Good News. Looks like a repeat of the November 2006 study but this time with NCE's. I hope they publish results for mice on normal diets.
The new data will show that mice on a high-fat diet treated with one of Sirtris’ new chemical entities (NCEs) remained lean while consuming the same number of calories as the untreated mice. Mice on the highest dose of the NCE had no weight gain over 13 weeks, and in exercise testing, ran over 1,600 meters before tiring, while the untreated mice tired at roughly 800 meters.
The treated mice also showed lowered glucose, improved insulin sensitivity and increased energy expenditure due to an increase in the number and function of mitochondria, the powerhouses of the cell. These results are similar to a study previously published in the November 2006 issue of Cell by Dr. Auwerx when mice were treated with resveratrol.
“In this study we demonstrated that Sirtris’ new chemical entity stimulates the SIRT1 enzyme, and mimics the powerful effects we’ve seen in earlier studies but with lower dosage levels,” said Auwerx. “This activity provides evidence of a potential new, front-line therapy for Type 2 Diabetes.”