Looking at the past reviews can put the current ones in perspective. I would be interested in comments on what has changed since then.
These are notes from CRIII presentation by Paul McGlothin titled 'Resveratrol: A CR Memetic?'
http://www.caloriere...09-summary.html
Speaker 9: Paul McGlothin - Resveratrol: A CR Memetic?
Paul's philosophy - Slight hormesis through denial is a good thing.
Paul is VERY careful to weigh pros and cons of new supplements.
Tries to make judgment call on short and long term side effects.
Careful to assess and evaluate everything that goes into his body.
Going to present results from his very small Resveratrol "study"
Not trying to convince us to take resveratrol, or not.
Resveratrol Study Goals:
* Two people in "study" - simply looking for patterns. Not claiming anything definitive. More tantalizing than anything else.
* To test in humans the positive results of Konrad Howitz of resveratrol On SIRT1 activation, which improved cell survival.
Chose Longevinex resveratrol supplement for target of test.
Paul tested resveratrol's ability to maintain low glucose. Had high GI pureed sweet potato + olive oil test meal, either preceded by resveratrol or not. Glucose over the next couple hours was 10% lower when meal preceded by resveratrol. Single test.
Also observed his fasting glucose about 10% lower w/ resveratrol.
Researcher has told Paul that he has seen same effect of resveratrol in mice.
Paul convinced low glucose a good thing - particularly for improved mental focus.
So we in the audience should be asking - is glucose low because of extra insulin sucking it into cells, which could be bad?
Research seems to show resveratrol BLOCKS glucose uptake in the gut, delaying absorption.
Masoro question: is the glucose eventually getting absorbed, or is it getting flushed in the feces?
Paul Answer: He's not sure. His suspicion is that it is just being delayed.
But could it also be preventing glucose uptake by other (non-gut) cells as well?
Paul takes resveratrol 40 minutes before meal in order to slow down glucose uptake. He and Meredith take a single 50mg table of Longevinex resveratrol per day.
Resveratrol and Nitric Oxide
Nitric Oxide important:
* signal molecule
* Fights infection
* Reduces blood pressure
* Better blood flow - more nocturnal erections
Dark side of Nitric Oxide:
* Gets converted into peroxynitrite, which is linked to cell damage.
Resveratrol seems to increase nitric oxide.
To see if this is happening, Paul and Meredith measured lipid peroxides (isoprostanes). Resveratrol seems to reduce lipid peroxides and a couple other measures of cell damage. So he doesn't *think* cells are being damaged by resveratrol.
Resveratrol CR mimetic effects:
* Paul's body temp drops from 97.1 to 96.7 when taking resveratrol. Repeatable.
* Platelet count goes down with resveratrol
* Liver function - to make sure liver not being damaged:
o No sign of damage to liver. In fact ALT (marker of liver cell death) went down with resveratrol - repeatable.
* C-reactive Protein (CRP) - Low w/ resveratrol. No before data.
CR practitioners burn a lot of fat. Markers of cellular fat burning went up. Don't know if good or bad. Better than burning proteins (muscle).
Masoro comment: CR'ed rats show no preferential burning of fat in steady state. CR and AL rats use the same proportions of fuels.
Masoro comment: If resveratrol is blocking glucose uptake, and causing the body to shift to burning more fat than glucose (a VERY big if, very speculative), than it may not be a CR mimetic.
Study shows resveratrol may arrest cell division in a certain phase. Some evidence that Paul's cell cycling is also unusual, looks like less proliferation. Good or bad?
Now what about Resveratrol and the SIRT genes?
Importance first discovered in yeasts.
SIRT-1 involved in a lot of pathways. Insulin, inflammation pathways, apoptosis, PPAR-gamma, P53 etc.
Low P53 seems to be an indicator of of SIRT1 activity. Paul's p53 is reduced. Encouraging.
Stay tuned to next talk for more - Konrad Howitz
P53 is cancer protective gene. Why would we want to downregulate it?
Paul and Meredith have low to normal markers of cancer (PSA etc.) - encouraging, given their low p53.
Curcumin upregulates p53, and increases apoptosis.
Resveratrol downregulates p53, and decreases apoptosis.
May not want to take curcurmin and resveratrol at same time.
Resveratrol, fish oil and aspirin all thin platelets. Might not want to take them all.
Healing might be slow on resveratrol. Need cell proliferation to heal, may not want to take resveratrol after injury...
Paul says we need to question him and his regime.
Paul's philosophy: "A lot has changed since I saw you last."
Don't take anything he says as gospel. His regime is always changing, and next week he may find something that changes everything.
Hopes his experiences will inspire us to do our own testing/experimentation with all aspects of our lifestyle.
