• Log in with Facebook Log in with Twitter Log In with Google      Sign In    
  • Create Account
  LongeCity
              Advocacy & Research for Unlimited Lifespans

Photo
- - - - -

Resveratrol and Cataracts


  • Please log in to reply
2 replies to this topic

#1 maxwatt

  • Guest, Moderator LeadNavigator
  • 4,949 posts
  • 1,625
  • Location:New York

Posted 12 May 2008 - 04:26 PM


Resveratrol prevented or reduced the severity of cataracts in a rat model. The paper suggests it would help prevent human senile cataract.

Curr Eye Res. 2006 Feb;31(2):147-53. Links
The effect of resveratrol in experimental cataract model formed by sodium selenite.Doganay S, Borazan M, Iraz M, Cigremis Y.
Department of Ophthalmology, Inonu University Medical Faculty, Turgut Ozal Medical Center, Malatya, Turkey. sdoganay2inonu.edu.tr

PURPOSE: To investigate if resveratrol can prevent sodium selenite-induced experimental cataract model in rats. METHODS: Forty-eight Spraque-Dawley rat pups were divided into 3 treatment groups: (1) normal saline-% 5 ethanol injected i.p. on postpatum day 10; (2) Na selenite (30 nmol/g body wt) injected s.c on day 10; (3) Na selenite s.c on day 10+resveratrol (40 mg/kg) i.p on days 10-13. On day 21, cataract development was graded by slit-lamp examination and photography. Encapsulated lenses and erythrocytes were analyzed for reduced glutathione (GSH) and malondialdehyde (MDA), a marker of lipid peroxidation. Lenses were also analyzed for total nitrite (TN). RESULTS: All control lenses in group 1 were clear. In group 2, all rats developed cataracts (grade 3-grade 6), whereas in group 3, only 9 of 16 rats developed cataracts (grade 2-grade 3). The difference of cataract frequency between groups 2 and 3 was statistically significant (p<0.05). Group 3 lenses and erythrocytes had higher mean GSH and lower mean MDA levels than those in group 2 (p<0.05). TN was highest in group 3 and lowest in group 1 (p<0.05). CONCLUSIONS: Resveratrol suppressed selenite-induced oxidative stress and cataract formation in rats. This protective effect was supported by higher GSH and lower MDA in lens and erythrocytes. The presence of oxidative stress in selenite cataract development and its prevention by resveratrol support the possibility that high natural consumption of resveratrol in food can help prevent human senile cataract.

PMID: 16500765



#2 VictorBjoerk

  • Member, Life Member
  • 1,763 posts
  • 91
  • Location:Sweden

Posted 12 May 2008 - 10:03 PM

Could betacarotenes prevent cataracts with the same effectiveness?

Click HERE to rent this advertising spot to support LongeCity (this will replace the google ad above).

#3 maxwatt

  • Topic Starter
  • Guest, Moderator LeadNavigator
  • 4,949 posts
  • 1,625
  • Location:New York

Posted 13 May 2008 - 12:58 AM

Could betacarotenes prevent cataracts with the same effectiveness?


No, unless you are a smoker; for smokers, it appeared to reduce risk of cataract extraction by a quarter in the study quoted below. For non-smokers, no difference was found. We don't have human studies for resveratrol and cataracts, but it reduced the rats' incidence by about 43%. Direct comparisons of the data in these studies is not conclusive by any means. Other carotinoids tnan beta c arotend, such as lutein and zeaxanthin , may have a slight positive effect in non-smokers.

Arch Ophthalmol. 2003 Mar;121(3):372-8.Links
A randomized trial of beta carotene and age-related cataract in US physicians.Christen WG, Manson JE, Glynn RJ, Gaziano JM, Sperduto RD, Buring JE, Hennekens CH.
Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, 900 Commonwealth Ave E, Third floor, Boston, MA 02215-1204, USA. wchristen@rics.bwh.harvard.edu

OBJECTIVE: To examine the development of age-related cataract in a trial of beta carotene supplementation in men. DESIGN: Randomized, double-masked, placebo-controlled trial. METHODS: Male US physicians aged 40 to 84 years (n = 22 071) were randomly assigned to receive either beta carotene (50 mg on alternate days) or placebo for 12 years. MAIN OUTCOME MEASURES: Age-related cataract and extraction of age-related cataract, defined as an incident, age-related lens opacity, responsible for a reduction in best-corrected visual acuity to 20/30 or worse, based on self-report confirmed by medical record review. RESULTS: There was no difference between the beta carotene and placebo groups in the overall incidence of cataract (998 cases vs 1017 cases; relative risk [RR], 1.00; 95% confidence interval [CI], 0.91-1.09) or cataract extraction (584 vs 593; RR, 1.00; 95% CI, 0.89-1.12). In subgroup analyses, the effect of beta carotene supplementation appeared to be modified by smoking status at baseline (P =.02). Among current smokers, there were 108 cases of cataract in the beta carotene group and 133 in the placebo group (RR, 0.74; 95% CI, 0.57-0.95). Among current nonsmokers, there was no significant difference in the number of cases in the 2 treatment groups (884 vs 881; RR, 1.03; 95% CI, 0.94-1.13). The results for cataract extraction appeared to be similarly modified by baseline smoking status (P =.05). CONCLUSIONS: Randomized trial data from a large population of healthy men indicate no overall benefit or harm of 12 years of beta carotene supplementation on cataract or cataract extraction. However, among current smokers at baseline, beta carotene appeared to attenuate their excess risk of cataract by about one fourth.

PMID: 12617708






1 user(s) are reading this topic

0 members, 1 guests, 0 anonymous users