33 replies to this topic

[hmm]

Back in early March I started taking 400 mg (50% pure) Now RSV purchased from IHerb (2, 200-mg veggie caps, one in the morning and one at night), and this erased a lot of joint pain (knees, hips), got rid of some troublesome achilles tendonitis inflammation, and minimized recovery times from once-a-week sports exertions. Was able to resume a rigorous multi-sport exercise routine that had been lagging due to chronic injuries. I then ramped up to 800 mg of the Now product. At this point, laxative effect drove me to order 99% powder from Vital Prime. When the Vital Prime arrived toward the end of April, I increased dosage to 2 grams a day. (1 gram morning, one gram night, mixed with tablespoon of vodka and then doused with grapefruit juice.)

I need to post a correction, having obtained access to an actual scale. From reading these threads, I had concluded that a gram of powder would be the equivalent of half a teaspoon, and that a full teaspoon of powder would be two grams, and this is how I determined the amounts listed above. However, the scale showed me that my particular measuring spoons yield .5 grams for half a teaspoon and 1.4 grams for a full teaspoon (a full teaspoon being 3 times that of a half!). When I thought I was taking 2 grams per day, I was taking a half teaspoon in the morning and then again in the evening, for an actual total of a gram per day. Then, when I thought I was taking 4 grams per day, I was actually using the full teaspoon measure twice a day for a total of 2.8 grams per day. Between variations in the consistency of the powders and probably even wider variations in measuring spoons, powder RSVers should pay careful heed to MaxWatt's advice about getting access to a reliable scale so they will know their actual dosage levels.

[missminni]

From the way I am understanding this now, it seems like I got the worst of both worlds. So NF-KB activation actually falls right into HSV's plan? If NF-KB suppression was really a big factor in my situation, then I either should have gotten hit by one virus or the other, rather than both. Maybe my immune system is just generally shot for some other reason...

It could be that the herpes was a fluke, and the RSV had something to do with the shingles. Or maybe they were both flukes. I think that you can at least make a better case for the shingles RSV connection.

Yes maybe NFKB has something to do with the shingles, but it looks like I was trying to make NFKB into too much of a factor in these outcomes. From googling around it appears that NFKB inflammation is associated with eczema. As much RSV as MissMini was taking, she should have been suppressing NF-KB, and suppressing NF-KB appears to be a favored way to treat eczema rather than cause it. Same with me and my herpes simplex. I started taking a gram again yesterday, and like many times before, woke up at 2 or 3 in the morning and didn't sleep again until around 6AM. Experience told me that I wouldn't really be too tired the next day because of the RSV. But what kinds of various factors in my system might I be disrupting by foregoing all that sleep, that might indirectly result in some kind of unexpected viral attack?

I just saw this. Please help me understand...Res suppresses NF-KB and suppressing NF_KB stops eczemza? Also, I have to agree that lack of sleep, which I was suffering from when I first got eczema, is a major contributing factor.

[hmm]

From the way I am understanding this now, it seems like I got the worst of both worlds. So NF-KB activation actually falls right into HSV's plan? If NF-KB suppression was really a big factor in my situation, then I either should have gotten hit by one virus or the other, rather than both. Maybe my immune system is just generally shot for some other reason...

It could be that the herpes was a fluke, and the RSV had something to do with the shingles. Or maybe they were both flukes. I think that you can at least make a better case for the shingles RSV connection.

Yes maybe NFKB has something to do with the shingles, but it looks like I was trying to make NFKB into too much of a factor in these outcomes. From googling around it appears that NFKB inflammation is associated with eczema. As much RSV as MissMini was taking, she should have been suppressing NF-KB, and suppressing NF-KB appears to be a favored way to treat eczema rather than cause it. Same with me and my herpes simplex. I started taking a gram again yesterday, and like many times before, woke up at 2 or 3 in the morning and didn't sleep again until around 6AM. Experience told me that I wouldn't really be too tired the next day because of the RSV. But what kinds of various factors in my system might I be disrupting by foregoing all that sleep, that might indirectly result in some kind of unexpected viral attack?

I just saw this. Please help me understand...Res suppresses NF-KB and suppressing NF_KB stops eczemza? Also, I have to agree that lack of sleep, which I was suffering from when I first got eczema, is a major contributing factor.

Missminni, I can't presume to explain anything besides the mystery as I see it. I wonder though, if my mystery might dovetail with a request I think you made for RSV'ers to get some blood work done to try to figure out what substances (such as DHEA) might be getting depleted from their systems as a result of taking RSV:
If you google NFKB and eczema, you will find numerous studies where substances are (quite successfully) being used to fight eczema by suppressing the NFKB immune response. I think you will also find studies that show that RSV inhibits the NFKB immune response. If those were the only factors in play then theoretically taking RSV should have prevented eczema for you rather than caused it. I guess those factors were largely overridden by other effects that RSV had, perhaps those that (I think) you have speculated about, such as the lowering of estrogen or other substances in your blood.
RSV also theoretically stops HSV, but it didn't stop it for me just like it didn't stop eczema for you. Again probably because those factors were overridden by more powerful ones. In my case, with the benefit of two months' hindsight, I am hoping that the more powerful factors were poor diet, lack of sleep, and physical over-exertion, caused by what I call "Resveratrol Man Syndrome". In the last 2 months, while not letting myself eat too poorly or lose much sleep or work out too hard, I have been able to consume first 1 gram and then 1.3 grams per day with negligible side effects. I intend to keep raising the dosage up 1/3 gram every month until side effects start popping up again...

*Resveratrol Man Syndrome is when a person thinks that since they are taking RSV, they are now entitled to skip their most nutritious meals 2 or 3 days a week (and replace them with any kind of sweeet/salty/greasy garbage that catches their fancy at odd hours), lose 3-5 hours of sleep night after night, and perform a rigorous 90-120-minute exercise routine every morning without taking any days off.

[missminni]

From the way I am understanding this now, it seems like I got the worst of both worlds. So NF-KB activation actually falls right into HSV's plan? If NF-KB suppression was really a big factor in my situation, then I either should have gotten hit by one virus or the other, rather than both. Maybe my immune system is just generally shot for some other reason...

It could be that the herpes was a fluke, and the RSV had something to do with the shingles. Or maybe they were both flukes. I think that you can at least make a better case for the shingles RSV connection.

Yes maybe NFKB has something to do with the shingles, but it looks like I was trying to make NFKB into too much of a factor in these outcomes. From googling around it appears that NFKB inflammation is associated with eczema. As much RSV as MissMini was taking, she should have been suppressing NF-KB, and suppressing NF-KB appears to be a favored way to treat eczema rather than cause it. Same with me and my herpes simplex. I started taking a gram again yesterday, and like many times before, woke up at 2 or 3 in the morning and didn't sleep again until around 6AM. Experience told me that I wouldn't really be too tired the next day because of the RSV. But what kinds of various factors in my system might I be disrupting by foregoing all that sleep, that might indirectly result in some kind of unexpected viral attack?

I just saw this. Please help me understand...Res suppresses NF-KB and suppressing NF_KB stops eczemza? Also, I have to agree that lack of sleep, which I was suffering from when I first got eczema, is a major contributing factor.

Missminni, I can't presume to explain anything besides the mystery as I see it. I wonder though, if my mystery might dovetail with a request I think you made for RSV'ers to get some blood work done to try to figure out what substances (such as DHEA) might be getting depleted from their systems as a result of taking RSV:
If you google NFKB and eczema, you will find numerous studies where substances are (quite successfully) being used to fight eczema by suppressing the NFKB immune response. I think you will also find studies that show that RSV inhibits the NFKB immune response. If those were the only factors in play then theoretically taking RSV should have prevented eczema for you rather than caused it. I guess those factors were largely overridden by other effects that RSV had, perhaps those that (I think) you have speculated about, such as the lowering of estrogen or other substances in your blood.
RSV also theoretically stops HSV, but it didn't stop it for me just like it didn't stop eczema for you. Again probably because those factors were overridden by more powerful ones. In my case, with the benefit of two months' hindsight, I am hoping that the more powerful factors were poor diet, lack of sleep, and physical over-exertion, caused by what I call "Resveratrol Man Syndrome". In the last 2 months, while not letting myself eat too poorly or lose much sleep or work out too hard, I have been able to consume first 1 gram and then 1.3 grams per day with negligible side effects. I intend to keep raising the dosage up 1/3 gram every month until side effects start popping up again...

*Resveratrol Man Syndrome is when a person thinks that since they are taking RSV, they are now entitled to skip their most nutritious meals 2 or 3 days a week (and replace them with any kind of sweeet/salty/greasy garbage that catches their fancy at odd hours), lose 3-5 hours of sleep night after night, and perform a rigorous 90-120-minute exercise routine every morning without taking any days off.

I agree. Lack of sleep especially. I suffered from the same syndrome.