5 replies to this topic

[maxwatt]

Substances that increase cAMP in the brain improve memory.
Resveratrol increases cAMP.
Resveratrol crosses the blood-brain barrier.

To complete the syllogism, resveratrol therefor should improve memory.

Have any of you high-dose users noticed such an effect? It should manifest a faster learning, easier recall of facts and such. This can be highly subjective, but work situations,for instance, might provide a somewhat objective measure.

Anyone?

[ilanso]

Substances that increase cAMP in the brain improve memory.
Resveratrol increases cAMP.
Resveratrol crosses the blood-brain barrier.

To complete the syllogism, resveratrol therefor should improve memory.

Have any of you high-dose users noticed such an effect? It should manifest a faster learning, easier recall of facts and such. This can be highly subjective, but work situations,for instance, might provide a somewhat objective measure.

Anyone?

I'm sure there were plenty of such effects, but they're so hard to recall
On a serious note, as far as the BBB crossing, this was done via IP; is it also true PO?

This study demonstrated for the first time that resveratrol, a polyphenolic antioxidant, can cross the blood-brain barrier and exert protective effects against cerebral ischemic injury. (PMID: 12470882)

There is also this pending trial:

Trial of a Nutritional Supplement in Alzheimer's Disease

We are seeking patients with Alzheimer's disease to participate in a research study on an antioxidant formula containing resveratrol. Some study participants will receive the formula and some will receive a placebo (sugar pill). Participation in the study includes memory testing, neurological exams and blood tests. Resveratrol may reduce brain cell damage caused by harmful chemical byproducts. This study is investigating if resveratrol can help memory and thinking of Alzheimer's disease patients. A previous study examining the effects of resveratrol on the cognition of Alzheimer's disease patients has had encouraging results. However, the Food and Drug Administration (FDA) has not yet approved resveratrol for the treatment of Alzheimer's disease. The study will be conducted over 12 months and is funded by the Alzheimer's Association. For more information, please contact our research coordinator at (212) 241-8329. GCO #05-1394 (0001), Principal Investigator: Mary Sano, Ph.D., MSSM IRB approved through 4/30/2008.

[inawe]

I'm taking a lot of resveratrol because is very good for the memory.
But I don't remember why.
Oh yeh, it prevents my neurons from getting rusty:

Biochem Biophys Res Commun. 2008 May 15
Dietary resveratrol administration increases MnSOD expression and activity in mouse brain.Robb EL, Winkelmolen L, Visanji N, Brotchie J, Stuart JA.
Department of Biological Sciences, Brock University, 500 Glenridge Road, St. Catharines, Ont., Canada.

trans-Resveratrol (3,4',5-trihydroxystilbene; RES) is of interest for its reported protective effects in a variety of pathologies, including neurodegeneration. Many of these protective properties have been attributed to the ability of RES to reduce oxidative stress. In vitro studies have shown an increase in antioxidant enzyme activities following exposure to RES, including upregulation of mitochondrial superoxide dismutase, an enzyme that is capable of reducing both oxidative stress and cell death. We sought to determine if a similar increase in endogenous antioxidant enzymes is observed with RES treatment in vivo. Three separate modes of RES delivery were utilized; in a standard diet, a high fat diet and through a subcutaneous osmotic minipump. RES given in a high fat diet proved to be effective in elevating antioxidant capacity in brain resulting in an increase in both MnSOD protein level (140%) and activity (75%). The increase in MnSOD was not due to a substantial proliferation of mitochondria, as RES treatment induced a 10% increase in mitochondrial abundance (Citrate Synthase activity). The potential neuroprotective properties of MnSOD have been well established, and we demonstrate that a dietary delivery of RES is able to increase the expression and activity of this enzyme in vivo.

PMID: 18486604

[maxwatt]

I'm taking a lot of resveratrol because is very good for the memory.
But I don't remember why.
Oh yeh, it prevents my neurons from getting rusty:

Biochem Biophys Res Commun. 2008 May 15
Dietary resveratrol administration increases MnSOD expression and activity in mouse brain.Robb EL, Winkelmolen L, Visanji N, Brotchie J, Stuart JA.
Department of Biological Sciences, Brock University, 500 Glenridge Road, St. Catharines, Ont., Canada.

trans-Resveratrol (3,4',5-trihydroxystilbene; RES) is of interest for its reported protective effects in a variety of pathologies, including neurodegeneration. Many of these protective properties have been attributed to the ability of RES to reduce oxidative stress. In vitro studies have shown an increase in antioxidant enzyme activities following exposure to RES, including upregulation of mitochondrial superoxide dismutase, an enzyme that is capable of reducing both oxidative stress and cell death. We sought to determine if a similar increase in endogenous antioxidant enzymes is observed with RES treatment in vivo. Three separate modes of RES delivery were utilized; in a standard diet, a high fat diet and through a subcutaneous osmotic minipump. RES given in a high fat diet proved to be effective in elevating antioxidant capacity in brain resulting in an increase in both MnSOD protein level (140%) and activity (75%). The increase in MnSOD was not due to a substantial proliferation of mitochondria, as RES treatment induced a 10% increase in mitochondrial abundance (Citrate Synthase activity). The potential neuroprotective properties of MnSOD have been well established, and we demonstrate that a dietary delivery of RES is able to increase the expression and activity of this enzyme in vivo.

PMID: 18486604

Th implication is the standard diet did not show the positive effect that the high-fat did, but without the complete paper that's just a good guess. Such a result might be due to better bioavailability of a hydrophobic molecule with the high fat diet.

[edward]

I'm taking a lot of resveratrol because is very good for the memory.
But I don't remember why.
Oh yeh, it prevents my neurons from getting rusty:

Biochem Biophys Res Commun. 2008 May 15
Dietary resveratrol administration increases MnSOD expression and activity in mouse brain.Robb EL, Winkelmolen L, Visanji N, Brotchie J, Stuart JA.
Department of Biological Sciences, Brock University, 500 Glenridge Road, St. Catharines, Ont., Canada.

trans-Resveratrol (3,4',5-trihydroxystilbene; RES) is of interest for its reported protective effects in a variety of pathologies, including neurodegeneration. Many of these protective properties have been attributed to the ability of RES to reduce oxidative stress. In vitro studies have shown an increase in antioxidant enzyme activities following exposure to RES, including upregulation of mitochondrial superoxide dismutase, an enzyme that is capable of reducing both oxidative stress and cell death. We sought to determine if a similar increase in endogenous antioxidant enzymes is observed with RES treatment in vivo. Three separate modes of RES delivery were utilized; in a standard diet, a high fat diet and through a subcutaneous osmotic minipump. RES given in a high fat diet proved to be effective in elevating antioxidant capacity in brain resulting in an increase in both MnSOD protein level (140%) and activity (75%). The increase in MnSOD was not due to a substantial proliferation of mitochondria, as RES treatment induced a 10% increase in mitochondrial abundance (Citrate Synthase activity). The potential neuroprotective properties of MnSOD have been well established, and we demonstrate that a dietary delivery of RES is able to increase the expression and activity of this enzyme in vivo.

PMID: 18486604

Th implication is the standard diet did not show the positive effect that the high-fat did, but without the complete paper that's just a good guess. Such a result might be due to better bioavailability of a hydrophobic molecule with the high fat diet.

Or the high fat diet improved memory all on its own and Resveratrol was just along for the ride...

from my thread on ketogenic diets (high fat, moderate protein, ultra low carb) http://www.imminst.o...o...20768&st=0:

Do ketogenic diets make you smarter? Well evidence shows increased mitochondrial density and better utilization of energy (I posted these studies early in this thread)... This guy tested rats on keto vs. non keto (he studies keto as a treatment for epilepsy) any ways here info from him. http://w3.ouhsc.edu/...ope/ketogen.htm halfway down the page.

Dr. Stafstrom described several experiments in which rats given ketogenic diets were compared with rats on normal diets as various parameters of cognition and behavior were tested. In general, the rats on the ketogenic diet did better in several tests, such as the "water maze", which measures the ability to learn and remember the location of food on a platform in a pool of water through which the rat has to swim to reach the food. "I am not willing to say that the ketogenic diet makes rats smarter, but at least it's clear that it doesn't make them any dumber", said Dr. Stafstrom, and this observed effect correlates with observations in children with severe epilepsy on the ketogenic diet who experience improvements in mood, behavior, and cognition. Unfortunately, this improvement carries with it an increase in activity, possibly hyperactivity, in terms of awareness and exploration of the surroundings; this may correlate with observations of increased irritability in some children on the diet.

Edited by edward, 21 May 2008 - 08:15 PM.

[inawe]

Another paper by the Stuart group:
Biochem Biophys Res Commun. 2008 Mar 7;367(2):406-12. Epub 2007 Dec 31. Links
Molecular mechanisms of oxidative stress resistance induced by resveratrol: Specific and progressive induction of MnSOD.Robb EL, Page MM, Wiens BE, Stuart JA.
Department of Biological Sciences, Brock University, 500 Glenridge Road, St. Catharines, Ont., Canada L2S 3A1.

trans-Resveratrol (3,4',5-trihydroxystilbene; RES), a polyphenol found in particularly high concentrations in red wine, has recently attracted intense interest for its potentially beneficial effects on human health. Here, we report the effects of long-term exposure to micromolar concentrations of RES on antioxidant and DNA repair enzyme activities in a human cell line (MRC-5). RES had either no effect on, or reduced the activities of glutathione peroxidase, catalase and CuZn superoxide dismutase (SOD), in treatments lasting up to 2 weeks. RES failed to induce activities of the DNA base excision repair enzymes apurinic/apyrimidinic endonuclease and DNA polymerase beta. However, it dramatically and progressively induced mitochondrial MnSOD expression and activity. Two weeks exposure to RES increased MnSOD protein level 6-fold and activity 14-fold. Thus, long-term exposure of human cells to RES results in a highly specific upregulation of MnSOD, and this may be an important mechanism by which it elicits its effects in human cells.
PMID: 18167310

OK, it's in vitro and I don't remember where that cell line is from. But RSV seems to be the WD40 for the mitochondria.