A recent study from Maria Blasco's labTelomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer
A major goal in aging research is to improve health during aging. In the case of mice, genetic manipulations that shorten or lengthen telomeres result, respectively, in decreased or increased longevity. Based on this, we have tested the effects of a telomerase gene therapy in adult (1 year of age) and old (2 years of age) mice. Treatment of 1- and 2-year old mice with an adeno associated virus (AAV) of wide tropism expressing mouse TERT had remarkable beneficial effects on health and fitness, including insulin sensitivity, osteoporosis, neuromuscular coordination and several molecular biomarkers of aging. Importantly, telomerase-treated mice did not develop more cancer
than their control littermates, suggesting that the known tumorigenic activity of telomerase is severely decreased when expressed in adult or old organisms using AAV vectors. Finally, telomerase-treated mice, both at 1-year and at 2-year of age, had an increase in median lifespan of 24 and 13%
, respectively. These beneficial effects were not observed with a catalytically inactive TERT, demonstrating that they require telomerase activity. Together, these results constitute a proof-of-principle of a role of TERT in delaying physiological aging and extending longevity in normal mice through a telomerase-based treatment, and demonstrate the feasibility of anti-aging gene therapy.https://www.ncbi.nlm...les/PMC3494070/
Why has everybody been silent since the last month? Any better topic to discuss?
There have been periods with low activity in this thread in the past, maybe the activity will be higher again during the holidays.
I will do my next health check and telomere test in the beginning of the new year. I've also added "2 x Micronized Resveratrol 250mg" to my regimen in order to see if it makes a difference.
Edited by GreenPower, 22 December 2012 - 07:04 AM.