6 replies to this topic

[cmorera]

http://v.mercola.com...sity-64320.aspx

Amazing Grape Compound Battles Obesity

Resveratrol, a compound present in grapes and red wine, can reduce the number of fat cells in your body. It may one day be used to treat or prevent obesity.

Past research found that resveratrol can protect mice from health problems related to obesity, mimicking the effects of calorie restriction. New research shows that it can also mimic the effects of calorie restriction in human fat cells.

Resveratrol inhibits pre-fat cells from increasing, and prevents them from converting into mature fat cells. Resveratrol also hindered fat storage, and reduced production of certain cytokines that may be linked to the development of obesity-related disorders.

interesting, this is only mere weeks after one study concluded fat cells were established in adolescence (set point theory)

http://www.google.co...i...nce&spell=1

[maxwatt]

http://v.mercola.com...sity-64320.aspx

Amazing Grape Compound Battles Obesity

Resveratrol, a compound present in grapes and red wine, can reduce the number of fat cells in your body. It may one day be used to treat or prevent obesity.

Past research found that resveratrol can protect mice from health problems related to obesity, mimicking the effects of calorie restriction. New research shows that it can also mimic the effects of calorie restriction in human fat cells.

Resveratrol inhibits pre-fat cells from increasing, and prevents them from converting into mature fat cells. Resveratrol also hindered fat storage, and reduced production of certain cytokines that may be linked to the development of obesity-related disorders.

interesting, this is only mere weeks after one study concluded fat cells were established in adolescence (set point theory)

http://www.google.co...i...nce&spell=1

Consider the source.

[cmorera]

Detailed results will be presented at The Endocrine Society's 90th Annual Meeting in San Francisco.

This study was partly funded by the German Research Association (Deutsche Forschungsgemeinschaft) and the Ministry of Science, Research and Arts (Ministerium fuer Wissenschaft, Forschung und Kunst), Baden-Wuerttemberg.

Passes the smell test to me

[maxwatt]

The study was done in vitro with preadipocytes. Possibly different effect in mature as opposed to adolescent and juvenile members of the species? No one here is recommending resveratrol for kids, but for all we know it might be good for them.

[TianZi]

interesting, this is only mere weeks after one study concluded fat cells were established in adolescence (set point theory)

http://www.google.co...i...nce&spell=1

1. If I recall correctly, the study you reference didn't conclude that fat cells did not develop after adolesence, because they do, but rather that the number of fat cells in the body is predominantly determined in adolesence, and that even after losing body fat mass, the fat cells never completely disappear, just shrink.

2. From the thread title, you seem to have misintrepreted the conclusions in the study. Copying from your own post they are as follows:

"Resveratrol inhibits pre-fat cells from increasing, and prevents them from converting into mature fat cells. Resveratrol also hindered fat storage, and reduced production of certain cytokines that may be linked to the development of obesity-related disorders."

Assuming you have quoted all of the relevant findings from the study, the study did not find that resveratrol reduced the number of existing fat cells.

Edited by TianZi, 19 June 2008 - 05:54 AM.

[edward]

just a note: Fat cell apoptosis is possible even in adults but very difficult under normal conditions, however under extreme conditions its possible ( starvation, training/diet or chemical means are needed) hence the set point theory.

[Hedgehog]

just a note: Fat cell apoptosis is possible even in adults but very difficult under normal conditions, however under extreme conditions its possible ( starvation, training/diet or chemical means are needed) hence the set point theory.

Low Sirt1 expression, which is upregulated by fasting, in human adipose tissue from obese women.
Pedersen SB, Olholm J, Paulsen SK, Bennetzen MF, Richelsen B. [1] 1Institute of Clinical Medicine, Aarhus University, Aarhus C, Denmark [2] 2Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus Sygehus, Aarhus C, Denmark.

Objective:Calorie restriction increases the life span in a number of different organisms. This effect is dependent upon activation of the Sirt1 enzyme, and many of the beneficial effects of calorie restriction can be mimicked using resveratrol, which activates the Sirt1 enzyme. Nothing is known about this system in human adipose tissue; therefore, we investigated this system in human adipose tissue.Design:Sirt1 mRNA was measured in adipose tissue biopsies from human volunteers before and after 6 days of total fasting. In addition, adipose tissue from lean and obese individuals was compared and in vitro investigations were performed.Results:Long-term total fasting (6 days) of nine human volunteers increased Sirt1 mRNA expression in subcutaneous adipose tissue more than twofold (0.197-0.454 arbitrary units, P<0.05). Likewise, lean women (n=12) had more than twofold higher Sirt1 expression in subcutaneous adipose tissue compared to obese women (n=12; 0.33-0.73 arbitrary units, P<0.05). Sirt1 was equally expressed in the stroma-vascular fraction and the isolated adipocyte fraction. Finally, in vitro, we demonstrated that resveratrol (a Sirt1 activator) significantly enhanced the lipolytic effect of epinephrine in human adipose tissue (P<0.05).Conclusion:Human adipose tissue contains Sirt1 and the expression of Sirt1 can be regulated by calorie restriction as in other species. Furthermore, we demonstrated that resveratrol affects human fat-cell metabolism similar to the effects in rodents (that is, increased epinephrine induced lipolysis). These findings indicated that the beneficial effects of calorie restriction in humans might involve the activation of Sirt1. Thus, based on these findings, we propose that Sirt1 might play important roles for the beneficial effects of calorie restriction in humans.International Journal of Obesity advance online publication, 17 June 2008; doi:10.1038/ijo.2008.78.