8 replies to this topic

[sUper GeNius]

I have seen this posted elsewhere. What do you all make of it?

http://www.ncbi.nlm....pt=AbstractPlus

Edited by FuLL meMbeR, 29 January 2008 - 01:02 AM.

[malbecman]

Its quite plausible but the overwhelming evidence (published in much better journals with likely stricter peer-review) is against these findings...

I have seen this posted elsewhere. What fo you all make of it?

http://www.ncbi.nlm....pt=AbstractPlus

[lucid]

The title is misleading: the trials were all done by the same lab. I updated the wiki entry for resveratrol a while ago to mention these trials, but I haven't read a good rebuttal to the trial. What seems more critical: what independent studies confirm sinclair's findings?

[niner]

When they say "seven independent trials" do they mean 7 different labs? From reading the abstract it sounds like the same guys tried 7 times. While this result in worms doesn't shock me, there's an awful lot of evidence that resveratrol is doing something good... I'm still waiting on lifespan results for mice on a normal diet, or any mammal on a normal diet. (crickets chirping)

edit: lucid, you beat me to it.

Edited by niner, 29 January 2008 - 02:01 AM.

[sUper GeNius]

The title is misleading: the trials were all done by the same lab. I updated the wiki entry for resveratrol a while ago to mention these trials, but I haven't read a good rebuttal to the trial. What seems more critical: what independent studies confirm sinclair's findings?

yeah, I know, I like headlines that draw you in...

[sUper GeNius]

When they say "seven independent trials" do they mean 7 different labs? From reading the abstract it sounds like the same guys tried 7 times. While this result in worms doesn't shock me, there's an awful lot of evidence that resveratrol is doing something good... I'm still waiting on lifespan results for mice on a normal diet, or any mammal on a normal diet. (crickets chirping)

edit: lucid, you beat me to it.

Didn't Sinclair do those tests already? Didn't someone here say that those mice tests have been published? This whole mice thing bugs me. Who the hell cares about fat mice?

[VP.]

The title is misleading: the trials were all done by the same lab. I updated the wiki entry for resveratrol a while ago to mention these trials, but I haven't read a good rebuttal to the trial. What seems more critical: what independent studies confirm sinclair's findings?

Here is one done on fish that did not involve Dr. Sinclair: http://www.sciencedi...4b1a64d5cc767e4

[missminni]

The title is misleading: the trials were all done by the same lab. I updated the wiki entry for resveratrol a while ago to mention these trials, but I haven't read a good rebuttal to the trial. What seems more critical: what independent studies confirm sinclair's findings?

What doses did they use? It's so vague.

We saw no significant effects on lifespan in seven independent trials. We analysed our resveratrol and found that its structure was normal, with no oxidative modifications. We therefore re-tested the effects of resveratrol in C. elegans, in both wild-type and sir-2.1 mutant worms. The results were variable, with resveratrol treatment resulting in slight increases in lifespan in some trials but not others, in both wild type and sir-2.1 mutant animals

[maxwatt]

The title is misleading: the trials were all done by the same lab. I updated the wiki entry for resveratrol a while ago to mention these trials, but I haven't read a good rebuttal to the trial. What seems more critical: what independent studies confirm sinclair's findings?

What doses did they use? It's so vague.

We saw no significant effects on lifespan in seven independent trials. We analysed our resveratrol and found that its structure was normal, with no oxidative modifications. We therefore re-tested the effects of resveratrol in C. elegans, in both wild-type and sir-2.1 mutant worms. The results were variable, with resveratrol treatment resulting in slight increases in lifespan in some trials but not others, in both wild type and sir-2.1 mutant animals

Without the full paper it's impossible to evaluate, and maybe not even then. FWIW, there is a paper demonstrating that caloric restriction does not extend lifespan in a wild strain of mice. At the end of the paper they speculate they may have over-restricted the mice as the restricted group tended to die young, and even the control group may have been calorically restricted.

It takes a lot of studies before the truth emerges from these experiments.