mikeinnaples, on Dec 8 2009, 03:39 AM, said:
So the consensus now is A4 does nothing?
A4 is proven to be a telomerase activator, but we do not know how potent it is.
Scierra sciences, a company that is reasearching for telomerase inducers states
As of November 24th, 2009:
We have screened 168,992 compounds
We have found 506 telomerase inducers
These represent 33 distinct drug families
Most potent compound = 6% of goal
Sierra sciences has independently testested TA-65 (stated in tasciences.com), and TA-65 compound is very probably included in that list.
A compound that is not very effecient does not mean it doesn't work at all, but a higher blood concentration/dosage will be needed to achieve the same results of a more effective compound at significant lower dosage.
Higher dosage means a potentially increased risk of side effects in vivo. This is probably why TA-sciences started by prescribing 5mg of TA65.
They upped the dosage from 5mg to 100mg
(20x) which means:
1. Compound had no side effects at that dosage.
2. Compound concentration inside somatic cells was not enough to give results.
This is for sure, no one would up the dosage by 20x of something that works the way it should.
I agree with Anthony, TA-65 could very well be A4.
And there is a big chance that TA65/A4 is not the most potent compound out there.
Cycloastragenol could be for example a little more potent than A4.
you have tried A4 @100mg/day for 6 months without experiencing any results, did you test telomeres length before and after the treatment?
100mg might still be not enough, but if you didn't experience any side effects this is in fact a very good news because it means that people at ta-sciences could up the dosage again if it is still not enough to reach the goal.
Question is, how much of A4-supplementation is it needed to do the job before incurring in side effects that will inevitably occour beyond a certain point?
I do not think that intergrating A4 with a little bit of cycloastragenol will have any benefit, as long as cycloastragalus does not promote A4 absorption.
A4 and cycloastragenol are two different molecules
and their passive diffusion inside the cell is concentration-related.
Astragaloside IV is absorbed by typical passive diffusion mechanism.
China journal of Chinese materia medica. 01/08/2008;
In this logic, it is better a higher dosage of a less potent compound (as long as there are no side effects) than adding a bit of a little more potent compound.
But this is the right way to proceed, they slowly up the dosage of the compound they already have as long as there are no side effects, and at the same time they keep looking for a more potent compound that could do the job more efficiently at a significant lower dosage.
Selenium is also known to be a telomerase activator in vitro
Telomerase Activity and Telomerase Reverse Transcriptase Expression Induced by Selenium in Rat Hepatocytes
RI-AN YU, HUA-JIE CHENΔ, LING-FEI HE, BING CHEN and XUE-MIN CHEN
but you would need a even higher dose to make it work that will probably be toxic in vivo.
I think it would be extremely interesting if someone had a high
concentration - A4 topical skin cream, to see if there are some noticeable effects.
Again the concentration of A4 is fundamental.
Edited by kitinje, 09 December 2009 - 03:14 AM.