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SIRT1 activation effects CLOCK genes


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#1 VP.

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Posted 29 July 2008 - 04:00 AM


Anyone notice any changes in their circadian rhythms? I haven't.

Resveratrol's target is SIRT1, one of a group of proteins called sirtuins that maintain cellular function. But the researchers -- one group from the University of California, Irvine and another from the University of Geneva -- say that SIRT1 is also an important piece of our biological clocks: it links cell-level ciradian rhythms with body-level physiology, keeping appetite and wakefulness in a smoothly-regulated cycle.

http://blog.wired.co...evity-drug.html

" While it remains a matter of speculation, the findings suggest that drugs that inhibit or activate SIRT1 might have an effect on the clock," added Gad Asher of University of Geneva in Switzerland, noting that such treatments might be a help to people suffering from circadian sleep disturbances. That idea could be easily tested by giving mice resveratrol, a SIRT1-boosting ingredient found in red wine, and examining its effects on clock function, he added.

The physiology and behavior of mammals are subject to daily oscillations driven by an endogenous circadian clock, explained Asher's team led by Ueli Schibler. In mammals, the circadian timing system is composed of a central pacemaker in the brain and subsidiary oscillators in most peripheral tissues. While light-dark cycles are the predominant cue for the brain's pacemaker, cyclic feeding behavior has a strong effect on clocks operating in many other tissues.

http://www.scienceda...80724123246.htm

Is there an optimum time of day to take resveratrol?

#2 DaffyDuck

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Posted 29 July 2008 - 11:00 AM

Anyone notice any changes in their circadian rhythms? I haven't.


There is more discussion here:
http://www.imminst.o...ism-t23381.html

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