11 replies to this topic

[cinnabar]

http://www.nutraingr...uiqpxihzrgrkyik

Resvida is a synthetic resveratrol, but is said to be 'nature identical'.

It comes in two forms: a crystalline form, with 99 percent purity; and a tablet grade form, with a purity of 90 percent.

According to DSM, this is the purest form of resveratrol currently found on the marketplace.

Another major selling point that the company is promoting is the safety package surrounding the ingredient, which it claims is unmatched by any other form of resveratrol currently available.

"Previous New dietary ingredient notifications were rejected by the FDA because sponsors did not provide a thorough safety assessment," said DeJianne.

"We have performed a very comprehensive safety analysis around this ingredient. That's why it has taken around ten years of work to bring the product to market."

This is also why DSM is confident its ingredient will successfully compete with other resveratrol products, which have the benefit of being naturally sourced.

[malbecman]

I found this section of the article particularly interesting to all of us resveratrol supplement users:

"DSM will be filing for self-affirmed GRAS (generally recognized as safe) status for Resvida. It hopes to receive this by the second quarter this year, which will open up the market for its use in foods and beverages. In fact, an initial response from Supply Expo indicated high interest from beverage manufacturers, DeJianne told NutraIngredients-USA.com.
The ingredient is not yet completely soluble in water, but DSM said it is "working on" a food formulation. However, DeJianne added that this may not be necessary, as the ingredient is stable.
DSM said it plans to accompany the launch with a comprehensive PR campaign, which it hopes will help build the brand and create consumer awareness."


So just like we confirmed: T-res is stable (stable enough for a food formulation) Also, the GRAS status should help open up a lot of markets for resveratrol products and bring down the price......

[maxwatt]

I found this section of the article particularly interesting to all of us resveratrol supplement users:

"DSM will be filing for self-affirmed GRAS (generally recognized as safe) status for Resvida. It hopes to receive this by the second quarter this year, which will open up the market for its use in foods and beverages. In fact, an initial response from Supply Expo indicated high interest from beverage manufacturers, DeJianne told NutraIngredients-USA.com.
The ingredient is not yet completely soluble in water, but DSM said it is "working on" a food formulation. However, DeJianne added that this may not be necessary, as the ingredient is stable.
DSM said it plans to accompany the launch with a comprehensive PR campaign, which it hopes will help build the brand and create consumer awareness."


So just like we confirmed: T-res is stable (stable enough for a food formulation) Also, the GRAS status should help open up a lot of markets for resveratrol products and bring down the price......

The people introducing it in this press wire are DSM Nutritional Products Ltd. Switzerland.
It's a Swiss company. It's not going to be cheap. I doubt this will bring the price down. More likely they'll claim a better product and charge a premium price.
Getting GRAS from the FDA is far from a sure thing. Their attempts could make the FDA take a second look at what's been going on, and maybe put a stop to the free marketing and sales of high-purity resveratrol products.

[niner]

This article was embarrassingly stupid.

Because there are so few clinical studies conducted on humans related to the ingredient, there is no golden standard for the necessary dosage levels.

However, using animal studies as a guideline, minimum levels are thought to be 30mg per person per day.

DSM recommends that its branded ingredient is used at 30-150mg per day.

It's "not yet" completely soluble in water... Are the physical properties of the molecule expected to change in the fullness of time?

I'll say one thing for them, it was remarkably prescient of them to start working on a branded resveratrol product Ten Years Ago... Was Sinclair still an undergrad then?

[Hedgehog]

This article was embarrassingly stupid.

Because there are so few clinical studies conducted on humans related to the ingredient, there is no golden standard for the necessary dosage levels.

However, using animal studies as a guideline, minimum levels are thought to be 30mg per person per day.

DSM recommends that its branded ingredient is used at 30-150mg per day.

It's "not yet" completely soluble in water... Are the physical properties of the molecule expected to change in the fullness of time?

I'll say one thing for them, it was remarkably prescient of them to start working on a branded resveratrol product Ten Years Ago... Was Sinclair still an undergrad then?

A little bird told me that a USA vendor is going to start to make synthetic resveratrol.

[maxwatt]

This article was embarrassingly stupid.

Because there are so few clinical studies conducted on humans related to the ingredient, there is no golden standard for the necessary dosage levels.

However, using animal studies as a guideline, minimum levels are thought to be 30mg per person per day.

DSM recommends that its branded ingredient is used at 30-150mg per day.

It's "not yet" completely soluble in water... Are the physical properties of the molecule expected to change in the fullness of time?

I'll say one thing for them, it was remarkably prescient of them to start working on a branded resveratrol product Ten Years Ago... Was Sinclair still an undergrad then?

A little bird told me that a USA vendor is going to start to make synthetic resveratrol.

The chemical pathways I am familiar with would be more expensive than an extract from knotweed, unless the synthetic is produced by a genetically modified yeast or bacteria. It's a bit of a stretch to call that synthetic. I'd prefer to call that unnatural.

[Anthony_Loera]

I found this section of the article particularly interesting to all of us resveratrol supplement users:

"DSM will be filing for self-affirmed GRAS (generally recognized as safe) status for Resvida. It hopes to receive this by the second quarter this year, which will open up the market for its use in foods and beverages. In fact, an initial response from Supply Expo indicated high interest from beverage manufacturers, DeJianne told NutraIngredients-USA.com.
The ingredient is not yet completely soluble in water, but DSM said it is "working on" a food formulation. However, DeJianne added that this may not be necessary, as the ingredient is stable.
DSM said it plans to accompany the launch with a comprehensive PR campaign, which it hopes will help build the brand and create consumer awareness."


So just like we confirmed: T-res is stable (stable enough for a food formulation) Also, the GRAS status should help open up a lot of markets for resveratrol products and bring down the price......

The people introducing it in this press wire are DSM Nutritional Products Ltd. Switzerland.
It's a Swiss company. It's not going to be cheap. I doubt this will bring the price down. More likely they'll claim a better product and charge a premium price.
Getting GRAS from the FDA is far from a sure thing. Their attempts could make the FDA take a second look at what's been going on, and maybe put a stop to the free marketing and sales of high-purity resveratrol products.

I hate to say it, but I completely agree with Maxwatt here.
The fact that they are marketing it as synthetic but 'nature identical', will likely raise the questions in the FDA regarding if resveratrol is acceptable at all if it comes from an herbal source.

The other issue is if "GRAS" will open up the market and bring down the price... the price of what exactly? Our favorite Indian company is still hoping for the FDA to consider their synthetic rsv. They don't want to be considered natural, and want to limit their products to the pharma industry. These folks, on the other hand want to be considered natural, in hopes to compete against herbal sources and (it appears) have some form or control over their possible patents.

They don't want to reduce pricing, they want to succeed through a patent to produce a 'natural' product.

A

[Curtis1943]

from what i have seen in the literature resveratrol on its own has limited absorption/bioavailability so would be great to know more on that front.. Unfortunately Sinclair et al used such a high amount in the rodent longevity studies to find the longevity effects. But this is not to say there is no potential there, just that in my opinion (and many others) there is not much substantiation to expect longevity effects from a recommended dose of resveratrol.

On the bioavailability note it is interesting to me that resveratrol has almost no solubility in water but it increases when ethanol is added to water http://www.cababstra...cNo=20033191761 So maybe the red wine matrix is optimal for better absorption of resveratrol. Here is where the red wine matrix may be more potent than any individual component considering alcohol (nitric oxide enhancer) plus grape OPC's plus ellagitannins from oak barrels plus a small amount of anthocyanins... I will toast to that..

[inawe]

Seems that DSM is quite a large company. They are all over the world
and manufacture different types of chemical products.
The impression I got is that they are not planning to market RSV by
itself. They want to put just a little bit in their nutritional
supplement and beverages. And they need the necessary permits for
that.
By putting a little bit of RSV in their products they'll be able to
claim life extension. Why not, everybody else is doing it.
For the small concentrations it wont make much different pricewise if
the RSV is synthetic. And they wont have to buy it from somebody else.

[sdxl]

The impression I got is that they are not planning to market RSV by
itself. They want to put just a little bit in their nutritional
supplement and beverages. And they need the necessary permits for
that.

As far as I know DSM doesn't make supplements, they are a raw material supplier.

[inawe]

The impression I got is that they are not planning to market RSV by
itself. They want to put just a little bit in their nutritional
supplement and beverages. And they need the necessary permits for
that.

As far as I know DSM doesn't make supplements, they are a raw material supplier.

I don't have anything to do with DMS but I think I know how to read:
"Micronutrient Blends offers the highest quality and safety guarantees. As the world’s only integrated vitamin and premix producer, we have eight production sites worldwide and supply Micronutrient Blends in both dry and liquid form. Our manufacturing expertise is based on GMP rules, detailed product know-how and proactive technical support. This ensures homogeneous blend formulations of consistently high quality as well as full traceability. "
More at their website
http://www.dsm.com/e...ient_blends.htm
I just wanted to point out that if you are looking to buy 1/2 kilo of 99% RSV, your best source is probably not DMS.

[Anthony_Loera]

It's possible, they may undercut the competition, to try and get their foot in the door.

That's just common sense when a new product is being introduced when the landscape already has similar ones...

A