choline source (centrophenoxine) taken at a different time during the day (with lunch). I am not taking any racetam during my trial of sunifiram. So far I have noticed the following side effects:<br />
<br />
&nbsp;&nbsp;- like pramiracetam, sunifiram noticeably <strong class='bbc'>dampens</strong> the slight, very high-pitched tinnitus that is aggravated in me by piracetam, aniracetam, oxiracetam and noopept&nbsp;&nbsp;<br />
<br />
- about 30 minutes to an hour after taking sunifiram, I notice twitching in the muscles around my eyes, sometimes heaviness of eyelids. This subsides after a further 30 minutes (approx.)<br />
<br />
- so far I have woken up with a mild headache and stuffiness, especially in my ears, the morning after taking sunifiram; I also seem to need more sleep. I am aware that others have reported that they need less sleep with sunifiram. I shall monitor this and report back if this perceived side effect proves to have been unrelated to sunifiram.]]></description>
		<pubDate>Thu, 23 May 2013 11:40:45 +0000</pubDate>
		<guid>http://www.longecity.org/forum/topic/63734-sunifiram-side-effects-thread/</guid>
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		<title>Fluoxetine (Prozac) increases hippocampal BDNF levels and neurogenesis</title>
		<link>http://www.longecity.org/forum/topic/63733-fluoxetine-prozac-increases-hippocampal-bdnf-levels-and-neurogenesis/</link>
		<description><![CDATA[<span style='color: #333333'><span style='font-family: Helvetica, Arial, serif'><span style='font-size: 12px;'><br />
<em class='bbc'>A benzodiazepine impairs the neurogenic and behavioural effects of fluoxetine in a rodent model of chronic stress</em>, Abstract (OD: apr.29.2013):<em class='bbc'> </em>&ldquo;<strong class='bbc'>Antidepressant agents such as fluoxetine have been shown to produce neurogenic effects involving transcriptional and translational changes that direct molecular and cellular plasticity</strong>. These cellular and molecular events appear necessary to mediate the therapeutic effects of fluoxetine and may be generated through the ability for fluoxetine to regulate BDNF levels. Clinically, benzodiazepines are frequently used in combination with standard antidepressants both for initial treatment and maintenance therapy, especially when comorbid anxiety is present. However, very little is known regarding the consequence of combined treatment of benzodiazepines and antidepressant on the development of clinical effect. The current study therefore examined<strong class='bbc'> the effect of co-administration of fluoxetine and the benzodiazepine, diazepam</strong>, on hippocampal neurogenesis in the social isolation rodent model of chronic stress. We demonstrate that <strong class='bbc'>9 weeks of social isolation induces a deficit in motivational behaviour with increased anxiety as well as impairment in hippocampal neurogenesis</strong>. This was parallelled by <strong class='bbc'>reduced BDNF levels in the hippocampus</strong>. While treatment with fluoxetine alone for 3 weeks restored anxiety behaviour as well as progenitor cell proliferation and the generation of new hippocampal neurons, this effect was prevented by co-administration with diazepam. This suggests that<strong class='bbc'> co-administering benzodiazepines with antidepressants could significantly delay or prevent the cellular and behavioural improvement needed by patients</strong>. These findings indicate the need for future clinical studies designed to investigate the combined effects of benzodiazepines and antidepressants in patients.&rdquo;</span></span></span><span style='color: #333333'><span style='font-family: Helvetica, Arial, serif'><span style='font-size: 12px;'><br />
Highlights:<br />
Treatment with fluoxetine or diazepam reduces anxiety/depressive-like behaviour.<br />
<strong class='bbc'>Treatment with fluoxetine alone restores hippocampal neurogenesis.</strong><br />
<strong class='bbc'>Treatment with fluoxetine alone increased hippocampal BDNF levels.</strong><br />
<strong class='bbc'>Positive effects of fluoxetine are prevented by co-administration with diazepam.</strong></span></span></span><span style='color: #333333'><span style='font-family: Helvetica, Arial, serif'><span style='font-size: 12px;'><br />
<a href='http://brainupdates.com/2013/05/23/fluoxetine-prozac-increases-hippocampal-bdnf-levels-and-neurogenesis/' class='bbc_url' title='External link' rel='nofollow external'>http://brainupdates.com/2013/05/23/fluoxetine-prozac-increases-hippocampal-bdnf-levels-and-neurogenesis/</a></span></span></span>]]></description>
		<pubDate>Thu, 23 May 2013 08:31:01 +0000</pubDate>
		<guid>http://www.longecity.org/forum/topic/63733-fluoxetine-prozac-increases-hippocampal-bdnf-levels-and-neurogenesis/</guid>
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	<item>
		<title>Slowing the aging proecess..with antibiotics??</title>
		<link>http://www.longecity.org/forum/topic/63732-slowing-the-aging-proecesswith-antibiotics/</link>
		<description><![CDATA[In short, the article suggests that it might be possible to extend life in humans by acitivating the same pathway that scientists acitivated in roundworms(that sounds plausible), and by using the same means, antibiotics(IMO very questionable).<br />
<br />
<a href='http://www.sciencedaily.com/releases/2013/05/130522131120.htm' class='bbc_url' title='External link' rel='nofollow external'>http://www.sciencedaily.com/releases/2013/05/130522131120.htm</a>]]></description>
		<pubDate>Thu, 23 May 2013 05:55:15 +0000</pubDate>
		<guid>http://www.longecity.org/forum/topic/63732-slowing-the-aging-proecesswith-antibiotics/</guid>
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		<title>Iron Bisglycinate improves my anhedonia but is it safe</title>
		<link>http://www.longecity.org/forum/topic/63731-iron-bisglycinate-improves-my-anhedonia-but-is-it-safe/</link>
		<description><![CDATA[I recently had my ferritin levels checked and they came back at 36 ug/L on a reference range of 22 - 322. Iron is a co-factor in the production of dopamine by working alongside tyrosine hydroxylase. From the articles I've read, RLS develops when ferritin levels drop below 50 ug/L. I've actually been having some RLS symptoms before I started supplementing with Iron, but nothing too severe. I actually do not have any RLS now and I think it's because of the iron. Also, my hemoglobin came back low.<br />
<br />
I started taking 18 mg of Iron Bisglycinate 2 weeks ago. The brand name is NOW Foods. I take it with my multivitamin, which has Vitamin C, and with magnesium citrate. This article states that iron in combination with vitamin c promotes free radicals:<br />
<br />
<div style='background:beige;border-style:dotted; border-width:3px; ;border-color:grey;padding:5px; width: 88%;'>
<div style='color:black;'>Co-supplementation of ferrous salts with vitamin C exacerbates oxidative stress in the gastrointestinal tract leading to ulceration in healthy individuals, exacerbation of chronic gastrointestinal inflammatory diseases and can lead to cancer. Reactive oxygen and nitrogen species (RONS) have been ascribed an important role in oxidative stress. Redox-active metal ions such as Fe(II) and Cu(I) further activate RONS and thus perpetuate their damaging effects. Ascorbic acid can exert a pro-oxidant effect by its interaction with metal ions via a number of established RONS generating systems which are reviewed here. Further studies are required to examine the detrimental effects of nutraceuticals especially in chronic inflammatory conditions which co-present with anaemia.<br><br></div>
<a href='http://www.ncbi.nlm.nih.gov/pmc/articles/PMC340385/'><b>&#8594; source (external link)</b></a></div>
<br />
<br />
The benefits I've noticed from Iron supplementation are as follows:<br />
<ul class='bbc'><li>Slightly improved consummatory and anticipatory anhedonia<br /></li><li>Slightly improved libido<br /></li><li>Laughter is actually enjoyable now whereas before it was just a way for me to blow air through my nose<br /></li><li>Improved verbal fluency. What I mean by this is that I am better able to articulate myself and get my message across. I also am able to better form sentences as well as utilize terms that accurately describe what I am conjuring in my head.<br /></li><li>Less shortness of breath and improved recovery when doing HIIT exercise</li></ul>
Should I just take it every other day to make the effective dose 9 mg instead of 18 mg? Would that be safe in the long term?]]></description>
		<pubDate>Thu, 23 May 2013 05:29:28 +0000</pubDate>
		<guid>http://www.longecity.org/forum/topic/63731-iron-bisglycinate-improves-my-anhedonia-but-is-it-safe/</guid>
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	<item>
		<title>Hi everyone, newbie</title>
		<link>http://www.longecity.org/forum/topic/63730-hi-everyone-newbie/</link>
		<description><![CDATA[Just wanted to introduce myself. I'm 35yrs old and decided to join the community just so I can give my reviews on nootropics as I experiment with them. Newest one I'm playing round with is sunifaram. I've used all sorts of nutritional supps and noops and am a fan. I'm also starting internal med residency in philly in bout a week. Since I'll be crazy crunched on time with 80 hour weeks noops may become a necessity. peace]]></description>
		<pubDate>Thu, 23 May 2013 02:53:50 +0000</pubDate>
		<guid>http://www.longecity.org/forum/topic/63730-hi-everyone-newbie/</guid>
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	<item>
		<title>Common Food Supplement Phosphatidylserine Fights Degenerative Brain Disorders</title>
		<link>http://www.longecity.org/forum/topic/63727-common-food-supplement-phosphatidylserine-fights-degenerative-brain-disorders/</link>
		<description><![CDATA[NEW PRESS RELEASE<br />
<br />
<a href='http://www.aftau.org/site/News2?page=NewsArticle&id=18589' class='bbc_url' title='External link' rel='nofollow external'>http://www.aftau.org/site/News2?page=NewsArticle&id=18589</a><br />
<a href='http://hmg.oxfordjournals.org/content/early/2013/03/29/hmg.ddt126' class='bbc_url' title='External link' rel='nofollow external'>http://hmg.oxfordjournals.org/content/early/2013/03/29/hmg.ddt126</a><br />
( <a href='http://brainupdates.com/2013/05/22/common-food-supplement-phosphatidylserine-fights-degenerative-brain-disorders/' class='bbc_url' title='External link' rel='nofollow external'>http://brainupdates.com/2013/05/22/common-food-supplement-phosphatidylserine-fights-degenerative-brain-disorders/</a> )<br />
<br />
<br />
COPY:<br />
<span style='color: #333333'><span style='font-family: Helvetica, Arial, serif'><span style='font-size: 12px;'><br />
Nutritional supplement delays advancement of Parkinson&rsquo;s and Familial Dysautonomia, TAU researchers discover.</span></span></span><span style='color: #333333'><span style='font-family: Helvetica, Arial, serif'><span style='font-size: 12px;'><br />
Widely available in pharmacies and health stores,<strong class='bbc'>phosphatidylserine is a natural food supplement produced from beef, oysters, and soy. Proven to improve cognition and slow memory loss, it&rsquo;s a popular treatment for older people experiencing memory impairment</strong>. Now a team headed by <strong class='bbc'><em class='bbc'>Prof. Gil Ast</em></strong> and <strong class='bbc'><em class='bbc'>Dr. Ron Bochner</em></strong> of <strong class='bbc'><em class='bbc'>Tel Aviv University</em></strong>&lsquo;s <strong class='bbc'><em class='bbc'>Department of Human Molecular Genetics</em></strong> has discovered that <strong class='bbc'>the same supplement improves the functioning of genes involved in degenerative brain disorders, including Parkinson&rsquo;s disease and Familial Dysautonomia (FD)</strong>.</span></span></span><br />
<br />
In FD, a rare genetic disorder that impacts the nervous system and appears almost exclusively in the Ashkenazi Jewish population, a genetic mutation prevents the brain from manufacturing healthy IKAP proteins &mdash; which likely have a hand in cell migration and aiding connections between nerves &mdash; leading to the early degeneration of neurons. When the supplement was applied to cells taken from FD patients, the gene function improved and an elevation in the level of IKAP protein was observed, reports Prof. Ast. These results were replicated in a second experiment which involved administering the supplement orally to mouse populations with FD.<br />
The findings, which have been published in the journal <em class='bbc'>Human Molecular Genetics</em>, are very encouraging, says Prof. Ast.<p class='bbc_indent' style='margin-left: 40px;'><br />
&ldquo;That we see such an effect on the brain &mdash; the most important organ in relation to this disease &mdash; shows that the supplement can pass through the blood-brain barrier even when administered orally, and accumulate in sufficient amounts in the brain.&rdquo;</p>
<p class='bbc_center'><strong class='bbc'>Slowing the death of nerve cells</strong></p>
Already approved for use as a supplement by the FDA, phosphatidylserine contains a molecule essential for transmitting signals between nerve cells in the brain. Prof. Ast and his fellow researchers decided to test whether the same chemical, which is naturally synthesized in the body and known to boost memory capability, could impact the genetic mutation which leads to FD.<br />
Researchers applied a supplement derived from oysters, provided by the Israeli company Enzymotec, to cells collected from FD patients. Noticing a robust effect on the gene, including a jump in the production of healthy IKAP proteins, they then tested the same supplement on mouse models of FD, engineered with the same genetic mutation that causes the disease in humans.<br />
The mice received the supplement orally, every two days for a period of three months. Researchers then conducted extensive genetic testing to assess the results of the treatment.<p class='bbc_indent' style='margin-left: 40px;'><br />
&ldquo;We found a significant increase of the protein in all the tissues of the body,&rdquo; reports Prof. Ast, including an eight-fold increase in the liver and 1.5-fold increase in the brain. &ldquo;While the food supplement does not manufacture new nerve cells, it probably delays the death of existing ones,&rdquo; he adds.</p>
<p class='bbc_center'><strong class='bbc'>Therapeutic potential for Parkinson&rsquo;s</strong></p>
That <strong class='bbc'>the supplement is able to improve conditions in the brain, even when given orally</strong>, is a significant finding, notes Prof. Ast. Most medications enter the body through the blood stream, but are incapable of breaking through the barrier between the blood and the brain.<br />
In addition, the researchers say the supplement&rsquo;s positive effects extend beyond the production of IKAP. Not only did phosphatidylserine impact the gene associated with FD, but it also altered the level of a total of 2400 other genes &mdash; hundreds of which have been connected to Parkinson&rsquo;s disease in previous studies.<br />
The researchers believe that the supplement may have a beneficial impact on a number of degenerative diseases of the brain, concludes Prof. Ast, including a major potential for the development of new medications which would help tens of millions of people worldwide suffering from these devastating diseases.]]></description>
		<pubDate>Wed, 22 May 2013 23:15:09 +0000</pubDate>
		<guid>http://www.longecity.org/forum/topic/63727-common-food-supplement-phosphatidylserine-fights-degenerative-brain-disorders/</guid>
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		<title>Reducing caloric intake or activating SIRT1 delays nerve cell loss</title>
		<link>http://www.longecity.org/forum/topic/63726-reducing-caloric-intake-or-activating-sirt1-delays-nerve-cell-loss/</link>
		<description><![CDATA[<span style='color: #333333'><span style='font-family: Helvetica, Arial, serif'><span style='font-size: 12px;'>NEW PRESS RELEASE</span></span></span><br />
<span style='color: #333333'><span style='font-family: Helvetica, Arial, serif'><span style='font-size: 12px;'><a href='http://www.eurekalert.org/pub_releases/2013-05/sfn-rci051313.php' class='bbc_url' title='External link' rel='nofollow external'>http://www.eurekaler...n-rci051313.php</a></span></span></span><br />
<span style='color: #333333'><span style='font-family: Helvetica, Arial, serif'><span style='font-size: 12px;'><a href='http://www.jneurosci.org/content/33/21/8951.abstract' class='bbc_url' title='External link' rel='nofollow external'>http://www.jneurosci...1/8951.abstract</a></span></span></span><br />
<span style='color: #333333'><span style='font-family: Helvetica, Arial, serif'><span style='font-size: 12px;'>( <a href='http://brainupdates.com/2013/05/22/reducing-caloric-intake-or-activating-sirt1-delays-nerve-cell-loss/' class='bbc_url' title='External link' rel='nofollow external'>http://brainupdates....erve-cell-loss/</a> )</span></span></span><br />
<br />
<span style='color: #333333'><span style='font-family: Helvetica, Arial, serif'><span style='font-size: 12px;'>COPY:</span></span></span><br />
<span style='color: #333333'><span style='font-family: Helvetica, Arial, serif'><span style='font-size: 12px;'>Animal study points to role of protein in anti-aging benefits of calorie restriction.</span></span></span><br />
<span style='color: #333333'><span style='font-family: Helvetica, Arial, serif'><span style='font-size: 12px;'><strong class='bbc'>Activating an enzyme known to play a role in the anti-aging benefits of calorie restriction delays the loss of brain cells and preserves cognitive function in mice</strong>, according to a study published in the May 22 issue of <em class='bbc'>The Journal of Neuroscience</em>. The findings could one day guide researchers to discover drug alternatives that slow the progress of age-associated impairments in the brain.</span></span></span><br />
<br />
Previous studies have shown that reducing calorie consumption extends the lifespan of a variety of species and decreases the brain changes that often accompany aging and neurodegenerative diseases such as Alzheimer&rsquo;s. <strong class='bbc'>There is also evidence that caloric restriction activates an enzyme called Sirtuin 1 (SIRT1)</strong>, which studies suggest offers some protection against age-associated impairments in the brain.<br />
In the current study, Li-Huei Tsai, PhD, Johannes Gr&auml;ff, PhD, and others at the Picower Institute For Learning and Memory, Massachusetts Institute of Technology, and Howard Hughes Medical Institute, tested whether reducing caloric intake would delay the onset of nerve cell loss that is common in neurodegenerative disease, and if so, <strong class='bbc'>whether SIRT1 activation was driving this effect</strong>. The group not only confirmed that caloric restriction delays nerve cell loss, but also found that a <strong class='bbc'>drug that activates SIRT1 produces the same effects</strong>.<br />
<p class='bbc_indent' style='margin-left: 40px;'><br />
&ldquo;There has been great interest in finding compounds that mimic the benefits of caloric restriction that could be used to delay the onset of age-associated problems and/or diseases,&rdquo; said Luigi Puglielli, MD, PhD, who studies aging at the University of Wisconsin, Madison, and was not involved in this study. &ldquo;If proven safe for humans, this study suggests <strong class='bbc'>such a drug could be used as a preventive tool to delay the onset of neurodegeneration associated with several diseases that affect the aging brain</strong>,&rdquo; Puglielli added.</p>
In the study, Tsai&rsquo;s team first decreased by 30 percent the normal diets of mice genetically engineered to rapidly undergo changes in the brain associated with neurodegeneration. Following three months on the diet, the mice completed several learning and memory tests.<br />
<p class='bbc_indent' style='margin-left: 40px;'><br />
&ldquo;<strong class='bbc'>We not only observed a delay in the onset of neurodegeneration in the calorie-restricted mice, but the animals were spared the learning and memory deficits of mice that did not consume reduced-calorie diets</strong>,&rdquo; Tsai explained.</p>
Curious if they could recreate the benefits of caloric restriction without changing the animals&rsquo; diets, the scientists gave a separate group of mice a drug that activates SIRT1. Similar to what the researchers found in the mice exposed to reduced-calorie diets, the mice that received the drug had less cell loss and better cellular connectivity than the mice that did not receive the drug. Additionally, the mice that received the drug treatment performed as well as normal mice in learning and memory tests.<br />
<p class='bbc_indent' style='margin-left: 40px;'><br />
&ldquo;The question now is whether this type of treatment will work in other animal models, whether it&rsquo;s safe for use over time, and whether it only temporarily slows down the progression of neurodegeneration or stops it altogether,&rdquo; Tsai said.</p>]]></description>
		<pubDate>Wed, 22 May 2013 23:13:25 +0000</pubDate>
		<guid>http://www.longecity.org/forum/topic/63726-reducing-caloric-intake-or-activating-sirt1-delays-nerve-cell-loss/</guid>
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	<item>
		<title>SSRI long term damage/risk thread</title>
		<link>http://www.longecity.org/forum/topic/63722-ssri-long-term-damagerisk-thread/</link>
		<description><![CDATA[Considering that I will be at a psychiatrist in a few hours, complaining about social anxiety and attention problems, there is a moderate chance that I will be given an SSRI.<br />
<br />
So, this thread is for assessing the risk of taking an SSRI, mostly in terms of long term risk (post cessation).<br />
<br />
There are often claims of long term effects of SSRIs unsupported by research.<br />
<br />
The goal of this thread is to assess the risks based on scientific evidence and scientific reasoning as well as talk about preventative measures.<br />
<br />
Short term effects (ie: those while on the SSRI that diminish after quitting) are not as important, as you can obviously stop the medicine if you find them to be unbearable.<br />
<br />
My main areas of interest are SSRIs with respect to (long term)<ul class='bbc'><li>motivation<br /></li><li>emotion/affect blunting<br /></li><li>libido<br /></li><li>concentration/focus<br /></li><li>memory<br /></li><li>pleasure<br /></li><li>"Brain Zaps"<br /></li><li>effects in the ADHD population<br /></li><li>effects in the Personality Disordered population (specifically avoidant and schizoid)</li></ul>
<br />
If you have another concern, please bring it up.<br />
<br />
Anecdotes are welcome but will not be considered evidence.]]></description>
		<pubDate>Wed, 22 May 2013 16:30:00 +0000</pubDate>
		<guid>http://www.longecity.org/forum/topic/63722-ssri-long-term-damagerisk-thread/</guid>
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		<title>Experimentation process</title>
		<link>http://www.longecity.org/forum/topic/63716-experimentation-process/</link>
		<description><![CDATA[This thread is to gather together some responses about how different people go about trying new substances (nootropics), routines, habits, or whatever else (could be anything, exercise, sleep patterns, or even tdcs for example). I'll focus on and talk about substances but any response is welcome and in general I mean any of these things.<br />
<br />
I have always wondered how people decide what does and doesn't have an effect on them, and how much effect if any. One of the iffy things about nootropics is that results are subjective, sometimes hard to discern, often environmentally affected or dependent (substanceX is better when doing a specific type of task, you didn't get enough sleep that night, you had a bad day), and can even vary wildly.<br />
<br />
<strong class='bbc'>Some example questions might be:</strong><br />
<br />
1. Do you "purge" or abstain from other substances for a time before trying a new one as to isolate the feelings/results?<br />
<br />
2. Do you have a general list of substances that works for you that you always take and just add one at a time?<br />
<br />
3. Do you combine new substances if they are known to have synergy or try them separate? Or both?<br />
<br />
4. How do you isolate "problem" substances? How do you figure out which ones are making you feel bad or sub-par? (for example you could add a new substance and it interacts badly with something else you are taking but gives great results otherwise)<br />
<br />
5. If you do abstain from all substances to try new ones, do you add one back in at a time?<br />
<br />
6. How do you measure results? (Sometimes your Lumosity/dnb/whatever scores might be exactly the same but you feel like crap, or the other way around.) Do you keep long term averages/records?<br />
<br />
7. How do you determine dosage? Do you try varying doses on both sides of the norm?<br />
<br />
8. Do you do all of these things enough times to where you can actually measure it?<br />
<br />
In summary, how careful and precise are you when trying new things? Ideally we would be conducting blind experiments on ourselves (placebo/dosage level), abstain beforehand, add in substances (also blind) one at a time, and micromanage the hell out of it to determine what is and isn't worth it. But who does all that?<br />
________________________________________________________________________<br />
<br />
<br />
<br />
<br />
Feel free to skip the rest of this post and answer, it gets a little off topic. Below are some of my personal opinions/experiences and general answers to the above questions. <br />
<br />
I'm sure everyone has a different story, but when I started taking nootropics I just bought a bunch of them and was too excited to wait. I spend $100-200 buying everything I wanted to try after extensive research just to see what worked and often took too many things together, then spent some more money every couple months searching for stuff that worked. Daily environmental variables ...varied. Sometimes I took them when working/studying hard, sometimes I took them and ended up going to the bar with friends. Sometimes they synergized, other times they gave me brain fog and made me tired. One day a combo would have great effects, the next it had nothing, the next it made me feel like crap. .... I could go on.<br />
<br />
I tried keeping a log at one point when I started CILTEP, but it faded over time (with the effects of CILTEP). I've also tried "purging" and many of the other techniques above but when I think back it seems more like a jumble of "oh this works!"...(3 days later)..."I don't really notice anything." I think I got the greatest effects from CILTEP, but I don't notice anything anymore (about 2 months later) and stopped buying supplies for it.<br />
<br />
Just to mention: I am one of those people that can drink until I throw up and still be pretty close to sober, my body rejects it and my mind stays sober. I need double doses of ibuprofen/acetaminophen/etc to have an effect. Marijuana doesn't affect me (have tried a handful of times). I need more / stronger / higher potency for most mind/body altering substances to have a normal effect.<br />
<br />
The only things that I feel are worth it to take at this point are: Modafinil, phenylpiracetam, and noopept/sunifram have about the same effect on me (little). I wish I could pinpoint some of the more subtle positive effects from the rest of the bottles sitting on my shelves, which is one reason I made this thread. The forum also seems to be lacking this topic, people say "try it out" but don't really describe how.<br />
<br />
I'm sure there are people on here that micromanage their regimen, others that buy in bulk and swallow in bulk, and many who do something in between. What about you? Do you have advice for me and anyone else that stumbles upon this in the future?]]></description>
		<pubDate>Wed, 22 May 2013 12:02:48 +0000</pubDate>
		<guid>http://www.longecity.org/forum/topic/63716-experimentation-process/</guid>
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		<title>Confusion on Himalaya Brand Bacopa Dosage</title>
		<link>http://www.longecity.org/forum/topic/63715-confusion-on-himalaya-brand-bacopa-dosage/</link>
		<description><![CDATA[I'm going to try out Bacopa and want to be sure I take doses that match what studies have shown. I've seen that most studies show you need 300mg ..standardized to 55-percent combined bacosides A and B, this has all that, the label :<br />
LINK: <a href='http://www.vitaminshoppe.com/store/en/browse/sku_detail.jsp?id=H0-1006#.UZxY8bXvt1E' class='bbc_url' title='External link' rel='nofollow external'>http://www.vitaminshoppe.com/store/en/browse/sku_detail.jsp?id=H0-1006#.UZxY8bXvt1E</a><br />
<br />
<br />
										<br />
<span style='font-size: 8px;'>Amount Per<br />
				Serving</span>										<br />
<span style='font-size: 8px;'>% Daily<br />
				Value</span>														<span rel='lightbox'><img src='http://www.vitaminshoppe.com/images/en/global/block.gif' alt='Posted Image' class='bbc_img' /></span>											<br />
<span style='font-size: 8px;'>ORGANIC BACOPA WHOLE PLANT (BACOPA MONNIERI PENNELL)(STANDARDIZED EXTRACT)</span>										<br />
<span style='font-size: 10px;'>100 Mg</span>										<br />
<span style='font-size: 10px;'>N/A*</span>														<span rel='lightbox'><img src='http://www.vitaminshoppe.com/images/en/global/block.gif' alt='Posted Image' class='bbc_img' /></span>											<br />
<span style='font-size: 8px;'>ORGANIC BACOPA WHOLE PLANT (60% BACOPA SAPONINS CONTAINING BACOSIDE A&B)</span>										<br />
<span style='font-size: 10px;'>60 Mg</span>										<br />
<span style='font-size: 10px;'>N/A*</span>														<span rel='lightbox'><img src='http://www.vitaminshoppe.com/images/en/global/block.gif' alt='Posted Image' class='bbc_img' /></span>											<br />
<span style='font-size: 8px;'>ORGANIC BACOPA WHOLE PLANT (1% BACOPA SAPONINS CONTAINING BACOSIDE A&B - 6.5MG)</span>										<br />
<span style='font-size: 10px;'>650 Mg</span>										<br />
<span style='font-size: 10px;'>N/A*</span>						<br />
<br />
So in order to match the studies do I need to take at least three of these a day? It's the extract that matters right, not the 650mg whole plant..yes? I've done searches on the forums but people are mainly discussing just MG and don't specify if it has to be extract or not. Thanks!]]></description>
		<pubDate>Wed, 22 May 2013 05:39:11 +0000</pubDate>
		<guid>http://www.longecity.org/forum/topic/63715-confusion-on-himalaya-brand-bacopa-dosage/</guid>
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		<title>Slow motion perception. Increasing information processing.</title>
		<link>http://www.longecity.org/forum/topic/63714-slow-motion-perception-increasing-information-processing/</link>
		<description><![CDATA[I'm looking at other ways to maximize my potential. I'm wondering if it's possible to slow down time for longer periods. For example if you're in a car accident or a life threating situation your body reacts with speeding up your information processing speed through complex mechanisms. This in turn gives rise to a subjective perception of time flowing slower.<br />
<br />
From wikipedia:<br />
<p class='citation'>Quote</p><div class="blockquote"><div class='quote'>
According to Steve Taylor, who teaches courses on personal development at the University of Manchester, clock time may be about minutes and hours but Real Time is down to how we experience it and it differs from person to person. For instance, during high-stress situations, such as an accident, the brain receives massive amounts of data to process which alters the brain's perception of time. This is believed to be an evolutionary mechanism adapted by the brain to increase human survival rates. Therefore, during an accident a person can react quickly and make a decision in a short period of time.[citation needed] A recent research model proposes that the perception of space and time undergoes strong distortions during rapid saccadic eye movements.[3] The expectation of perceived motion is necessary for anticipatory slow eye movements. [4]</div></div>
<br />
Does anyone have any idea how to extend the period of time you can experience. <br />
<br />
I'm thinking histamine might have a strong effect on the perception of time.]]></description>
		<pubDate>Wed, 22 May 2013 05:28:26 +0000</pubDate>
		<guid>http://www.longecity.org/forum/topic/63714-slow-motion-perception-increasing-information-processing/</guid>
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		<title><![CDATA[Does the length of a fatty acid affect whether or not it's healthy?]]></title>
		<link>http://www.longecity.org/forum/topic/63712-does-the-length-of-a-fatty-acid-affect-whether-or-not-its-healthy/</link>
		<description><![CDATA[E,g, are longer saturated fatty acids better than shorter ones?<br />
<br />
What about longer mono/poly-unsaturated fatty acids?]]></description>
		<pubDate>Wed, 22 May 2013 03:14:09 +0000</pubDate>
		<guid>http://www.longecity.org/forum/topic/63712-does-the-length-of-a-fatty-acid-affect-whether-or-not-its-healthy/</guid>
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		<title>Optimal Dosage for Stimulants (Adderall, Ritalin, Vyvanse, etc)</title>
		<link>http://www.longecity.org/forum/topic/63710-optimal-dosage-for-stimulants-adderall-ritalin-vyvanse-etc/</link>
		<description><![CDATA[I've noticed that lots of people on here and other forums take very high dosages of stimulants (for example, 30 mg or more of IR Adderall). Are these people really on the optimal dosage, or are they measuring efficacy by the "high" feelings that they experience?<br />
<br />
I've always taken 15-20mg of IR adderall with mixed results, but I'm wondering if I should experiment with higher or lower dosages. Does playing around with the dosage make tolerance more likely? Why is it that many psychiatrists believe tolerance to be a non-issue when it comes to stimulants?]]></description>
		<pubDate>Wed, 22 May 2013 00:16:23 +0000</pubDate>
		<guid>http://www.longecity.org/forum/topic/63710-optimal-dosage-for-stimulants-adderall-ritalin-vyvanse-etc/</guid>
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		<title>Diatomaceous Earth and Clay with Greens</title>
		<link>http://www.longecity.org/forum/topic/63709-diatomaceous-earth-and-clay-with-greens/</link>
		<description><![CDATA[I have heard that clay and diatomaceous earth only remove negatively charged ions meaning that it would not absorb any beneficial nutrients, just toxins.&nbsp;&nbsp; In that case, can I add clay and diatomaceous earth to my green smoothies without fear of wasting any nutrition?&nbsp;&nbsp;&nbsp;&nbsp;I take so many herbs and supplements throughout the day that it is hard to find the time to take these apart from other supplements.<br />
<br />
Thanks <img src='http://www.longecity.org/forum/public/style_emoticons/default/smile.png' class='bbc_emoticon' alt=':)' />]]></description>
		<pubDate>Tue, 21 May 2013 23:11:00 +0000</pubDate>
		<guid>http://www.longecity.org/forum/topic/63709-diatomaceous-earth-and-clay-with-greens/</guid>
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		<title>Hello new user here!</title>
		<link>http://www.longecity.org/forum/topic/63707-hello-new-user-here/</link>
		<description>Been a long time reader but first time poster!</description>
		<pubDate>Tue, 21 May 2013 19:49:26 +0000</pubDate>
		<guid>http://www.longecity.org/forum/topic/63707-hello-new-user-here/</guid>
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		<title>How much Jatamansi/Spikenard should I take?</title>
		<link>http://www.longecity.org/forum/topic/63706-how-much-jatamansispikenard-should-i-take/</link>
		<description><![CDATA[I'm currently taking 2 grams twice a day. Should I adjust this dosage? I keep trying to find information on this herb (especially dosage), but I'm not finding much.]]></description>
		<pubDate>Tue, 21 May 2013 19:43:02 +0000</pubDate>
		<guid>http://www.longecity.org/forum/topic/63706-how-much-jatamansispikenard-should-i-take/</guid>
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	<item>
		<title>Hologram?</title>
		<link>http://www.longecity.org/forum/topic/63704-hologram/</link>
		<description><![CDATA[What could be said about the Holographic universe theory by Craig Hogan, and similar proposals by L. Susskind?<br />
Do these Theories really state, as some magazines suggest, that the universe is only 2 dimensional, or is that just a mathematical simplification to explain certain phenomena?<br />
<br />
Can the universes have less then 3 dimensions?<br />
Would gravity work in such an universe the same way as we know it?<br />
<br />
What do you think?]]></description>
		<pubDate>Tue, 21 May 2013 19:35:46 +0000</pubDate>
		<guid>http://www.longecity.org/forum/topic/63704-hologram/</guid>
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		<title>Achieving permanent changes</title>
		<link>http://www.longecity.org/forum/topic/63703-achieving-permanent-changes/</link>
		<description><![CDATA[Has anyone here demonstrably improved their executive function and fluid intelligence? What I mean by demonstrably is that you've made at least some effort in detailing your progress while <span class='bbc_underline'>abstaining</span> from nootropic use. (DNB, reading speed, IQ testing, etc) <br />
<br />
I'd be interested to find out your experiences.]]></description>
		<pubDate>Tue, 21 May 2013 15:46:01 +0000</pubDate>
		<guid>http://www.longecity.org/forum/topic/63703-achieving-permanent-changes/</guid>
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		<title>5-MTHF aka l-methylfolate (trademarked as Metafolin or Deplin).</title>
		<link>http://www.longecity.org/forum/topic/63698-5-mthf-aka-l-methylfolate-trademarked-as-metafolin-or-deplin/</link>
		<description><![CDATA[5-MTHF aka l-methylfolate (trademarked as Metafolin or Deplin).<br />
<br />
There seems to be a lack of popularity/threads for this supplement on Longecity, and considering it's importance for a large group of people, I thought I would make a thread dedicated for it.<br />
<br />
I will put some important information I found on this site: <a href='http://mthfr.net' class='bbc_url' title='External link' rel='nofollow external'>http://mthfr.net/</a><br />
<br />
So basically, some people have an MTHFR gene mutation:<p class='citation'>Quote</p><div class="blockquote"><div class='quote'>The MTHFR gene is responsible for making a functional MTHFR enzyme. If the MTHFR gene is slightly altered (mutated), the MTHFR enzyme's shape becomes distorted. Enzyme function depends a lot on shape. It is similar to the grooves on a key. If the grooves on a key are slightly different than the lock, the key may fit and turn the lock a little but it does not unlock the door.</div></div><p class='citation'>Quote</p><div class="blockquote"><div class='quote'>In heterozygous MTHFR mutations, only 0.000098% of the MTHFR gene is mutated. In homozygous MTHFR mutations, the value is basically the same.</div></div><p class='citation'>Quote</p><div class="blockquote"><div class='quote'>The most common MTHFR gene mutations are found at position 677 and/or position 1298 on the MTHFR gene.</div></div>
There are a lot of diseases that may be caused by this MTHFR gene mutation, in particular: depression, bipolar and schizophrenia. Here's a link for the full list:<br />
<a href='http://mthfr.net/mthfr-mutations-and-the-conditions-they-cause/2011/09/07/' class='bbc_url' title='External link' rel='nofollow external'>http://mthfr.net/mth...use/2011/09/07/</a><br />
<br />
People that have this mutation (MTHFR C677T) have difficulty processing folic acid to methylfolate:<br />
<span rel='lightbox'><img src='http://i.imgur.com/iVgj7hg.jpg' alt='Posted Image' class='bbc_img' /></span><br />
<br />
By taking a methylfolate supplement, you're directly skipping the processing and giving your brain the end product.<br />
<br />
How can you know if you have this mutation? 23andme.com is one way. I haven't done it myself because it's expensive to ship to Europe (100$ shipping cost), but I already ordered LEF L-methylfolate 1000mcg and will see if it helps.]]></description>
		<pubDate>Tue, 21 May 2013 08:28:00 +0000</pubDate>
		<guid>http://www.longecity.org/forum/topic/63698-5-mthf-aka-l-methylfolate-trademarked-as-metafolin-or-deplin/</guid>
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		<title>new around here</title>
		<link>http://www.longecity.org/forum/topic/63697-new-around-here/</link>
		<description><![CDATA[Hello eveyone.<br />
<br />
I am new here although I've been reading the forum for a while.<br />
<br />
I live in London and am an university student really interested in nootropics, nutrition and healthy lifestyle.<br />
<br />
Hope I wil lcontirbute positively to the forum.<br />
<br />
<br />
Thanks <img src='http://www.longecity.org/forum/public/style_emoticons/default/smile.png' class='bbc_emoticon' alt=':)' />]]></description>
		<pubDate>Tue, 21 May 2013 07:44:01 +0000</pubDate>
		<guid>http://www.longecity.org/forum/topic/63697-new-around-here/</guid>
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		<title>Possibly ADD?</title>
		<link>http://www.longecity.org/forum/topic/63696-possibly-add/</link>
		<description><![CDATA[I'm trying to figure out whether&nbsp;&nbsp;or not I have ADD, I took a few quizs and questionnaires online. From those who have been diagnosed with ADD. do you also have these symptoms or am I just being paranoid? Also I'm still in high school, and I want to be sure I don't have it before I start 12th grade.<br />
<br />
So for symptoms......<ul class='bbc'><li>Can't focus on a book unless I'm really interested (thinking about what I'm gonna do tomorrow in the middle of a page)<br /></li><li>Constantly day dreaming in school&nbsp;&nbsp;(makes up most of my school day lol and not just at school, just about anywhere)<br /></li><li>Tune out in conversations alot (someone can be talking to me and I start looking at whats behind them)<br /></li><li>Minor mistakes(such as forgetting the semi colon when coding .just little things like that)<br /></li><li>Really bad procrastination (even when I try to do something early I always end up doing it last minute, all most as if a wall is there)<br /></li><li>Messy (room,book bag, binder all messy)</li></ul>]]></description>
		<pubDate>Tue, 21 May 2013 04:21:33 +0000</pubDate>
		<guid>http://www.longecity.org/forum/topic/63696-possibly-add/</guid>
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		<title>CES Device</title>
		<link>http://www.longecity.org/forum/topic/63695-ces-device/</link>
		<description><![CDATA[Hello,<br />
First let me apologize in advance if this post has found itself in the wrong portion of the forum.  I promise that I had a good look around before I chose to post here.<br />
I wanted to take a moment to talk about the CES device that I use on a regular basis and about many of the benefits that I have been able to reap from it's use. Cranial Electro Stimulation (or CES) is done primarily with a device of low voltage (9v) and varying frequency (1hz to 100hz). These devices are used for many different purposes one of it's uses is for stress management and focus. I use it as a focus aid. When reading a large sheet of facts or specification I will do so with the help of CES in order to stay in "The Zone" (Cliché I know!) I find that this is doing nothing more than allowing me to recall these facts easier by recalling the feeling of the device and therefore remembering what I was reading while using it. I also use custom made audio programs with CES while I am in a meditative state. Many things can be achieved by this but that is a topic for another time.<br />
<br />
Here are some photos of the device that I have. I will gladly answer any questions there may be about it or it's use.<br />
<a class='resized_img' rel='lightbox[588379]' id='ipb-attach-url-11176-0-13980200-1369489619' href="http://www.longecity.org/forum/index.php?app=core&module=attach&section=attach&attach_rel_module=post&attach_id=11176" title="astral Proj.jpg - Size: 156.2K, Downloads: 14"><img itemprop="image" src="http://www.longecity.org/forum/uploads/monthly_05_2013/post-29086-0-69430600-1369106410_thumb.jpg" id='ipb-attach-img-11176-0-13980200-1369489619' style='width:150;height:200' class='attach' width="150" height="200" alt="astral Proj.jpg" /></a>
<br />
<br />
<a class='resized_img' rel='lightbox[588379]' id='ipb-attach-url-11177-0-15601500-1369489619' href="http://www.longecity.org/forum/index.php?app=core&module=attach&section=attach&attach_rel_module=post&attach_id=11177" title="aproj3.jpg - Size: 155.16K, Downloads: 15"><img itemprop="image" src="http://www.longecity.org/forum/uploads/monthly_05_2013/post-29086-0-46393800-1369106461_thumb.jpg" id='ipb-attach-img-11177-0-15601500-1369489619' style='width:150;height:200' class='attach' width="150" height="200" alt="aproj3.jpg" /></a>
<br />
<br />
<a class='resized_img' rel='lightbox[588379]' id='ipb-attach-url-11178-0-15615600-1369489619' href="http://www.longecity.org/forum/index.php?app=core&module=attach&section=attach&attach_rel_module=post&attach_id=11178" title="aproj2.jpg - Size: 177.25K, Downloads: 12"><img itemprop="image" src="http://www.longecity.org/forum/uploads/monthly_05_2013/post-29086-0-54432600-1369106510_thumb.jpg" id='ipb-attach-img-11178-0-15615600-1369489619' style='width:200;height:150' class='attach' width="200" height="150" alt="aproj2.jpg" /></a>
]]></description>
		<pubDate>Tue, 21 May 2013 03:22:24 +0000</pubDate>
		<guid>http://www.longecity.org/forum/topic/63695-ces-device/</guid>
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		<title>Dietary Fats and Health</title>
		<link>http://www.longecity.org/forum/topic/63684-dietary-fats-and-health/</link>
		<description><![CDATA[Haven't had a chance to read through it yet, although the abstract makes me hesitant to even link it over. Perhaps something interesting is contained within, however.<br />
<br />
<a href='http://advances.nutrition.org/content/4/3/294.full' class='bbc_url' title='External link' rel='nofollow external'>http://advances.nutrition.org/content/4/3/294.full</a>]]></description>
		<pubDate>Mon, 20 May 2013 16:47:05 +0000</pubDate>
		<guid>http://www.longecity.org/forum/topic/63684-dietary-fats-and-health/</guid>
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		<title>A Review of Research Suggesting Retirement is Bad For Health</title>
		<link>http://www.longecity.org/forum/topic/63685-a-review-of-research-suggesting-retirement-is-bad-for-health/</link>
		<description><![CDATA[<p>A recent <a href=http://www.iea.org.uk/sites/default/files/in-the-media/files/Work%20Longer,%20Live_Healthier.pdf>publication by the Institute of Economic Affairs (PDF format)</a> looks at studies that suggest retirement leads to worse long-term health and shorter remaining life expectancy. You'll find the meaningful discussion on how researchers went about trying to identify cause and effect in the PDF rather than the press article quoted below: does the data actually show that retirement causes worsening health versus a tendency for people with worsening health to retire, for example?</p>

<blockquote><i>A study out of the U.K. suggests that while it may provide an initial sense of relief and well-being, over the long-term, retirement is bad for your health, increasing the likelihood of developing depression and at least one physical illness. The study's author [analyzed] data from a survey of 11 European countries that sampled 7,000 to 9,000 people between the ages of 50 and 70 using two separate methodologies. He found that retirement had a "consistent negative impact" on physical health that worsens as the number of years spent in retirement increase.

<p>[The author] also analyzed past studies on the subject of retirement and health and found that their results were mixed, with some finding a positive impact and others a negative or neutral one. The researcher attributes these varied results largely to a failure to distinguish short-term effects from long-term ones and to take the length of retirement into account. In the short term, retirees may experience a boost to health, he says, but this is outweighed by the negative impacts that manifest over the medium and long term.</p>

<p>[The author] acknowledges that there are many variables in any one individual's retirement that can often have contradictory effects on physical and mental health. Retirement can decrease work-related pressures and stress, for example, but it can also cut retirees off from the social networks they formed at work and lead to greater isolation, which can negatively affect health. By contrast, it can lead to more leisure time, which can result in new non-work-related social contacts or more participation in physical activities that positively affect health and well-being. "Untangling cause and effect in the relationship between retirement and health is very difficult. Whereas the short-term impacts of retirement on health is somewhat uncertain, the longer-term effects are consistently negative and large."</i></blockquote></p>

<p><span class="newslink">Link: <a href="http://www.cbc.ca/news/business/story/2013/05/16/business-retirement-health.html">http://www.cbc.ca/news/business/story/2013/05/16/business-retirement-health.html</a></span></p>

<br /><br />&lt;br&gt; &lt;br&gt;<a href='http://www.fightaging.org/archives/2013/05/a-review-of-research-suggesting-retirement-is-bad-for-health.php' class='bbc_url' title='External link' rel='nofollow external'>View the full article</a>]]></description>
		<pubDate>Mon, 20 May 2013 13:44:54 +0000</pubDate>
		<guid>http://www.longecity.org/forum/topic/63685-a-review-of-research-suggesting-retirement-is-bad-for-health/</guid>
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		<title>Muscle twitches after Piracetam use?</title>
		<link>http://www.longecity.org/forum/topic/63681-muscle-twitches-after-piracetam-use/</link>
		<description><![CDATA[Hi everyone,<br />
<br />
In January this year I tried a regimen of Piracetam, and have since experienced muscle twitches.<br />
<br />
My experiment with Piracetam went on for about one month, and during the time I tried to find my "optimal dose" by doing anything between 800 mg - 4800 mg per day. Since I never really found that Piracetam worked for me, I quit cold turkey after my package had run out, towards the end I did about 1600 mg per day before quitting.<br />
<br />
A few days into this regimen, I started getting more and more muscle twitches, that to this day (five months later) have persisted - happening almost constantly throughout the day at different places on the body. The spots seem to be pretty random, although I recognise that some of them are more common than others; especially my left thigh.<br />
<br />
The twitches aren't violent in any way, they're just kinda normal "twitches" that anyone would have, except the frequency and duration has increased a lot. For instance, on my left thigh, multiple times per day I will have a period where a certain muscle will do quick "bubbles" of twitching constantly, which will go on and off for maybe 10 minutes and then stop. And perhaps resume a few hours later. And between those hours I will have random twitches and short "bubblings" at other places that lasts for about 0.5 - 1 seconds.<br />
<br />
The first time I recall the the twitches actually starting was on the second day of trying out Piracetam; I took 1600 mg of Piracetam, 300 mg of AlphaGPC and 50 mg of caffeine. This made me light-headed and a bit nervous, as well as got my nose twitching intensely for a few days. After that I havn't touched AlphaGPC or caffeine again, but the twitches have continued on other parts of the body.<br />
<br />
Also, last month, I also had a bit of a traumatic incident where two nightclub bouncers grabbed me (thinking I had done something I hadn't), and forced me up against a wall. The next day, I started having a twitching in my right eyelid for about a week before it resided.<br />
<br />
My question is: Can these twitches be related to beginning using Piracetam, and/or quitting cold turkey (even though I quit five months ago)? Even though the twitches aren't seizure-like or violent, should I be concerned and perhaps visit a neurologist?<br />
<br />
I havn't changed any other routines in my life during this period, such as diet or exercise. I'm not stressed out at the moment, nor use caffeine or nicotine or alcohol (just drinks once a month).<br />
<br />
Thank you for any help.]]></description>
		<pubDate>Mon, 20 May 2013 13:03:50 +0000</pubDate>
		<guid>http://www.longecity.org/forum/topic/63681-muscle-twitches-after-piracetam-use/</guid>
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		<title>ayahuasca holiday south America</title>
		<link>http://www.longecity.org/forum/topic/63680-ayahuasca-holiday-south-america/</link>
		<description>Anybody know the best place to go?</description>
		<pubDate>Mon, 20 May 2013 11:30:19 +0000</pubDate>
		<guid>http://www.longecity.org/forum/topic/63680-ayahuasca-holiday-south-america/</guid>
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		<title>Dealing With The Stress of a Dying Loved One.</title>
		<link>http://www.longecity.org/forum/topic/63678-dealing-with-the-stress-of-a-dying-loved-one/</link>
		<description><![CDATA[Well here I am, back four months later and no good news.. For those of you who don't know about my situation <br />
<br />
<a href='http://www.longecity.org/forum/topic/61293-17-year-old-male-and-i-would-love-some-advice-may-be-in-wrong-section-too/' class='bbc_url' title=''>http://www.longecity.org/forum/topic/61293-17-year-old-male-and-i-would-love-some-advice-may-be-in-wrong-section-too/</a><br />
<br />
 or are too busy to read it, I am a 17 year old male who's father was diagnosed with stage four prostate cancer metastasized to his bones one year ago, given 1-3 years. He is now in the latter part of stage 4 and doctors have stopped treatment, preparing for his death. - I am here to ask what the hell I can do to get through this myself, for my own well being and the well being of my family. I have never experienced a death before, but I can imagine it's one of the worst possible pains and I am very afraid to face it..&nbsp;&nbsp;If you were in this situation, what would you do to 'better' it for yourself? I know I should spend as much time with him as possible, but I'm talking about things I should do myself to negate some of the stress etc..<br />
<br />
Advice, experiences, ideas on what to take (as stress can be very tolling) anything is welcome. <br />
<br />
Thanks.]]></description>
		<pubDate>Mon, 20 May 2013 02:03:19 +0000</pubDate>
		<guid>http://www.longecity.org/forum/topic/63678-dealing-with-the-stress-of-a-dying-loved-one/</guid>
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		<title>Novel neurotrophic drug based on curcumin published</title>
		<link>http://www.longecity.org/forum/topic/63676-novel-neurotrophic-drug-based-on-curcumin-published/</link>
		<description><![CDATA[Anybody read anything about the neuroprotective and (purportedly) nootrophic synthetic curcumin analog/fragment <span style='color: #333333'><span style='font-family: arial, sans-serif'><span style='font-size: 12px;'><span style='background-color: rgb(239, 239, 239)'>J147?</span></span></span></span><br />
<br />
<br />
<strong class='bbc'>	<span style='font-size: 18px;'><span style='font-family: georgia, serif'><a href='http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0027865' class='bbc_url' title='External link' rel='nofollow external'>J147: A Novel Neurotrophic Drug for Cognitive Enhancement and Alzheimer's Diseas</a>e</span></span></strong><br />
<br />
<br />
<br />
I have been meaning to post this article on here for a few months now to see what the other folks on here make of it.<br />
<br />
The article is quite positive, although I have to say that I'm a little bit surprised that an analogue of a compound known primarily for its anti-inflammatory and anti-oxidant properties would also turn out to up-regulate BDNF!]]></description>
		<pubDate>Mon, 20 May 2013 00:56:24 +0000</pubDate>
		<guid>http://www.longecity.org/forum/topic/63676-novel-neurotrophic-drug-based-on-curcumin-published/</guid>
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		<title>First carnitine, now phosphatidyl choline linked to heart disease</title>
		<link>http://www.longecity.org/forum/topic/63674-first-carnitine-now-phosphatidyl-choline-linked-to-heart-disease/</link>
		<description><![CDATA[For people like myself with a family history of heart disease, choline supplementation might not be advisable<br />
<br />
<br />
<strong class='bbc'>	<span style='font-family: georgia,serif'><span style='font-size: 14px;'><a href='http://www.bbc.co.uk/news/health-22042995' class='bbc_url' title='External link' rel='nofollow external'>"Red meat chemical 'damages heart', say US scientists</a></span></span><span style='color: #222222'><span style='font-family: georgia, serif'><span style='font-size: 14px;'>"</span></span></span></strong><br />
<br />
<strong class='bbc'>	<a href='http://newhope360.com/breaking-news/first-carnitine-now-lecithin-linked-heart-disease' class='bbc_url' title='External link' rel='nofollow external'><span style='color: #222222'><span style='font-family: georgia, serif'><span style='font-size: 14px;'>"First carnitine, now lecithin linked to heart disease" </span></span></span></a></strong><br />
<br />
Apparently, the metabolism of carnitine by some types of intestinal flora result in the production and elevated serum levels of a compound strongly correlated with increased risk for atherosclerosis and heart disease.<br />
<br />
Unfortunately, using racetams without choline supplementation would be counterproductive for many people.<br />
<br />
<br />
I wish I had a good enough understanding of the absorption mechanics of the various forms of supplemental choline to predict which forms would be less likely to reach the large intestine. Other non-parenteral means of administration might also be an option for some of them. <br />
<br />
Anybody better able to unpack these studies in the context of supplementary ALCAR, alpha GPC choline, etc.?]]></description>
		<pubDate>Mon, 20 May 2013 00:42:35 +0000</pubDate>
		<guid>http://www.longecity.org/forum/topic/63674-first-carnitine-now-phosphatidyl-choline-linked-to-heart-disease/</guid>
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		<title>Beginnings</title>
		<link>http://www.longecity.org/forum/topic/63670-beginnings/</link>
		<description><![CDATA[Hello I'm a computer technician in the us mitary.<br />
<br />
I originally became interested in Nootropic's and found this website to be interesting. I will continue to grow my knowlege in this area. I am a proponent of all Technological advancements and Biological advancements of the human species. I look forward to conversing with like minded individuals.]]></description>
		<pubDate>Sun, 19 May 2013 16:03:49 +0000</pubDate>
		<guid>http://www.longecity.org/forum/topic/63670-beginnings/</guid>
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		<title>test</title>
		<link>http://www.longecity.org/forum/topic/63668-test/</link>
		<description><![CDATA[<strong class='bbc'>Name</strong>: test<br /><strong class='bbc'>Category</strong>: science<br /><strong class='bbc'>Description</strong>: test<br /><br /><a href='http://www.longecity.org/forum/quiz/5-test/' class='bbc_url' title=''>Click here to take this quiz!</a>]]></description>
		<pubDate>Sun, 19 May 2013 14:54:16 +0000</pubDate>
		<guid>http://www.longecity.org/forum/topic/63668-test/</guid>
	</item>
	<item>
		<title>intro</title>
		<link>http://www.longecity.org/forum/topic/63667-intro/</link>
		<description><![CDATA[Hey everyone,&nbsp;&nbsp;glad to be here and able to help contribute to our longevity and to further my knowledge... Specifically interested in Telomere lengthening... I am currently making a batch of AGAG to induce Telomerase and hopefully lengthen Telomeres to a significant degree over the span of the next few years..&nbsp;&nbsp;Will update on progress...]]></description>
		<pubDate>Sun, 19 May 2013 14:19:31 +0000</pubDate>
		<guid>http://www.longecity.org/forum/topic/63667-intro/</guid>
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		<title>The Dark Side of Open-Access: Pseudo-Academia</title>
		<link>http://www.longecity.org/forum/topic/63665-the-dark-side-of-open-access-pseudo-academia/</link>
		<description><![CDATA[Wasn't sure where to post this but the New York Times wrote an article regarding the credibility of certain "journals" that now have come out by means of "open-access". Thus, publishing studies that are questionable. Longecity members beware of what you use as sources!<br />
<br />
<a href='http://www.nytimes.com/2013/04/08/health/for-scientists-an-exploding-world-of-pseudo-academia.html?pagewanted=all&_r=0' class='bbc_url' title='External link' rel='nofollow external'>http://www.nytimes.com/2013/04/08/health/for-scientists-an-exploding-world-of-pseudo-academia.html?pagewanted=all&_r=0</a>]]></description>
		<pubDate>Sun, 19 May 2013 08:27:52 +0000</pubDate>
		<guid>http://www.longecity.org/forum/topic/63665-the-dark-side-of-open-access-pseudo-academia/</guid>
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