Thanks. I am sure resveratrol will help your animals. A friend of mine whose ChowChow was limping for
almost two years started him on Resveratrol and he limps no more. The response was immediate. She saw an improvement the first day
and by the end of the week, the difference was dramatic. It would probably help your horse's glaucoma too according to the study below.
The final phase of the experiment evaluated the benefits of antioxidant treatment. Having designed a model to show how IOP elevation can induce oxidative stress and cell death, Dr. Liu and his colleagues wanted to see if they could reverse that process.The RGC-5 cell cultures were pretreated with the antioxidants resveratrol and quercetin (20 µm or 40 µm in dimethyl sulfoxide) for 30 minutes before undergoing 2 hours of elevated pressure (60 mm Hg). Results showed that pretreatment with resveratrol reduced the level of HNE adducts in the cell cultures by 70%, whereas quercetin pretreatment resulted in a 30% reduction in oxidative stress.Resveratrol is a compound found largely in the skin of red grapes and has been studied as a possible explanation for the "French paradox," the relatively low incidence of heart disease among the French, despite their high-fat diet. In addition, resveratrol is a compound that can mimic the effect of caloric restriction, which is the only proven method to elongate the life span of mammals. Quercetin is a flavonoid with antioxidant and anti-inflammatory properties.Although elevated pressure is a major risk factor for glaucoma, so, too, is aging. Since resveratrol appears to have some anti-aging properties in addition to other protective mechanisms, it might be beneficial in multiple ways, including reduction of oxidative stress levels, Dr. Liu said.Following that preliminary screening process, which showed that resveratrol was more effective than quercetin for reducing oxidative stress levels in cell cultures, Dr. Liu and his colleagues are following up by conducting further experiments in a mouse model of glaucoma. The mice are receiving these compounds in their food; scientists will subsequently study them to determine the presence of any protective effects on the RGC cells.Dr. Liu and his colleagues are conducting other studies to determine the potential role of oxidative stress in the chronic pattern of glaucoma pathology by studying different chronic animal models of glaucoma and even some patient samples. They are exploring the possibility of preventive methods or therapies developed from antioxidants or similar compounds for glaucoma patients.Findings from the three experiments appeared in the October issue of Investigative Ophthalmology and Visual Science (2007;48:4580-4589).
Well, I received my resveratrol today. Do you think starting the dog (50lbs) with 500 mg (99%) and gradually increasing is a good plan? The dosage for the horse (1100 lbs), however, is going to be a bit more difficult for me to determine.
Thanks, missminni, for this article and info.
Edited by free, 13 July 2008 - 09:30 AM.