40 replies to this topic

[Athanasios]

Doubt I can find the exact one again, it was a fluke that I ran across it in the first place. Maybe google would be an easier way to find the info as in pubmed it is like a needle in a haystack. Such as this google book: http://books.google....q...lt&resnum=2 (go back one page to p.39 for a chart and forward to 41 for references)

Thought I would add this too:

J Agric Food Chem. 2007 Mar 21;55(6):2489-96.
Enhanced absorption of anthocyanins after oral administration of phytic acid in rats and humans.

Matsumoto H, Ito K, Yonekura K, Tsuda T, Ichiyanagi T, Hirayama M, Konishi T.
Food and Health R&D Laboratories, Meiji Seika Kaisha, Ltd., 5-3-1, Chiyoda, Sakado-shi, Saitama 350-0289, Japan. hitoshi_matsumoto@meiji.co.jp
Many studies on the bioavailability of polyphenols have been reported. However, the relative urinary excretions of AC are also low, ranging from 0.004% to 0.1%. By contrast, other polyphenols show higher urinary excretion levels. Here, we studied the enhancing effects of phytic acid (IP6) on absorption of blackcurrant anthocyanins (BCAs) in rats and humans. In rats after oral administration of BCAs (as 241 mg of AC/kg body weight) in IP6 (0%, 0.25%, 0.5%, 1%, 2.5%) solution, the ACs recovery in urine was increased dependent on IP6 dose. These results suggest that the IP6 enhances gastrointestinal absorption of ACs. At the further analysis of IP6 enhancement effect in rat, whereas BCAs were normally passed through the stomach and duodenum within 2 h, in IP6 group, after 2-6 h post-administration, stomach and jejunum content's weights were specifically heavy, and large amounts of ACs were also detected in stomach, duodenum, and jejunum. These results suggested that the mixture of BCAs and IP6 reduced the gastrointestinal motility. Prolongation of ACs residue in gastrointestinal tract then caused the enhancing effects of IP6 on absorption of AC. In the human study, each subject was orally administrated a BCA beverage containing BCA concentrate (AC 4 mg/kg body weight), 1% of IP6, and 1% of sodium citrate as a pH stabilizer. Both the plasma level and the urinary excretion of AC were increased as compared to BCA administration without IP6. AC intake with IP6 may increase the bioavailability of AC to the comparative level as other polyphenols. Yet, phytic acid, being a strong chelator of important minerals, contributes to mineral deficiencies. An interference with iron uptake has been reported. Safety tests are therefore necessary before high dose IP6 can be used in foods.

PMID: 17319688

Edited by cnorwood, 17 July 2009 - 01:26 AM.

[livingguy]

I take it in a more intense fashion on a need basis. When I am on it I take about 3-4 grams a day in two divided doses. One around 11:00 AM and the other around 6 PM. I take it to keep my ferritin levels in check. I check my ferritin levels regularly and it works.

[albedo]

Two very good videos on the benefit of phytate (IP6) both as cancer prevention and cancer treatment:

http://nutritionfact...tment-of-cancer
http://nutritionfact...ntion-of-cancer
 

I am taking 800 mg at night just before bed. Very good effect on my ferritin level. Take it at empty stomach and away from other supplements.

By the way, I would recommend to register to Dr. Michael Greger website to receive up-to-date nutrition information.

 

[Dorian Grey]

2 great clips albedo...  IP6 has been my fountain of youth supplement for several years now.  

 

I used to have to donate blood fairly aggressively to keep ferritin from creeping up past 50, but just one (500mg) IP6/Day on an empty stomach with a full glass of plain water allowed me to cut back on donating to a couple of times/year.  

 

I do cycle-off 2 days a week, and one week every month or so.  

 

Dark bags under eyes, gone.

Silvery hair at temples, brown again.

Red blotchy skin, a more youthful shade of pale.

Liver enzymes down in the teens.  

 

My God, I'm young again!  

[albedo]

I just pop into this (quite) old study explaining the IP6 chemio-prevention of cancer via TPA- or EGF induced cell transformation through its effects on PI-3 kinase. I am keeping taking 800 mg/d at empty stomach before bed time.

 

PI-3 kinase in signal transduction, cell transformation, and as a target for chemoprevention of cancer.

 

Abstract

Phosphatidylinositol-3 kinase (PI-3 K) plays a central role in a broad range of biological effects. However, little is known about its role in phorbol ester- or epidermal growth factor (EGF)-induced signal transduction to the transcriptional machinery of the nucleus and in tumor promoter-induced cell transformation. We have used JB6 cells to study the role of PI-3 K in 12-O-tetradecanoylphorbol-13-acetate (TPA)- or EGF-induced AP-1 activation and neoplastic cell transformation. We demonstrated that TPA, EGF and insulin induce PI-3 K activity in JB6 cells. The induced PI-3 K activity was blocked by a dominant negative mutant of PI-3 K, and by wortmannin or LY294002. Blocking of PI-3 K activity by these inhibitors also blocked TPA- or EGF-induced AP-1 activity and cell transformation. Furthermore, we have investigated the role of PKC and its isozymes in the synergistic induction of PI-3 K by TPA and insulin and found that bisindolylmaleimide, a PKC inhibitor, inhibits TPA-induced PI-3 K. Overexpression of a dominant negative PKC epsilon, but not dominant negative PKC alpha, blocks the TPA- or TPA plus insulin-induced PI-3 K activity. Inositol hexaphosphate (InsP6) is one of the most promising chemopreventive agents as demonstrated by Shamsuddin et al. and others. InsP6 profoundly inhibits EGF- or TPA-induced cell transformation and the signal transduction cascade to Erks and AP-1 activation. InsP6 also inhibits TPA- or EGF-induced PI-3 K activity in vivo and in vitro. These results suggest that the anticarcinogenesis action of InsP6 may be through inhibition of PI-3 K and inhibition of the AP-1 pathway. Because InsP6 is a naturally occurring compound with virtually no toxicity, and may be an effective anticarcinogenesis agent in humans, PI-3 K and AP-1 activities may be useful biomarkers for the effectiveness of InsP6 in clinical studies.

http://www.ncbi.nlm....pubmed/10625951

[albedo]

Excellent review (2005, free access) on IP6 preventive and beneficial role for one of my concern. It confirms also previous results:

 

Prostate Cancer and Inositol Hexaphosphate: Efficacy and Mechanisms

http://ar.iiarjourna...25/4/2891.short

 

From the conclusions:

"...In summary, the naturally occurring carbohydrate IP6 possesses mechanism-based in vitro as well as in vivo anticancer efficacy against PCA. More importantly, oral IP6 is found to be non-toxic in animal studies as well as to nonneoplastic human prostate epithelial cells in culture. Additionally, the vast experimental evidence for the antineoplastic efficacy of IP6 in various other cancers supports its merit for clinical development as a cancer chemopreventive agent. It could be suggested that dietary intervention of PCA by IP6 might be useful in slowing down the growth and progression of the disease in aging males, which would reduce the associated morbidity and mortality, as well as the burden of PCA management on health care systems. IP6 could also be clinically relevant for the human population at high risk of developing PCA as well as those with different stages of this malignancy. Overall, based on its properties, including non-toxicity, high efficacy, low cost and human acceptability, we suggest the promise and potential of IP6 as an ideal preventive and/or therapeutic agent against prostate cancer..."

[hav]

I tend to take it as needed. Like if I experience any lower back or urinary tract discomfort. Or in conjunction with something like an mri or ct scan using a contrast enhancer... a few days of ip6 in advance tends to yield really good numbers in the preceding kidney function tests. When I take it I do it in the middle of the night on an empty stomach with chilled water, every couple of hours or so till morning drinking at least 16 oz which helps wake me up to pee and repeat.  Typically every few months for maybe a couple of days to a week straight.

 

Howard

[albedo]

That is informative Hav. I realize the impact on preventing kidney stones (which btw, I also had in my life) but the reasons why I am taking it (so far 800 mg on empty stomach just before going to bed) are related in particular to the lowering effect on my ferritin level. I just wonder if you know about other ways, beside kidney stones, IP6 could potentially be beneficial to kidney health. So far IP6 is probably one of the best decision I take in supplementation. Thank you for sharing.

[SearchHorizon]

I used to take IP6 for about 9 months, 1-2 g/daily.

 

Over time, I saw my exercise capacity diminished, increased cramps, increased injuries, decreased light sensitivities, may have contributed to whitening of my hair, etc. Perhaps, IP6 inhibits cancer, but it also seems to curb normal, healthy functions in my body. Without direct evidence, I cannot be 100% sure IP6 caused all this. I am pretty careful about monitoring parameters, however, and I am reasonably sure that the culprit was IP6. I was also dieting at the time, and this may have resulted in over-the-top autophagy.  

 

It took me a while to get back from this state.

 

I think IP6 does induce autophagy, but indiscrimately. I don't think it is a good thing.

 

 

Edited by SearchHorizon, 22 May 2016 - 03:59 AM.

[Dorian Grey]

I believe the diminished exercise capacity.  When I take half a gram in the morning without eating, I notice my fire burns with slightly less intensity until after I have lunch.   Never been into intense workouts, so I've never really ran out of steam.  I still climb the 100 stairs over the convention center after lunch for my hike along the waterfront.  

 

I'm curious about the "decreased light sensitivities".  Are you referring to night (or low light) blindness?  Increased injuries?  What kind.  Haven't noticed this myself.  

 

My hair has also stayed nicely brown, even as I approach my 60th birthday this year.  My hair was actually getting a bit silvery at the temples about 15 years ago, but strangely reverted to brown after starting on a few supps and donating blood to lower iron.  I was taking NAC with C back then when I reversed my gray, but got spooked off NAC by the reports of pulmonary hypertension.  Swapped the NAC for IP6 around 5 years ago and my hair is still holding largely brown.  

 

I've never taken more than a gram a day spaced 12 hours or so apart, but have cycled off and on for over 5 years now.  Thanks for the input, and I'll watch more closely for these issues.  

[SearchHorizon]

I'm curious about the "decreased light sensitivities".  Are you referring to night (or low light) blindness?  Increased injuries?  What kind.  Haven't noticed this myself.  

 

Good stuff on hair color - thanks for the feedback.

 

As for light sensitivity, I was talking about acceleration of the onset of age-related, decreased sensitivity to light. This is fairly easy to detect - Say that you are looking at a automobile front dashboard with LED (e.g., for clock) during daytime. While I was on IP6, it came to have much more difficult to read, as LED seemed to become less and less luminous. Before, I had no problem seeing the LED.

 

As for injuries, these generally happened during exercise. Frequency of injuries began to creep up during my high intensitiy training, such that I had to stop the exercises (High intensity exercises are very taxing to the body even after the exercise if over). These were usually pulled muscle in my calves, arches, etc. Now, I don't have them any more. One interesting type of injury was an issue with my back. A day or two after a hard lifting session, my back would go out with great frequency. Now that I am no longer taking IP6, that has stopped.

 

I think if you are careful about supplementing, IP6's potentially harmful effects can be managed (e.g., replenishing some micronutrients that could be lost during autophagy). Also, it is probably a good idea to go for a lower dosage - mine was probably too high.

 

Dr. Sardis has espoused the idea that accumulation of harmful minerals in our cells is the culprit behind our biological aging. I used to believe, to some extent, that was the case. Now, I think that view is not correct - our body is not a mechanical machine. I think the accumulation of calcium and iron is not the cause of aging/deterioration, but a consequence. Basically, our body becomes bad at "partitioning" (that is, becomes inefficient at sending each type of micro or macro nutrient to proper destination tissue). So, things end up at wrong tissues (e.g., calcification of brain tissue).