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Res and Biological activities


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#1 Hedgehog

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Posted 29 December 2007 - 07:49 AM


I was reading about some of these SIRT1 activators and found the myricetin is the most potent at inhibiting kinases.

Relationship between flavonoid structure and inhibition ofphosphatidylinositol 3-kinase: a comparison with tyrosine kinase andprotein kinase C inhibition.


I also found this in another article. You guy's have probably already talked about this but I hadn't seen it.
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#2 niner

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Posted 30 December 2007 - 05:43 AM

Prevention of LDL peroxidation promotes atherosclerosis?

I get the impression that the concentrations cited are not EC50s or the like... just whatever was used in the experiment. Most of us are unlikely to see plasma concentrations of free resveratrol greater than low single digit micromolar, although questions remain regarding possible concentrating mechanisms.

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#3 Hedgehog

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Posted 02 January 2008 - 06:59 PM

Prevention of LDL peroxidation promotes atherosclerosis?

I get the impression that the concentrations cited are not EC50s or the like... just whatever was used in the experiment. Most of us are unlikely to see plasma concentrations of free resveratrol greater than low single digit micromolar, although questions remain regarding possible concentrating mechanisms.


I think it was whatever the experiment was using. With Regards to the LDL and HDL. It appears that Res binds better with LDL(Bad) thus protecting against oxidation. Res binds to HDL(good), but not with the same affinity as LDL. I agree it would hard to achieve those concentrations.

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#4 niner

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Posted 03 January 2008 - 03:16 AM

Prevention of LDL peroxidation promotes atherosclerosis?

I get the impression that the concentrations cited are not EC50s or the like... just whatever was used in the experiment. Most of us are unlikely to see plasma concentrations of free resveratrol greater than low single digit micromolar, although questions remain regarding possible concentrating mechanisms.


I think it was whatever the experiment was using. With Regards to the LDL and HDL. It appears that Res binds better with LDL(Bad) thus protecting against oxidation. Res binds to HDL(good), but not with the same affinity as LDL. I agree it would hard to achieve those concentrations.

I'm still confused about how prevention of LDL peroxidation would promote atherosclerosis. I thought that lipid peroxidation was a bad thing...




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