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Oligonol extends life in vivo?


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#1 cronnie

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Posted 05 July 2008 - 04:22 PM


The guys form super-smart claim:

Mice supplemented with Oligonol® over a long period live longer than their normal lifespan, suggesting that it may delay the ageing process

(at http://www.super-sma...ol-100-mg--0456 )

As far as i know there is no substance that makes mice live longer than normal lifespan. So this seems bs to me. Or are they on to something?

#2 tintinet

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Posted 11 July 2008 - 12:00 PM

The guys form super-smart claim:

Mice supplemented with Oligonol® over a long period live longer than their normal lifespan, suggesting that it may delay the ageing process

(at http://www.super-sma...ol-100-mg--0456 )

As far as i know there is no substance that makes mice live longer than normal lifespan. So this seems bs to me. Or are they on to something?



Haven't found the specific mouse life extension reference, yet, but found this!

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#3 edward

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Posted 11 July 2008 - 03:43 PM

Its a polyphenol from the Lychee fruit, yummy I love that fruit, haven't had it for awhile being all carb restricted and you really can only get fresh Lychee in Asia.

#4 edward

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Posted 11 July 2008 - 03:50 PM

I too cannot find the lifespan studies but here is the visceral fat study.

http://www.ncbi.nlm....Pubmed_RVDocSum

I am very curious about this as personally highly purified standardized polyphenol/flavonoid like substances seem to hold the best promise (bang for the buck) for health benefits from supplements (resveratrol, grape seed, pomegranate, green tea etc etc etc)

#5 cronnie

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Posted 11 July 2008 - 07:27 PM

thanks guys! That is pretty cool news. I am seriously thinking about adding this to my regimen.
Does anyone know about contra-indications or risk? (or a cheaper source...)

#6 tintinet

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Posted 13 July 2008 - 02:05 AM

thanks guys! That is pretty cool news. I am seriously thinking about adding this to my regimen.
Does anyone know about contra-indications or risk? (or a cheaper source...)


Cheaper source is fairly easy. Just search Google products and Yahoo! Shopping, etc.

#7 tham

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Posted 20 July 2008 - 08:40 AM

Lychee's pericarp is a cancer figher :

http://www.ncbi.nlm....l=pubmed_docsum

http://www.ncbi.nlm....l=pubmed_docsum

http://www.ncbi.nlm....l=pubmed_docsum

http://www.ncbi.nlm....l=pubmed_docsum

#8 tintinet

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Posted 20 July 2008 - 10:55 PM

Lychee's pericarp is a cancer figher :

http://www.ncbi.nlm....l=pubmed_docsum

http://www.ncbi.nlm....l=pubmed_docsum

http://www.ncbi.nlm....l=pubmed_docsum

http://www.ncbi.nlm....l=pubmed_docsum


I just opened my Source Naturals Oligonol 100 mg capsules and popped a couple. Nothing major to report, yet....

Edited by tintinet, 20 July 2008 - 10:56 PM.


#9 cronnie

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Posted 21 July 2008 - 04:34 PM

I bought a years supply today. If any effects i'll report.

#10 Castiel

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Posted 29 January 2014 - 10:57 PM

So this seems bs to me. Or are they on to something?

Googling gave a result for samp8 increase in mean lifespan

Oligonol increased the mean life span and this was statistically significant-"Modulation of infection-induced inflammation and locomotive deficit and longevity in senescence-accelerated mice-prone (SAMP8) model by the oligomerized polyphenol Oligonol."



#11 hav

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Posted 30 January 2014 - 04:14 PM

So this seems bs to me. Or are they on to something?

Googling gave a result for samp8 increase in mean lifespan

Oligonol increased the mean life span and this was statistically significant-"Modulation of infection-induced inflammation and locomotive deficit and longevity in senescence-accelerated mice-prone (SAMP8) model by the oligomerized polyphenol Oligonol."


Don't know that smap8 mice are a good model for general longevity. Samp8 mice are considered a good model for Alzheimer disease, however. There are lots of other studies on Oligonol in more normal mice and rats showing lots of good antioxidant effects, but I couldn't find any that mentioned finding a life extension effect. Here's a link to the samp8/oligonol study:

Modulation of infection-induced inflammation and locomotive deficit and longevity in senescence-accelerated mice-prone (SAMP8) model by the oligomerized polyphenol Oligonol.

Oligonol is produced from the oligomerization of polyphenols (typically proanthocyanidin from a variety of fruits such as lychees, grapes, apples, persimmons, etc.) and contains catechin-type monomers and oligomers of proanthocyanidins. The ability of Oligonol to affect infection-dependent eye inflammation, locomotion and longevity in senescence-accelerated prone mice (SAMP8) (a model of senescence acceleration and geriatric disorders with increased oxidative stress and neuronal deficit) was investigated. Oligonol (60mg/kg) significantly modulated the extent of inflammation scores in the eye of SAMP8 mice. Examination of the mice indicated infection with mouse hepatitis virus and pinworm (Syphacia obvelata) in both males and females and with the intestinal protozoa (trichomonad) in males. A comparison of the two groups (using log-rank test) and the difference in the mean life span between groups (using Student's t-test) indicated significant differences in survival (p=0.043) and the mean life span (p=0.033) in male SAMP8 mice. Oligonol increased the mean life span and this was statistically significant. In the open-field locomotive test, the 7-week-old SAMP8 mice crossed more than 40 partitioned lines in 1min. At 48-week-old control untreated male SAMP8 crossed 2 lines. The Oligonol-treated 48-week-old male SAMP8 mice crossed 17 lines however. The improved locomotive activity was statistically significant even after 36weeks in the Oligonol-treated male SAMP8 but this was not the case throughout the time course of the study in the Oligonol-treated female SAMP8. Thus Oligonol treatment to SAMP8 mice modulated the severity of infection-dependent inflammation, prolonged life-span and significantly improved locomotive activity indicating potential benefit to aging-associated diseases such as Alzheimer's or Parkinson's diseases. This presents potential for further research to define infection-dependent inflammation associated with degenerative conditions and the molecular mechanism of dietary antioxidant protection.


Note that the abstract above doesn't quantify the increased survival. It only mentions the researchers considered it statistically significant based on p-values of 0.043 and 0.033. The full text probably has better detail on that.

Btw, the above thread, which pre-dates the samp8 mouse study, may not be talking about exactly the same Oligonol used in that study. The thread seemed to be talking about a specific "improved" product that was extracted from lychee fruit and mixed with green tea extract and perhaps micronized to enhance absorption. The samp8 mouse study was conducted by researchers from Amino Up chemical Co in Japan and they likely used their commercial product described here:

http://www.aminoup.c...ducts/Oligonol/

A more common source would be to start with an extract of procyanidins from grape seed extract. Here's an early Oligonol study that first proposed it as a possible Alzheimer treatment that mentions the specific source used in the abstract:

Protective effects of oligomers of grape seed polyphenols against beta-amyloid-induced oxidative cell death.

beta-Amyloid (Abeta) is considered to be responsible for the formation of senile plaques that accumulate in the brains of patients with Alzheimer's disease (AD). There is compelling evidence supporting the notion that Abeta-induced cytotoxicity is mediated through the generation of reactive oxygen species (ROS). Recently, considerable attention has been focused on a wide array of non-vitamin antioxidants present in edible plants that are able to scavenge ROS, thereby protecting against oxidative damage. In this study, we have investigated the possible protective effects of formulated polyphenol oligomers (Oligonol) derived from grape seed extracts on Abeta-induced oxidative cell death. Rat pheochromocytoma (PC12) cells treated with Abeta exhibited increased accumulation of intracellular ROS and underwent apoptosis, as determined by positive in situ terminal end labeling, decreased mitochondrial membrane potential, and the cleavage of poly(ADP-ribose)polymerase. Oligonal attenuated Abeta-induced cytotoxicity, apoptotic features, intracellular ROS accumulation, and lipid peroxidation and increased the cellular glutathione pool. Moreover, Abeta transiently induced the activation of nuclear factor kappaB in PC12 cells, which was suppressed by pretreatment with Oligonol.


I only mention that because many follks believe that not all procyanidins are alike and the effects can vary depending on the source. Which seems to be supported by this study contrasting pentosidine formation in collagens while supplementing with grape seed extract compared to pine bark procyanidins.

Howard

Edited by hav, 30 January 2014 - 04:47 PM.

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#12 normalizing

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Posted 03 February 2014 - 02:02 AM

I bought a years supply today. If any effects i'll report.


when are you going to report ?

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#13 normalizing

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Posted 15 April 2014 - 02:48 AM

prolongation required






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