13 replies to this topic

[Bghead8che]

Has anyone heard of using Magnolia Officinalis (2-5% Honokiol) for anxiety and sleep? If the claims are true it seems to be a fairly potent supplement.

Here are two formulas that use Magnolia and a combination of two other herbs though I don't think the "other" herbs serve any purpose beyond applying for a trademark.

http://www.nextpharm...ora/relora.html
http://www.nextpharm...ol/seditol.html

Here is an article on Magnolia Bark alone, as quote below:

http://www.herbwisdo...b-magnolia.html

Anxiety

In studies, honokiol was compared with diazepam (Valium), a well known pharmaceutical anxiolytic. Honokiol was found to be five times stronger than diazepam in reducing anxiety without the side effects of diazepam. While Diazepam does reduce anxiety, it also induces muscle relaxation, an effect not shared by honokiol. It would seem that honokiol is less likely than diazepam to induce physical dependence, central nervous system depression, motor nerve disruption, or amnesia at doses eliciting the anxiolytic effect. Because honokiol reduces anxiety without disruption of motor activity, it is postulated that the mechanism of the anxiolytic effect of honokiol is at least partially different from that of diazepam.

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Any thoughts on Magnolia as a sleep/anxiety aid? Relora and Seditol are relatively expensive while Magnoliar Bark is not. Do you think that you would get the same results using Magnolia Bark alone? Seems like Magnolia might be a great supplement for insomnia and anxiety.

Thoughts?

-Brian

[niner]

Diazepam is a very powerful anxiolytic. It's hard to believe that magnolia bark is five times more potent. Not impossible to believe, just hard. I don't consider the lack of muscle relaxation to be a plus. That is one of the most useful features of Diazepam.

[yoyo]

Magnolia bark is specifically noted for not being a hypnotic. So probably only good for sleep if it is anxiety that keeps you from sleeping.

[Bghead8che]

Has anyone heard of using Magnolia Officinalis (2-5% Honokiol) for anxiety and sleep? If the claims are true it seems to be a fairly potent supplement.

Here are two formulas that use Magnolia and a combination of two other herbs though I don't think the "other" herbs serve any purpose beyond applying for a trademark.

http://www.nextpharm...ora/relora.html
http://www.nextpharm...ol/seditol.html

Here is an article on Magnolia Bark alone, as quote below:

http://www.herbwisdo...b-magnolia.html

Anxiety

In studies, honokiol was compared with diazepam (Valium), a well known pharmaceutical anxiolytic. Honokiol was found to be five times stronger than diazepam in reducing anxiety without the side effects of diazepam. While Diazepam does reduce anxiety, it also induces muscle relaxation, an effect not shared by honokiol. It would seem that honokiol is less likely than diazepam to induce physical dependence, central nervous system depression, motor nerve disruption, or amnesia at doses eliciting the anxiolytic effect. Because honokiol reduces anxiety without disruption of motor activity, it is postulated that the mechanism of the anxiolytic effect of honokiol is at least partially different from that of diazepam.

-----------------

Any thoughts on Magnolia as a sleep/anxiety aid? Relora and Seditol are relatively expensive while Magnoliar Bark is not. Do you think that you would get the same results using Magnolia Bark alone? Seems like Magnolia might be a great supplement for insomnia and anxiety.

Thoughts?

-Brian

I agree. Hard to believe. Did you get a chance to read the studies on the first two links? It does seem promising.

[yoyo]

What sites you you use to buy herbs like this in bulk?

[Keizo]

I just tried some of Swanson's stuff (90% honokiol 200mg), it does work very well though it might change since this is the first time. This is the closest to benzodiazepine-like effects I've come across. Bacopa feels ratrher different,  this extract of magnolia feels more similar to benzos or alcohol. I notice I have difficulty typing which bacopa doesn't give, but benzos & alcohol can give. Also much more positive feeling than bacopa (I was smiling quite a lot some hour ago), again something which can happen with benzos and alcohol.

This time it is the middle of the day (I took it at 14:30, so 2 hours ago). It doesn't make me feel tired, but then that is my expected reaction with alcohol and benzos as well unless taken at a particular time.

 

I will try it again sometime and see hoiw it works.

 

Edited by Keizo, 15 May 2015 - 02:41 PM.

[adamh]

I've used the combo of magnolia bark and phelodendron. It helps somewhat, not a knockout at all. At least not at the doses I tried which was 1 or 2 caps of each.

[Keizo]

I just tried some of Swanson's stuff (90% honokiol 200mg), it does work very well though it might change since this is the first time. This is the closest to benzodiazepine-like effects I've come across. Bacopa feels ratrher different,  this extract of magnolia feels more similar to benzos or alcohol. I notice I have difficulty typing which bacopa doesn't give, but benzos & alcohol can give. Also much more positive feeling than bacopa (I was smiling quite a lot some hour ago), again something which can happen with benzos and alcohol.

This time it is the middle of the day (I took it at 14:30, so 2 hours ago). It doesn't make me feel tired, but then that is my expected reaction with alcohol and benzos as well unless taken at a particular time.

 

I will try it again sometime and see hoiw it works.

So i have tried it several times now at the same dose. The effects were still noticeable, but milder than that initial dose.

 

It certainly made it harder to walk at full pace when I took it before  long walks. I had too walk much slower, and I noticed I looked down into the ground a lot. It also mimics the feeling of various hypnotic drugs, such as z-drugs and various anti-histamines....a tired unpleasant feeling that showed itself now and then for the rest of the day.

Seems useful. I am not sure if it is so great for daytime for me, gives me mixed impressions (feeling a bit better and just a bit more relaxed, and then an unpleasant tired feeling albeit mild).

Edited by Keizo, 23 May 2015 - 12:26 AM.

[OneScrewLoose]

The study that links the mechanism of Magnolia Bark to the mechanisms of benzos comes from this journal:

 

http://journal.front....00130/abstract
https://www.research...rs_in_Neurology

It's has been around for five years and still has no impact factor. That means no one is citing it, at all. That's a bigger red flag than the one that hung over the Kremlin until 1991.

 

Edited by OneScrewLoose, 23 May 2015 - 10:11 PM.

[ta5]

I've tried a couple different brands of Magnolia Bark on and off over the years and never really noticed anything. I took some crazy high doses too. But, Relora has very noticeable effects. I could never understand. 

[fntms]

I've been taking 3x250mg Relora for less almost a week and am impressed by the calming action without sedation. Very anxiolitic and mood brightening (with no euphoria, just peacefulness, and no dumbing down), a bit like tianeptine used to be for a good while...
No effect on sleep or appetite (yet?)
There might be some gastric and skin issues though, not sure...

[fntms]

Had to stop taking Relora as it was making me dizzy, light headed... I never found it helped sleep at all... Maybe I will just cut down to 1x day.

[Revera]

Magnolia Bark is interesting, Honokiol and Magnolol, two among notable chemicals in Magnola Bark, are actually Ccannabinoids. Similar to THC. One of the metabolites of Magnolol is actually Tetrahydramagnolol. However, they play on the CB2 receptors, more related to analgesia and anti-inflammatory attributes, whereas THC resonates with CB1, which is where the euphoria ('high') and appetite stimulate are based. Hemp might also have CB2's. Neither of these chemicals to be confused with CBD's! Which are in Marijuana like CB's, but are different, they compete with CB1's, and indirectly potentiate them.

 

I checked the NIH (.gov) page on Magnolia Bark for this, and Wikipedia too (opening the Wiki pages for each individual chemical). Cannabinoids are both known to make anxiety worse for some, and better for others. Depends in your makeup.  There's a caymanchem (.com) page for THM, by the way.

 

There might be other active ingredients. I'm still testing it, and a friend with me. There are some metabolites which touch on CB1, but not very much. Hopefully not enough to get it banned, the FDA likes to take away supplements if they are very effective or people abuse them or hype them too much even. Piacmilion and red yeast rice, for example, check out their fate, for simply being effective.

 

Note: it's not very soluable, like THC (hence, smoking or brownies with butter to activate it, not general eating of Marijuana though), it prefers fat and oil. Consume magnolia bark extract, especially when very purified like Lift Mode sells, but even with regular diluted or more natural compilations, with some olive oil or something.

 

This thread is a bit old, sorry to bump it, but, not sure anyone covered these details. There isn't much out there about this. Feel free to update me and others, any of you who were posting here and trying Magnolia, for how things went. Thanks, and hope this information is of some help.

[Jiminy Glick]

Yeah but that is for pure Honokiol extract I think which is expensive. Also I have Magnolia Bark, stopped taking it though because it tastes so bad, might get back on it though.