One member has reported his MS-like symptoms were reduced by using curcumin, and eliminated by using resveratrol. A possible mechanism is the inhibition of TNFalpha.
TNFalpha is a pro-inflammatory cytokine, which has been associated with demyelinating disorders, including Multiple Sclerosis. It reduces the gene expression (PPARdelta), responsible for oligodendrocyte survival and differentiation in oligodendrocyte progenitor cells. The reduction in PPARdelta gene expression results in reductions in myelin synthesis, maturation and turnover (1). TNFalpha is inhibited by green tea, curcumin, (2), quercetin (3) and resveratrol (4). A neighbor of mine with advanced MS plans to begin using resveratrol. I will report on the results.
1) Cimini A, Bernardo A, Cifone MG, Di Marzio L, Di Loreto S, Cifone G, Di Muzio L. "TNF alpha downregulates PPARdelta expression in olidogdenrocyte progenitor cells: implications for demyelinating diseases." Glia 2003, 41(1): 3-14.
2) Sato M, Miyazaki T et al. "Quercetin, a bioflavonoid, inhibits the induction of interleukin 8 monocyte chemoattractant protein-1 expression by tumor necrosis factor alpha in cultured human synovial cells. J Rheumatol, 1997; 24:1680-1684.
3) Jobin C, Bradham C et al. "Curcumin blocks cytokine-mediated NF-kappa-B actaivation and proinflammatory gene expression by inhibiting inhibiting factor I-kappa B kinase activity. J Immunol, 1999; 163: 3474-3483.
4) Wang MJ, Huang HM, Hsieh SJ, Jeng KC, Kuo JS. " Resveratrol inhibits interleukin-6 production in cortical mixed glial cells under hypoxia/hypoglycemia followed by reoxygenation." J Neuroimmunol 2001 Jan 1;112(1-2):28-34