Selegiline man, Selegiline and PEA.
LongeCityAdvocacy & Research for Unlimited Lifespans
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Cannabis for longevity?
Started by
abolitionist
, Apr 10 2008 08:31 AM
147 replies to this topic
#93
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Posted 30 April 2013 - 02:28 AM
Firstly cannabis is a neuroprotectant. The US department of health took out a patent claiming this - Alzheimer's ALS Parkinson's MS ME stroke recovery, head trauma.recovery etc etc etc http://uspatent6630507.com/ The Scripps institute states there's nothing better for Alzheimer's than THC.
Secondly, if cannabis "causes" schizophrenia we would see incidences of schizophrenia increase in a population when cannabis use increases but this has not been found. http://www.ncbi.nlm....pubmed/19560900 A population study needs no highly complex easily flawed method of separating chicken and egg. It's known that cannabis use is higher amongst the mentally ill and although there are studies claiming cause this can only be attributed to flaws in the design of the studies. At worst it might trigger schizophrenia in those whose schizophrenia would have been triggered by something else anyway.
So with the potential negatives brushed aside the good news is it's non toxic,controls inflammation, promotes homeostasis, oils the machinery of life and cures cancer really effectively.
Dennis Hill is a former MD Anderson cancer researcher of 10 years. He successfully treated a prostate cancer with a 3% survival rate using cannabis butter and RSO, a high strength cannabis oil. You can find him on youtube. He wrote a couple of summaries one on cancer treatment and one on long life and good health which I'll copy below. If the following is a bit heavy Dr Robert Melamide's lectures on youtube are excellent introductions to the area. He's chair of the biology department at UCCS so we're not talking about the sort of doctor who has a certificate from a correspondence course.
Cancer-specific Cytotoxicity of Cannabinoids
First let's look at what keeps cancer cells alive, then we will come back and examine how the cannabinoids CBD (cannabidiol) and THC (tetrahydrocannabinol) unravels cancer's aliveness.
In every cell there is a family of interconvertible sphingolipids that specifically manage the life and death of that cell. This profile of factors is called the Sphingolipid Rheostat. If ceramide (a signaling metabolite of sphingosine-1-phosphate) is high, then cell death (apoptosis) is imminent. If ceramide is low, the cell will be strong in its vitality.
Very simply, when THC connects to the CB1 or CB2 cannabinoid receptor site on the cancer cell, it causes an increase in ceramide synthesis which drives cell death. A normal healthy cell does not produce ceramide in the presence of THC, thus is not affected by the cannabinoid.
The cancer cell dies, not because of cytotoxic chemicals, but because of a tiny little shift in the mitochondria. Within most cells there is a cell nucleus, numerous mitochondria (hundreds to thousands), and various other organelles in the cytoplasm. The purpose of the mitochondria is to produce energy (ATP) for cell use. As ceramide starts to accumulate, turning up the Sphingolipid Rheostat, it increases the mitochondrial membrane pore permeability to cytochrome c, a critical protein in energy synthesis. Cytochrome c is pushed out of the mitochondria, killing the source of energy for the cell.
Ceramide also causes genotoxic stress in the cancer cell nucleus generating a protein called p53, whose job it is to disrupt calcium metabolism in the mitochondria. If this weren't enough, ceramide disrupts the cellular lysosome, the cell's digestive system that provides nutrients for all cell functions. Ceramide, and other sphingolipids, actively inhibit pro-survival pathways in the cell leaving no possibility at all of cancer cell survival.
The key to this process is the accumulation of ceramide in the system. This means taking therapeutic amounts of cannabinoid extract, steadily, over a period of time, keeping metabolic pressure on this cancer cell death pathway.
How did this pathway come to be? Why is it that the body can take a simple plant enzyme and use it for healing in many different physiological systems? is endocannabinoid system exists in all animal life, just waiting for it's matched exocannabinoid activator.
This is interesting. Our own endocannabinoid system covers all cells and nerves; it is the messenger of information flowing between our immune system and the central nervous system (CNS). It is responsible for neuroprotection, and micro-manages the immune system. is is the primary control system that maintains homeostasis; our well being.
Just out of curiosity, how does the work get done at the cellular level, and where does the body make the endocannabinoids? Here we see that endocannabinoids have their origin in nerve cells right at the synapse. When the body is compromised through illness or injury it calls insistently to the endocannabinoid system and directs the immune system to bring healing. If these homeostatic systems are weakened, it should be no surprise that exocannabinoids perform the same function. It helps the body in the most natural way possible.
To see how this works we visualize the cannabinoid as a three dimensional molecule, where one part of the molecule is configured to fit the nerve or immune cell receptor site just like a key in a lock. There are at least two types of cannabinoid receptor sites, CB1 (CNS) and CB2 (immune). In general CB1 activates the CNS messaging system, and CB2 activates the immune system, but it's much more complex than this. Both THC and anandamide activate both receptor sites. Other cannabinoids activate one or the other receptor sites. Among the strains of Cannabis, C. sativa tends toward the CB1 receptor, and C. indica tends toward CB2. So sativa is more neuroactive, and indica is more immunoactive. Another factor here is that sativa is dominated by THC cannabinoids, and indica is predominately CBD (cannabidiol).
It is known that THC and CBD are biomimetic to anandamide, that is, the body can use both interchangeably. us, when stress, injury, or illness demand more from endogenous anandamide than can be produced by the body, its mimetic exocannabinoids are activated. If the stress is transitory, then the treatment can be transitory. If the demand is sustained, such as in cancer, then treatment needs to provide sustained pressure of the modulating agent on the homeostatic systems.
Typically CBD gravitates to the densely packed CB2 receptors in the spleen, home to the body's immune system. From there, immune cells seek out and destroy cancer cells. Interestingly, it has been shown that THC and CBD cannabinoids have the ability to kill cancer cells directly without going through immune intermediaries. THC and CBD hijack the lipoxygenase pathway to directly inhibit tumor growth. As a side note, it has been discovered that CBD inhibits anandamide reuptake. Here we see that cannabidiol helps the body preserve its own natural endocannabinoid by inhibiting the enzyme that breaks down anandamide.
This brief survey touches lightly on a few essential concepts. Mostly I would like to leave you with an appreciation that nature has designed the perfect medicine that fits exactly with our own immune system of receptors and signaling metabolites to provide rapid and complete immune response for systemic integrity and metabolic homeostasis.
~Dennis Hill
The Human Endocannabinoid System Meets the Infammatory Cytokine Cascade
The Endocannabinoid System (ECS) started revealing itself to researchers in the 1940s and by the late ‘60s the basic structure and functionality had been laid out. Today we know the ECS is a comprehensive system of biochemical modulators that maintain homeostasis in all body systems including the central and peripheral nervous systems, all organ systems, somatic tissues, and all metabolic biochemical systems, including the immune system.
This homeostatic matrix is not a recent evolutionary twist just for humans; we find the Endo-cannabinoid System in every chordate creature for the last 500 million years. It is a fully mature biochemical technology that has maintained health and metabolic balance for most of the history of life itself.
The two major interactive systems within the ECS are (1) the cannabinoid receptors that we find on all cell surfaces and neurological junctions and (2) the endocannabinoids that fit the receptors to trigger various metabolic processes. Looking at a cannabinoid receptor distribution map we see that CB1 receptors, that are most sensitive to anandamide, are found in the brain, spinal nerves, and peripheral nerves. CB2 receptors preferred by 2-arachidonoylglycerol (2-AG) are found largely in the immune system, primarily the spleen. A mix of CB1 and CB2 receptors are found throughout the rest of the body including the skeletal system. And yes, 2-AG or CBDwill grow new trabecular bone.1 It is also useful to note that both anandamide and 2-AG can activate either CB1 or CB2 receptors.
The nature of the endocannabinoids are functionally much like neurotransmitters, but structurally are eicosanoids in the family of signaling sphingolipids. These signaling cannabinoids keep track of metabolic systems all over the body. This information is shared with the nervous system and the immune system so that any imbalance is attended to. If the body is in chronic disease or emotional stress, the immune system can fall behind and lose control of compromised systems. It is here that phytocannabinoids can pitch in to support the stressed body in a return to health. The cannabis plant provides analogues of the body’s primary signaling cannabinoids. Tetrahydrocannabinol (THC) is mimetic to anandamide, and cannabidiol (CBD) is mimetic to 2-AG, and has the same affinity to CB1 and CB2 receptors; providing the body with additional support for the immune and endocannabinoid systems.
Phytocannabinoids supercharge the body’s own Endocannabinoid System by amping up the response to demand from the immune signaling system in two modes of intervention: one, of course, is in bonding with the cannabinoid receptors; the other is in regulation of innumerable physiological processes, such as cannabinoid’s powerful neuroprotective and anti-in$ammatory actions, quite apart from the receptor system. It is interesting to note here that the phytocannabinoids and related endocannabinoids are functionally similar, but structurally different. As noted above, anandamide and 2-AG are eicosanoids while THC and CBD are tricyclic terpenes.
Let us look more closely at the two primary therapeutic cannabinoids, THC and CBD. The National Institutes of Health tell us that THC is the best known because of its signature psycho-tropic effect. is government report shows THC to be effective as an anti-cancer treatment, an appetite stimulant, analgesic, antiemetic, anxiolytic, and sedative.2
CBD (cannabidiol) is a metabolic sibling of THC, in that they are alike in many ways but are also different in important properties. First we see that CBD has no psychotropic effects and there are few CB2 receptors in the brain and peripheral nerves. There appears to be a broader therapeutic profile associated with CBD, which is listed here: anxiolytic, anticancer, antipsychotic, antidiabetic, antiepileptic, antisporiatic, neuroprotective, intestinal anti-prokinetic, vasorelaxant, analgesic, antispasmodic, bone-stimulant, anti-ishcemic, anti-inflammatory, antiproliferative, immunosupressive, antiemetic, antibacterial.
One of the most important health benefits of cannabinoids is their anti-inflammatory property. In this, they are strong modulators of the inflammatory cytokine cascade. Numerous disease states arise out of chronic inflammation; such as, depression, dementias including Alzheimer’s, cancer, arthritis and other autoimmune disorders, viral infection, HIV, brain injury, etc.
Inflammatory cytokines can be activated by oxidative stress and disease states. Cannabinoids, being immunomodulators interrupt the cytokine inflammatory cascade so that local inflammation does not result in tissue pathology. Thus we are spared morbid or terminal illnesses.4
If our own endocannabinoid system can maintain metabolic homeostasis and even cure serious disease, why are we plagued by illness? We know that the body produces only small amounts of anandamide and 2-AG; enough to maintain the body but not enough to overcome chronic stress, illness, injury, or malnutrition. Cannabis is the only plant we know of that produces phyto-cannabinoids that mimic our own endocannabinoids. One of the great benefits of this mimetic medicine is that cannabinoids are essentially natural to our biology and do no harm to our tissues and systems.
It is well known that most diseases of aging are inflammatory in origin, thus making cannabis the best anti-aging supplement we could take to avoid arthritis, dementia, hypertension, diabetes, osteoporosis, and cancer. is is our key to good health and long life.
Since it is such an important attribute, as well as being independent of the cannabinoid recep-tor system, let’s look a little deeper into the ability of cannabinoids to inhibit the inflammatory cytokine cascade. Inflammation is good for us, a little here, a little there; it brings T-cells and macrophages to infection sites. is is good. However, chronic inflammation can cause serious illness and death. How do phytocannabinoids rescue us from dreaded infirmities? When the call comes in to the immune system to send troops, the first thing to happen is that the immune system signals glial cells to produce cytokines. Once this cat is out of the bag, the process can go one of two ways.
A) Killer cells clean up the infection and all is well.
Cytokines can stimulate more cytokine production and cause many more cytokine receptors to awaken. Unchecked, this becomes a cytokine storm showing symptoms of swelling, redness, fatigue, and nausea; even death.
Phytocannabinoids have the ability to suppress this inflammatory cytokine cascade by inhibiting glial cell production of the cytokines interferon or interleukin. Here we see the seeds of chronic inflammation dissolved by the modulation process of cannabinoids bringing homeostasis to systems out of balance. This is a good example of how cannabinoids normalize biological processes all throughout the body and allows us to keep that glow of well-being through a long and happy lifetime.
~Dennis Hill
Secondly, if cannabis "causes" schizophrenia we would see incidences of schizophrenia increase in a population when cannabis use increases but this has not been found. http://www.ncbi.nlm....pubmed/19560900 A population study needs no highly complex easily flawed method of separating chicken and egg. It's known that cannabis use is higher amongst the mentally ill and although there are studies claiming cause this can only be attributed to flaws in the design of the studies. At worst it might trigger schizophrenia in those whose schizophrenia would have been triggered by something else anyway.
So with the potential negatives brushed aside the good news is it's non toxic,controls inflammation, promotes homeostasis, oils the machinery of life and cures cancer really effectively.
Dennis Hill is a former MD Anderson cancer researcher of 10 years. He successfully treated a prostate cancer with a 3% survival rate using cannabis butter and RSO, a high strength cannabis oil. You can find him on youtube. He wrote a couple of summaries one on cancer treatment and one on long life and good health which I'll copy below. If the following is a bit heavy Dr Robert Melamide's lectures on youtube are excellent introductions to the area. He's chair of the biology department at UCCS so we're not talking about the sort of doctor who has a certificate from a correspondence course.
Cancer-specific Cytotoxicity of Cannabinoids
First let's look at what keeps cancer cells alive, then we will come back and examine how the cannabinoids CBD (cannabidiol) and THC (tetrahydrocannabinol) unravels cancer's aliveness.
In every cell there is a family of interconvertible sphingolipids that specifically manage the life and death of that cell. This profile of factors is called the Sphingolipid Rheostat. If ceramide (a signaling metabolite of sphingosine-1-phosphate) is high, then cell death (apoptosis) is imminent. If ceramide is low, the cell will be strong in its vitality.
Very simply, when THC connects to the CB1 or CB2 cannabinoid receptor site on the cancer cell, it causes an increase in ceramide synthesis which drives cell death. A normal healthy cell does not produce ceramide in the presence of THC, thus is not affected by the cannabinoid.
The cancer cell dies, not because of cytotoxic chemicals, but because of a tiny little shift in the mitochondria. Within most cells there is a cell nucleus, numerous mitochondria (hundreds to thousands), and various other organelles in the cytoplasm. The purpose of the mitochondria is to produce energy (ATP) for cell use. As ceramide starts to accumulate, turning up the Sphingolipid Rheostat, it increases the mitochondrial membrane pore permeability to cytochrome c, a critical protein in energy synthesis. Cytochrome c is pushed out of the mitochondria, killing the source of energy for the cell.
Ceramide also causes genotoxic stress in the cancer cell nucleus generating a protein called p53, whose job it is to disrupt calcium metabolism in the mitochondria. If this weren't enough, ceramide disrupts the cellular lysosome, the cell's digestive system that provides nutrients for all cell functions. Ceramide, and other sphingolipids, actively inhibit pro-survival pathways in the cell leaving no possibility at all of cancer cell survival.
The key to this process is the accumulation of ceramide in the system. This means taking therapeutic amounts of cannabinoid extract, steadily, over a period of time, keeping metabolic pressure on this cancer cell death pathway.
How did this pathway come to be? Why is it that the body can take a simple plant enzyme and use it for healing in many different physiological systems? is endocannabinoid system exists in all animal life, just waiting for it's matched exocannabinoid activator.
This is interesting. Our own endocannabinoid system covers all cells and nerves; it is the messenger of information flowing between our immune system and the central nervous system (CNS). It is responsible for neuroprotection, and micro-manages the immune system. is is the primary control system that maintains homeostasis; our well being.
Just out of curiosity, how does the work get done at the cellular level, and where does the body make the endocannabinoids? Here we see that endocannabinoids have their origin in nerve cells right at the synapse. When the body is compromised through illness or injury it calls insistently to the endocannabinoid system and directs the immune system to bring healing. If these homeostatic systems are weakened, it should be no surprise that exocannabinoids perform the same function. It helps the body in the most natural way possible.
To see how this works we visualize the cannabinoid as a three dimensional molecule, where one part of the molecule is configured to fit the nerve or immune cell receptor site just like a key in a lock. There are at least two types of cannabinoid receptor sites, CB1 (CNS) and CB2 (immune). In general CB1 activates the CNS messaging system, and CB2 activates the immune system, but it's much more complex than this. Both THC and anandamide activate both receptor sites. Other cannabinoids activate one or the other receptor sites. Among the strains of Cannabis, C. sativa tends toward the CB1 receptor, and C. indica tends toward CB2. So sativa is more neuroactive, and indica is more immunoactive. Another factor here is that sativa is dominated by THC cannabinoids, and indica is predominately CBD (cannabidiol).
It is known that THC and CBD are biomimetic to anandamide, that is, the body can use both interchangeably. us, when stress, injury, or illness demand more from endogenous anandamide than can be produced by the body, its mimetic exocannabinoids are activated. If the stress is transitory, then the treatment can be transitory. If the demand is sustained, such as in cancer, then treatment needs to provide sustained pressure of the modulating agent on the homeostatic systems.
Typically CBD gravitates to the densely packed CB2 receptors in the spleen, home to the body's immune system. From there, immune cells seek out and destroy cancer cells. Interestingly, it has been shown that THC and CBD cannabinoids have the ability to kill cancer cells directly without going through immune intermediaries. THC and CBD hijack the lipoxygenase pathway to directly inhibit tumor growth. As a side note, it has been discovered that CBD inhibits anandamide reuptake. Here we see that cannabidiol helps the body preserve its own natural endocannabinoid by inhibiting the enzyme that breaks down anandamide.
This brief survey touches lightly on a few essential concepts. Mostly I would like to leave you with an appreciation that nature has designed the perfect medicine that fits exactly with our own immune system of receptors and signaling metabolites to provide rapid and complete immune response for systemic integrity and metabolic homeostasis.
~Dennis Hill
The Human Endocannabinoid System Meets the Infammatory Cytokine Cascade
The Endocannabinoid System (ECS) started revealing itself to researchers in the 1940s and by the late ‘60s the basic structure and functionality had been laid out. Today we know the ECS is a comprehensive system of biochemical modulators that maintain homeostasis in all body systems including the central and peripheral nervous systems, all organ systems, somatic tissues, and all metabolic biochemical systems, including the immune system.
This homeostatic matrix is not a recent evolutionary twist just for humans; we find the Endo-cannabinoid System in every chordate creature for the last 500 million years. It is a fully mature biochemical technology that has maintained health and metabolic balance for most of the history of life itself.
The two major interactive systems within the ECS are (1) the cannabinoid receptors that we find on all cell surfaces and neurological junctions and (2) the endocannabinoids that fit the receptors to trigger various metabolic processes. Looking at a cannabinoid receptor distribution map we see that CB1 receptors, that are most sensitive to anandamide, are found in the brain, spinal nerves, and peripheral nerves. CB2 receptors preferred by 2-arachidonoylglycerol (2-AG) are found largely in the immune system, primarily the spleen. A mix of CB1 and CB2 receptors are found throughout the rest of the body including the skeletal system. And yes, 2-AG or CBDwill grow new trabecular bone.1 It is also useful to note that both anandamide and 2-AG can activate either CB1 or CB2 receptors.
The nature of the endocannabinoids are functionally much like neurotransmitters, but structurally are eicosanoids in the family of signaling sphingolipids. These signaling cannabinoids keep track of metabolic systems all over the body. This information is shared with the nervous system and the immune system so that any imbalance is attended to. If the body is in chronic disease or emotional stress, the immune system can fall behind and lose control of compromised systems. It is here that phytocannabinoids can pitch in to support the stressed body in a return to health. The cannabis plant provides analogues of the body’s primary signaling cannabinoids. Tetrahydrocannabinol (THC) is mimetic to anandamide, and cannabidiol (CBD) is mimetic to 2-AG, and has the same affinity to CB1 and CB2 receptors; providing the body with additional support for the immune and endocannabinoid systems.
Phytocannabinoids supercharge the body’s own Endocannabinoid System by amping up the response to demand from the immune signaling system in two modes of intervention: one, of course, is in bonding with the cannabinoid receptors; the other is in regulation of innumerable physiological processes, such as cannabinoid’s powerful neuroprotective and anti-in$ammatory actions, quite apart from the receptor system. It is interesting to note here that the phytocannabinoids and related endocannabinoids are functionally similar, but structurally different. As noted above, anandamide and 2-AG are eicosanoids while THC and CBD are tricyclic terpenes.
Let us look more closely at the two primary therapeutic cannabinoids, THC and CBD. The National Institutes of Health tell us that THC is the best known because of its signature psycho-tropic effect. is government report shows THC to be effective as an anti-cancer treatment, an appetite stimulant, analgesic, antiemetic, anxiolytic, and sedative.2
CBD (cannabidiol) is a metabolic sibling of THC, in that they are alike in many ways but are also different in important properties. First we see that CBD has no psychotropic effects and there are few CB2 receptors in the brain and peripheral nerves. There appears to be a broader therapeutic profile associated with CBD, which is listed here: anxiolytic, anticancer, antipsychotic, antidiabetic, antiepileptic, antisporiatic, neuroprotective, intestinal anti-prokinetic, vasorelaxant, analgesic, antispasmodic, bone-stimulant, anti-ishcemic, anti-inflammatory, antiproliferative, immunosupressive, antiemetic, antibacterial.
One of the most important health benefits of cannabinoids is their anti-inflammatory property. In this, they are strong modulators of the inflammatory cytokine cascade. Numerous disease states arise out of chronic inflammation; such as, depression, dementias including Alzheimer’s, cancer, arthritis and other autoimmune disorders, viral infection, HIV, brain injury, etc.
Inflammatory cytokines can be activated by oxidative stress and disease states. Cannabinoids, being immunomodulators interrupt the cytokine inflammatory cascade so that local inflammation does not result in tissue pathology. Thus we are spared morbid or terminal illnesses.4
If our own endocannabinoid system can maintain metabolic homeostasis and even cure serious disease, why are we plagued by illness? We know that the body produces only small amounts of anandamide and 2-AG; enough to maintain the body but not enough to overcome chronic stress, illness, injury, or malnutrition. Cannabis is the only plant we know of that produces phyto-cannabinoids that mimic our own endocannabinoids. One of the great benefits of this mimetic medicine is that cannabinoids are essentially natural to our biology and do no harm to our tissues and systems.
It is well known that most diseases of aging are inflammatory in origin, thus making cannabis the best anti-aging supplement we could take to avoid arthritis, dementia, hypertension, diabetes, osteoporosis, and cancer. is is our key to good health and long life.
Since it is such an important attribute, as well as being independent of the cannabinoid recep-tor system, let’s look a little deeper into the ability of cannabinoids to inhibit the inflammatory cytokine cascade. Inflammation is good for us, a little here, a little there; it brings T-cells and macrophages to infection sites. is is good. However, chronic inflammation can cause serious illness and death. How do phytocannabinoids rescue us from dreaded infirmities? When the call comes in to the immune system to send troops, the first thing to happen is that the immune system signals glial cells to produce cytokines. Once this cat is out of the bag, the process can go one of two ways.
A) Killer cells clean up the infection and all is well.
Cytokines can stimulate more cytokine production and cause many more cytokine receptors to awaken. Unchecked, this becomes a cytokine storm showing symptoms of swelling, redness, fatigue, and nausea; even death.
Phytocannabinoids have the ability to suppress this inflammatory cytokine cascade by inhibiting glial cell production of the cytokines interferon or interleukin. Here we see the seeds of chronic inflammation dissolved by the modulation process of cannabinoids bringing homeostasis to systems out of balance. This is a good example of how cannabinoids normalize biological processes all throughout the body and allows us to keep that glow of well-being through a long and happy lifetime.
~Dennis Hill
#94
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Posted 30 April 2013 - 08:13 AM
I know the cancer thing is a big claim so here are 625 peer reviewed articles - http://www.uccs.edu/rmelamed/cannabinoids-and-cancer.html as for the main point about cognitive enhancement as well as being a powerful neuroprotectant and perhaps promoting neurogenesis it induces synaptic plasticity which allows users to accept new ideas, learn new skills or to rewire the brain after trauma. This is the reason it effects short term memory and the reason it's effective for PTSD. Because of the way memories are encoded and stored, memory recall is effectively an on-the-fly reconstruction of elements scattered throughout various areas of our brains. Memories are not stored in our brains like books on library shelves, or even as a collection of self-contained recordings or pictures or video clips, but may be better thought of as a kind of collage or a jigsaw puzzle, involving different elements stored in disparate parts of the brain linked together by associations and neural networks. Memory retrieval therefore requires re-visiting the nerve pathways the brain formed when encoding the memory, and the strength of those pathways determines how quickly the memory can be recalled. Recall effectively returns a memory from long-term storage to short-term or working memory, where it can be accessed, in a kind of mirror image of the encoding process. It is then re-stored back in long-term memory, thus re-consolidating and strengthening it. Re-remembering into a "plastic" mind (that's also benefiting from the anti-depressant effects) the THC user can "re-frame" the traumatic events before re-remembering the re-framed memory in a less emotionally powerful form. The re-consolidation does not take place and the previously laid down pathways are weakened.
#95
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Posted 30 April 2013 - 08:19 AM
Sorry just realised the main point wasn't cognitive enhancement. Anyway here's the best 2 1/2 hours of information I can offer Dr Melamide - http://www.youtube.c...0x_e_6M#t=1674s
#96
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Posted 30 April 2013 - 08:30 AM
and here are several thousand studies on cannabinoids - http://www.letfreedo...listjan2012.pdf
#98
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Posted 30 April 2013 - 09:26 AM
Both my grandfather and great grandfather suffered from Parkinson's so this is bitter sweet for me. Had I believed less in the medical system when my grandfather pleaded with me, his "clever boy" to find a way to help him the last 15 years of his life could have been very different. I cared for him during his last 3. Nice to know I have options if I suffer the same fate though.
Alzheimers's
"While we are certainly not advocating the use of illegal drugs, these findings offer convincing evidence that THC possesses remarkable inhibitory qualities, especially when compared to AChE inhibitors currently available to patients,"
http://www.scripps.e...006/080906.html
Pulmonary Fibrosis
http://www.youtube.c...c&feature=share
Alzheimers's
"While we are certainly not advocating the use of illegal drugs, these findings offer convincing evidence that THC possesses remarkable inhibitory qualities, especially when compared to AChE inhibitors currently available to patients,"
http://www.scripps.e...006/080906.html
Pulmonary Fibrosis
http://www.youtube.c...c&feature=share
Edited by DomLP, 30 April 2013 - 09:30 AM.
#99
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Posted 30 April 2013 - 09:38 AM
This is an excellent testimonial - http://www.youtube.com/watch?v=mXvHatrFNGw
This documentary would have been called "Cannabis Cures Cancer" would that not have landed the makers in jail so here is "What if Cannabis Cured Cancer" http://www.youtube.c...h?v=1bMt83_IWkE
This documentary "Medical Cannabis and it's impact on human health" is tentative in it's claims but also worth a watch - http://www.youtube.com/watch?v=8Md2WNqqxTQ
This documentary would have been called "Cannabis Cures Cancer" would that not have landed the makers in jail so here is "What if Cannabis Cured Cancer" http://www.youtube.c...h?v=1bMt83_IWkE
This documentary "Medical Cannabis and it's impact on human health" is tentative in it's claims but also worth a watch - http://www.youtube.com/watch?v=8Md2WNqqxTQ
Edited by DomLP, 30 April 2013 - 09:40 AM.
#100
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Posted 30 April 2013 - 09:50 AM
Although we don't find out if the four shirinking tumours of the original twelve do continue to shrink and disappear like the others this is still a great testimony -
Here's Dennis the former MD Anderson cancer researching biochemist telling his story. First to Ava Marie a sweet but slightly irritating interviewer.
http://www.youtube.c...h?v=G_7gy7Dyta0
and then on Cannabis Nation Radio archive Friday, April 27, 2012
http://www.latalkrad...om/Cannabis.php
This is the first film many people see on the subject. It's about Rick Simpson the man who's re-discovered the cannabis' full healing properties.
http://www.youtube.c...h?v=0psJhQHk_GI
Here's Rick's cancer specific seminar
http://www.youtube.c...ture=plpp_video
Here's a long lecture in which Rick says all the things he has seen the oil work for.
http://www.youtube.c...h?v=nJi-_eqqubk
Here's Dennis the former MD Anderson cancer researching biochemist telling his story. First to Ava Marie a sweet but slightly irritating interviewer.
http://www.youtube.c...h?v=G_7gy7Dyta0
and then on Cannabis Nation Radio archive Friday, April 27, 2012
http://www.latalkrad...om/Cannabis.php
This is the first film many people see on the subject. It's about Rick Simpson the man who's re-discovered the cannabis' full healing properties.
http://www.youtube.c...h?v=0psJhQHk_GI
Here's Rick's cancer specific seminar
http://www.youtube.c...ture=plpp_video
Here's a long lecture in which Rick says all the things he has seen the oil work for.
http://www.youtube.c...h?v=nJi-_eqqubk
Edited by DomLP, 30 April 2013 - 09:55 AM.
#101
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Posted 30 April 2013 - 10:05 AM
I haven't used or made Rick Simpson Oil myself but in terms of personal experience I can say that it worked for the first person I told about it. He had terminal kidney and lung cancer and was about to have his second kidney removed. A few months later he contacted me to say he was completely cancer free. Through facebook I'm now "friends" with dozens of people who have successfully used it on themselves or made it for patients, friends and loved ones.... and some of them have successfully treated dozens of people. For instance I asked someone I recently friended what successes he had and this was his reply
"Well I lost count of how many people over the past 8 yrs but I've destroyed pancreatic, eye, kidney, colon, DIPG brain, lung, skin, testicle and a few other small cancers and countless MS, Diabetes, PTSD conditions. I see you mentioned MS I just helped a lady last month who had severe MS for 10 yrs brain lesions, drop foot, bedridden ..... She now runs everyday, walked the highest part of the tight rope at splash lagoon (theme park) last weekend, has no more pain whatsoever and is completely off all her medication.... Including her morphine patches. She has her life back and she saw amazing results within 12 hrs. She got right up out of bed after being bed ridden for 3 days its truly a miracle and this has basically happened to every MS person I've met. 3 within the last 2 months and their doctors are blown away they lost weight and the lesions are almost gone."
and he is one of many. I haven't actively friended everyone I know has successfully used this oil. If I were to actively seek them out through the various forums their numbers would be into the hundreds. Here is a link to nearly 200 testimonies on the Rick Simpson fb page - https://www.facebook...23502987&type=3
"Well I lost count of how many people over the past 8 yrs but I've destroyed pancreatic, eye, kidney, colon, DIPG brain, lung, skin, testicle and a few other small cancers and countless MS, Diabetes, PTSD conditions. I see you mentioned MS I just helped a lady last month who had severe MS for 10 yrs brain lesions, drop foot, bedridden ..... She now runs everyday, walked the highest part of the tight rope at splash lagoon (theme park) last weekend, has no more pain whatsoever and is completely off all her medication.... Including her morphine patches. She has her life back and she saw amazing results within 12 hrs. She got right up out of bed after being bed ridden for 3 days its truly a miracle and this has basically happened to every MS person I've met. 3 within the last 2 months and their doctors are blown away they lost weight and the lesions are almost gone."
and he is one of many. I haven't actively friended everyone I know has successfully used this oil. If I were to actively seek them out through the various forums their numbers would be into the hundreds. Here is a link to nearly 200 testimonies on the Rick Simpson fb page - https://www.facebook...23502987&type=3
Edited by DomLP, 30 April 2013 - 10:14 AM.
#102
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Posted 12 May 2013 - 06:39 PM
I can say this much, started smoking when 16, started strong about half 8th a day, worked my way up to almost 7g sometimes 14 g per day, had dopamine downregulation (i know that now, wasnt sure what kind of withdrawals i was going through)
quit cold turkey about 3.5 months ago. smoked 3 times in last 3 weeks, about once a week now that im not dependent and just curious
I was completely paranoid the first time back, in a way ive never experienced. last night however was one of the happiest and best times ive ever had, even stupid and usually annoying conversations didnt bother me, and sex was incredible, great feeling and last for hours just like when i was heavily vaping cannabis but even better control and sensation..
what is a scientific cause and explanation for this?
i wish there was a mix of the great feeling but not so relaxing and demotivating, otherwise id keep going
Oh btw, im in california and SB420 so legal issues are null
quit cold turkey about 3.5 months ago. smoked 3 times in last 3 weeks, about once a week now that im not dependent and just curious
I was completely paranoid the first time back, in a way ive never experienced. last night however was one of the happiest and best times ive ever had, even stupid and usually annoying conversations didnt bother me, and sex was incredible, great feeling and last for hours just like when i was heavily vaping cannabis but even better control and sensation..
what is a scientific cause and explanation for this?
i wish there was a mix of the great feeling but not so relaxing and demotivating, otherwise id keep going
Oh btw, im in california and SB420 so legal issues are null
#103
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Posted 18 July 2013 - 03:51 AM
When looking over the research, I think it's good idea to focus on studies that utilize whole cannabis and not synthesized or purified THC.
One should also look for studies that use cannabis in the best ways : vaporization and oral consumption. Obviously, smoking is a bad idea.
One should also look for studies that use cannabis in the best ways : vaporization and oral consumption. Obviously, smoking is a bad idea.
#104
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Posted 19 July 2013 - 03:23 AM
I have been daily pot smoking for the last 2 weeks now after smoking only a couple of times in the last several years.
Still get a little paranoid but the pot does give me a different perspective on things, I find myself waiting for everyone to clear out of the office now so I can punch a few cones haha. It would be easy for me to get back to being a stoner.
Still get a little paranoid but the pot does give me a different perspective on things, I find myself waiting for everyone to clear out of the office now so I can punch a few cones haha. It would be easy for me to get back to being a stoner.
#105
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Posted 27 July 2013 - 05:22 PM
http://tokesignals.c...aging-of-brain/
"Worth Repeating: Cannabis May Help Combat Aging of the Brain"
"Worth Repeating: Cannabis May Help Combat Aging of the Brain"
Edited by abolitionist, 27 July 2013 - 05:27 PM.
#106
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Posted 29 June 2014 - 03:36 AM
Our government must suspect Cannabis is really good for something since they took out a patent on it.
http://www.medicalma...nabinoid-patent
http://patft.uspto.g...7&RS=PN/6630507
http://nevergetbuste...patent-6630507/
It's mentioned in this documentary too
#108
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Posted 04 September 2014 - 01:56 PM
I've been thinking about this topic a lot lately. There must be someway to force the government to do serious longevity studies on Cannabis in monkeys, rats, mice, etc., like they did for calorie restriction and intermittent fasting. Cannabis would probably enhance calorie restriction and fasting - particularly the high CBD, low THC strain that's so popular as of late. See Project CBD, at http://www.projectcbd.org/. Possibly the people could directly vote for the research the same as they've done for medical marijuana. I think it's something like 75 to 90 percent of the American public support medical marijuana. May be someone could beat Dr. Andrzej Bartke for the Methuselah Mouse Prize.
#109
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Posted 12 September 2014 - 05:05 PM
The jail time involved when the cops bust you is highly likely to have a negative effect on total lifespan.
Hahaha lol america, and also the uk as extreme police states, im terrified of the devastating effects of sending ppl to prison for minor offences as its a learning school for criminality, ive been in prison 3 times, arrested 4 times, here you go to jail for 6 moths for robbing a bank the first time and suprise it works.
Extreme police states like the us dont reduce crime.
I take a few puffs of synthetic cannabinoids with tobacco a few times a day, its pleasant and with my stack i feel therapeutic effects but no negatives, also pleasant effects.
#110
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Posted 13 September 2014 - 05:41 AM
Jamaica has a lower than average life expectancy for the Carribean, and lower than the US.
http://www.infopleas...cy-country.html
I don't think marijuana is healthy. It is addictive for people now, too. Yes, it's worse to smoke but it's still bad for you to take other ways.
Edited by Luminosity, 13 September 2014 - 05:43 AM.
#111
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Posted 13 September 2014 - 11:24 AM
I don't think marijuana is healthy. It is addictive for people now, too. Yes, it's worse to smoke but it's still bad for you to take other ways.
Yeah, and cigarettes are far, far worse, yet legal. And the problem with smoking pot is that most who smoke it also smoke cigarettes. But when you tease the two apart and examine them separately, you find that pot is neutral when it comes to things like cancer, and cigarettes are a scourge.
To investigate the association between cannabis smoking and lung cancer risk, data on 2,159 lung cancer cases and 2,985 controls were pooled from 6 case-control studies in the US, Canada, UK, and New Zealand within the International Lung Cancer Consortium. Study-specific associations between cannabis smoking and lung cancer were estimated using unconditional logistic regression adjusting for sociodemographic factors, tobacco smoking status and pack-years; odds-ratio estimates were pooled using random effects models. Subgroup analyses were done for sex, histology and tobacco smoking status. The shapes of dose-response associations were examined using restricted cubic spline regression. The overall pooled OR for habitual versus nonhabitual or never users was 0.96 (95% CI: 0.66-1.38). Compared to nonhabitual or never users, the summary OR was 0.88 (95%CI: 0.63-1.24) for individuals who smoked 1 or more joint-equivalents of cannabis per day and 0.94 (95%CI: 0.67-1.32) for those consumed at least 10 joint-years. For adenocarcinoma cases the ORs were 1.73 (95%CI: 0.75-4.00) and 1.74 (95%CI: 0.85-3.55), respectively. However, no association was found for the squamous cell carcinoma based on small numbers. Weak associations between cannabis smoking and lung cancer were observed in never tobacco smokers. Spline modeling indicated a weak positive monotonic association between cumulative cannabis use and lung cancer, but precision was low at high exposure levels. Results from our pooled analyses provide little evidence for an increased risk of lung cancer among habitual or long-term cannabis smokers, although the possibility of potential adverse effect for heavy consumption cannot be excluded.
So it appears that the major risk factors are the FDA and the US government. This is a political problem, not a medical one. The US government is locking up people at a rate only equaled by Stalin's Russia with the pretense that this is being done for the good of society, when the reality is that this seemingly mad drug war was born at the end of segregation as a cover for a new Jim Crow where blacks and other minorities are locked up at a rate far higher than whites for the same rate of illegal behavior. And our government has spread the disaster of prohibition over much of the world, nearly destroying many countries south of the border in the process by creating an enormous black market in which illegal and highly violent cartels can flourish.
Edited by Turnbuckle, 13 September 2014 - 11:36 AM.
#112
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Posted 16 September 2014 - 05:44 AM
The ideology is running the argument. I don't accept that most people who smoke pot smoke cigarettes. I've seen a close relative get severe bronchitis from smoking pot addictively, get a mood disorder, drop out of school and do nothing all day, then go on to become a cocaine addict. Many people where I live use pot and I see that it is destructive. Taking hot resinous smoke into your lungs hurts them. Many people's moods, temperaments, memories, drive and concentration are hurt by smoking a lot of pot. As for what else it causes, I guess we will find out as the baby boom ages. We really don't know.
#113
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Posted 16 September 2014 - 12:56 PM
Taking hot resinous smoke into your lungs hurts them. Many people's moods, temperaments, memories, drive and concentration are hurt by smoking a lot of pot. As for what else it causes, I guess we will find out as the baby boom ages. We really don't know.
You apparently think this is a new drug. It isn't. It's ancient. Documentation of its medical uses goes back five thousand years and its use as an intoxicant goes back much further. So we don't have to wait for the baby boom to age. In fact, if you want to argue how dangerous it is to the country, just point out that our last three presidents were pot smokers. So if nothing else, it can turn you into a raving hypocrite.
#114
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Posted 16 September 2014 - 04:00 PM
The ideology is running the argument. I don't accept that most people who smoke pot smoke cigarettes. I've seen a close relative get severe bronchitis from smoking pot addictively, get a mood disorder, drop out of school and do nothing all day, then go on to become a cocaine addict. Many people where I live use pot and I see that it is destructive. Taking hot resinous smoke into your lungs hurts them. Many people's moods, temperaments, memories, drive and concentration are hurt by smoking a lot of pot. As for what else it causes, I guess we will find out as the baby boom ages. We really don't know.
The key here is the smoking of marijuana addictively. Most addictive personalities suffered serious trauma in their lives and self-medicate for this reason. Your close relative probably had an addictive personality. Most people who smoke marijuana or try other drugs do not become hardcore addicts the statistics show. Below is a video where the speaker explains the process of addiction.
I think the best marijuana out there is the stuff that doesn't get you high. It's high in CBD and low in THC. I think this stuff would be better for the addictive personality types who need good medicine, but are at risk to becoming addicted to pharmaceuticals that have very negative side effects. This stuff should not be smoked, but instead taken in oral form as an oil, an edible or juiced as some are doing. http://greendrinksfo...uicing Cannabis.
#115
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Posted 16 September 2014 - 04:08 PM
The ideology is running the argument. I don't accept that most people who smoke pot smoke cigarettes. I've seen a close relative get severe bronchitis from smoking pot addictively, get a mood disorder, drop out of school and do nothing all day, then go on to become a cocaine addict. Many people where I live use pot and I see that it is destructive. Taking hot resinous smoke into your lungs hurts them. Many people's moods, temperaments, memories, drive and concentration are hurt by smoking a lot of pot. As for what else it causes, I guess we will find out as the baby boom ages. We really don't know.
The key here is the smoking of marijuana addictively. Most addictive personalities suffered serious trauma in their lives and self-medicate for this reason. Your close relative probably had an addictive personality. Most people who smoke marijuana or try other drugs do not become hardcore addicts the statistics show. Watch this You Tube video, Ending The War on Drugs - With Compassion!, where the speaker explains the process of addiction.
I think the best marijuana out there is the stuff that doesn't get you high. It's high in CBD and low in THC. I think this stuff would be better for the addictive personality types who need good medicine, but are at risk to becoming addicted to pharmaceuticals that have very negative side effects. This stuff should not be smoked, but instead taken orally as an oil, an edible, or juiced as some are doing. http://greendrinksfo...uicing Cannabis.
#116
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Posted 19 September 2014 - 10:06 PM
I think the best marijuana out there is the stuff that doesn't get you high. It's high in CBD and low in THC. I think this stuff would be better for the addictive personality types who need good medicine, but are at risk to becoming addicted to pharmaceuticals that have very negative side effects. This stuff should not be smoked, but instead taken orally as an oil, an edible, or juiced as some are doing. http://greendrinksfo...uicing Cannabis.
Most of the research I've seen indicates that the THC ingredient may be harmful while CBD and a few other compounds like CBN have different beneficial health effects, perhaps counteracting THC toxicity. But I'm not sure much research has been done on finding efficient ways to separate out and isolate the different compounds. Fwiw, they do have slightly different boiling points (THC: 157 degrees C; CBD: 160 degrees C). There are a few growers in Colorado experimenting with selective breeding to develop high CBD marijuana strains but I understand that so far the best they have is a strain which yields a 25% probability (1 in every 4 seedlings) of a high CBD plant. But they need to test each individual plant to make the proper selection. Bluebird Botanicals sells CBD oil but its looks like its a pretty low a concentration (250 mg CBD per ounce). I see they also have an atomizer product which might be better being 4x more potent:
http://www.bluebird-..._Vaporizers.php
Burning any kind of oil generates both toxic and carcinogenic products that you wouldn't want to inhale. Or even eat. Lower temperature vaporization might be a better approach. But I'm a little suspicious of the Propylene Glycol, which I think is the same vehicle used in most electronic nicotine cigarettes. Wax extraction might be better, increasing CBD concentration while leaving the Propylene Glycol out.
Howard
#117
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Posted 19 September 2014 - 11:43 PM
Most of the research I've seen indicates that the THC ingredient may be harmful while CBD and a few other compounds like CBN have different beneficial health effects, perhaps counteracting THC toxicity. But I'm not sure much research has been done on finding efficient ways to separate out and isolate the different compounds. Fwiw, they do have slightly different boiling points (THC: 157 degrees C; CBD: 160 degrees C). There are a few growers in Colorado experimenting with selective breeding to develop high CBD marijuana strains but I understand that so far the best they have is a strain which yields a 25% probability (1 in every 4 seedlings) of a high CBD plant. But they need to test each individual plant to make the proper selection. Bluebird Botanicals sells CBD oil but its looks like its a pretty low a concentration (250 mg CBD per ounce). I see they also have an atomizer product which might be better being 4x more potent:
http://www.bluebird-..._Vaporizers.php
Burning any kind of oil generates both toxic and carcinogenic products that you wouldn't want to inhale. Or even eat. Lower temperature vaporization might be a better approach. But I'm a little suspicious of the Propylene Glycol, which I think is the same vehicle used in most electronic nicotine cigarettes. Wax extraction might be better, increasing CBD concentration while leaving the Propylene Glycol out.
Howard
What I've been reading and seeing on videos (I'm no expert on this), is that the CBD works best if it has a miniscule amount of THC along with it and doesn't work well at all if the THC and other Cannabinoids have been removed. Project CBD supports using the whole plant as opposed to stripping out all the THC and other Cannabinoids as some of the pharmaceutical companies are doing. http://www.projectcbd.org/.
I've never grown marijuana, but I've been seeing and hearing about these high CBD low THC seeds and clones being sold. For example, http://canadianhempc...roducts_id=2785 and http://www.medicalja...nnabidiol-cbd/#. Synergy Wellness in California sells high CBD marijuana and the clones. http://synergycbd.co...b-rich-strains/. If you live in a State where medical marijuana is legal and you have a doctor's prescription and the necessary card, they'll mail it to you, but won't mail the clones. You have to pick those up directly.
I agree don't smoke the stuff. Vaporizing would be better. However, I've read the Washington Post article about research that shows smoking marijuana doesn't cause cancer, but instead protects against it. http://www.washingto...6052501729.html. I was led to this article from an article called 5 Amazing Things You Didn't Know About Marijuana at http://www.chicagono...bout-marijuana/. This article debunks the myths surrounding marijuana.
#118
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Posted 22 September 2014 - 04:20 AM
What I've been reading and seeing on videos (I'm no expert on this), is that the CBD works best if it has a miniscule amount of THC along with it and doesn't work well at all if the THC and other Cannabinoids have been removed. Project CBD supports using the whole plant as opposed to stripping out all the THC and other Cannabinoids as some of the pharmaceutical companies are doing. http://www.projectcbd.org/.
Did a little digging and found this Alzheimer's study with mice showing the combination of CBD & THC to be synergistic:
Cannabis-Based Medicine Reduces Multiple Pathological Processes in AβPP/PS1 Mice.
Several recent findings suggest that targeting the endogenous cannabinoid system can be considered as a potential therapeutic approach to treat Alzheimer's disease (AD). The present study supports this hypothesis demonstrating that delta-9-tetrahydrocannabinol (THC) or cannabidiol (CBD) botanical extracts, as well as the combination of both natural cannabinoids, which are the components of an already approved cannabis-based medicine, preserved memory in AβPP/PS1 transgenic mice when chronically administered during the early symptomatic stage. Moreover, THC + CBD reduced learning impairment in AβPP/PS1 mice.
...
In summary, the present findings show that the combination of THC and CBD exhibits a better therapeutic profile than each cannabis component alone and support the consideration of a cannabis-based medicine as potential therapy against AD.
Also came across a glaucoma study that found THC partially effective alone but got better results with CBD alone as well as in combination with THC:
Neuroprotective effect of THC and CBD in retinal neurotoxicity
The neuroprotection by THC and CBD was because of attenuation of peroxynitrite. The effect of THC was in part mediated by the cannabinoid receptor CB1. These results suggest the potential use of CBD as a novel topical therapy for the treatment of glaucoma.
At least for these effects, CBD seems to work by itself but is indeed more effective along with THC.
Howard
#119
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Posted 26 December 2015 - 09:34 PM
Here are some links on this topic worth reading. I think they're on to something with this in my opinion.
Expert testifies: Cannabis helps slow aging!, at http://www.dutch-pas...lps-slow-aging/
How Cannabinoids May Slow Brain Aging, at http://healthland.ti...ow-brain-aging/
Medical Marijuana and Aging, at http://medicalmariju...e.cfm?artID=826
Marijuana is "anti-aging" and "curative" drug, speakers say at Kalamazoo seminar, at http://www.mlive.com...ing_and_cu.html
#120
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Posted 27 December 2015 - 02:58 AM
A long time ago I did spend quite a long time in the cannabis plantations in the Morocco mountains, I lived there with the farmers and I lived their everyday reality.
For whom who doesn't know in that area cannabis growing is perfectly legal and basically the only activity possible for farmers, everything is cannabis, even the cows do eat the cannabis leftovers because there is nothing else to graze on.
Contrary of what most may think not everybody smokes pot or hashish there, roughly only about 50% of the male population (females don't smoke), some started smoking very early, probably when around 7-8 years old, I witnessed many of those individuals looking as young boys while being already full adults, something like a 25 years old looking like a 12 years boy or so.
Maybe just growth inhibition (maybe tobacco induced) and not really antiaging.
I am not sure if I can state that every smokers there was looking much younger than their age but certainly there was kind of a trend in that direction.
Consider that a smoker there has unlimited access all year long to all he is willing to smoke and likely enough if one is a smoker does smoke everyday for all his life...and we are not talking about just a couple of joints a day, that is an almost non stop process of lighting up a joint with the roach of the previous one from dawn to bed time.
Unfortunately they always use tobacco to mix pot or hashish which will false a bit any observation of this peculiar population, but nevertheless an antiaging effect of some kind is possibly seen.
Probably an organized research on these people could yield interesting results.
Consider cows do eat cannabis leftovers, since milk and homemade butter are a staple in the diet of everybody there (women and non smokers too) some cannabinoids are consumed by everybody, infants included (but not tobacco for the non smokers).
I recall a quite healthy looking population, some cases of alopecia areata probably due to nutritional deficiencies but not much else.
There were no hospitals and doctors for miles.
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