3 replies to this topic

[maxwatt]

One member has reported his MS-like symptoms were reduced by using curcumin, and eliminated by using resveratrol. A possible mechanism is the inhibition of TNFalpha.

TNFalpha is a pro-inflammatory cytokine, which has been associated with demyelinating disorders, including Multiple Sclerosis. It reduces the gene expression (PPARdelta), responsible for oligodendrocyte survival and differentiation in oligodendrocyte progenitor cells. The reduction in PPARdelta gene expression results in reductions in myelin synthesis, maturation and turnover (1). TNFalpha is inhibited by green tea, curcumin, (2), quercetin (3) and resveratrol (4). A neighbor of mine with advanced MS plans to begin using resveratrol. I will report on the results.

1) Cimini A, Bernardo A, Cifone MG, Di Marzio L, Di Loreto S, Cifone G, Di Muzio L. "TNF alpha downregulates PPARdelta expression in olidogdenrocyte progenitor cells: implications for demyelinating diseases." Glia 2003, 41(1): 3-14.

2) Sato M, Miyazaki T et al. "Quercetin, a bioflavonoid, inhibits the induction of interleukin 8 monocyte chemoattractant protein-1 expression by tumor necrosis factor alpha in cultured human synovial cells. J Rheumatol, 1997; 24:1680-1684.

3) Jobin C, Bradham C et al. "Curcumin blocks cytokine-mediated NF-kappa-B actaivation and proinflammatory gene expression by inhibiting inhibiting factor I-kappa B kinase activity. J Immunol, 1999; 163: 3474-3483.

4) Wang MJ, Huang HM, Hsieh SJ, Jeng KC, Kuo JS. " Resveratrol inhibits interleukin-6 production in cortical mixed glial cells under hypoxia/hypoglycemia followed by reoxygenation." J Neuroimmunol 2001 Jan 1;112(1-2):28-34

[sUper GeNius]

I've been having a minor flare up for the last couple of weeks. A bit of transient dizziness, unusual sensations in head and other places, like a wrist, at the very same time, and slight balance issues.

I've been trying to snuff it like I usually do with high doses of curcumin with piperine. Seems a bit resistant this time, but then again, before curcumin, I've seen this thing progress like you wouldn't believe.

I'd be very interested if you discover any information regarding doses, possible synergy, or possible interference between t-res, curcumin, and any other substances that we all commonly take.

My concern is, that if I am truly have demylenating effects, even though it seems to be progressing slowly, the effects might be cumulative and irreversible.

Hope your friend finds relief.

Edited by FuLL meMbeR, 11 August 2008 - 05:00 AM.

[krillin]

I've been having a minor flare up for the last couple of weeks. A bit of transient dizziness, unusual sensations in head and other places, like a wrist, at the very same time, and slight balance issues.

I've been trying to snuff it like I usually do with high doses of curcumin with piperine. Seems a bit resistant this time, but then again, before curcumin, I've seen this thing progress like you wouldn't believe.

I'd be very interested if you discover any information regarding doses, possible synergy, or possible interference between t-res, curcumin, and any other substances that we all commonly take.

My concern is, that if I am truly have demylenating effects, even though it seems to be progressing slowly, the effects might be cumulative and irreversible.

Hope your friend finds relief.

Like quercetin and luteolin, curcumin induces UGT1A1 which hits resveratrol. No one has to my knowledge reported any interactions yet, but without Maxwatt's toe we'd still think quercetin and luteolin were good resveratrol synergists.

Have you tried low-dose naltrexone yet?

Biol Pharm Bull. 2006 Jul;29(7):1476-9.
Turmeric and curcumin modulate the conjugation of 1-naphthol in Caco-2 cells.
Naganuma M, Saruwatari A, Okamura S, Tamura H.
Kyoritsu University of Pharmacy, Tokyo, Japan.

Turmeric, the powdered dry rhizome of the Curcuma longa plant, and curcumin, the major anti-oxidant constituent of turmeric, have been shown to possess chemopreventive activity. To elucidate the possible interaction of turmeric and curcumin with conjugation reactions, which in many cases are involved in the activation of procarcinogens, we measured their effects in the conjugation of 1-naphthol in Caco-2 cells, a human colon carcinoma cell line, within a 24 h period. Turmeric exhibits inhibitory activity toward both sulfo- and glucuronosyl conjugations of 1-naphthol at approximately the same levels (IC(50)=0.24 and 0.29 mg/ml, respectively). Curcumin inhibits sulfo-conjugation at lower concentrations (IC(50)=9.7 microg/ml), but only showed weak inhibition toward glucuronosyl conjugation of 1-naphthol in Caco-2 cells. In addition, turmeric was found to strongly inhibit in vitro phenol sulfotransferase (SULT) activity and demonstrate moderate inhibitory properties against UDP-glucuronosyl transferase (UGT) activity in Caco-2 cells (IC(50)=0.17 mg/ml and 0.62 mg/ml, respectively). Curcumin also strongly inhibits in vitro phenol sulfotransferase activity with an IC(50) of 2.4 microg/ml. Moreover, and in contrast to the moderate inhibition of UGT activity by turmeric and curcumin, both induce the expression of the UGT1A1 and UGT1A6 genes, revealed by real-time PCR analysis. These findings are indicative of a possible interaction of both turmeric and curcumin with conjugation reactions in the human intestinal tract and colon. This in turn may affect the bioavailability of therapeutic drugs and toxicity levels of environmental chemicals, particularly procarcinogens.

PMID: 16819192

[sUper GeNius]

I've been having a minor flare up for the last couple of weeks. A bit of transient dizziness, unusual sensations in head and other places, like a wrist, at the very same time, and slight balance issues.

I've been trying to snuff it like I usually do with high doses of curcumin with piperine. Seems a bit resistant this time, but then again, before curcumin, I've seen this thing progress like you wouldn't believe.

I'd be very interested if you discover any information regarding doses, possible synergy, or possible interference between t-res, curcumin, and any other substances that we all commonly take.

My concern is, that if I am truly have demylenating effects, even though it seems to be progressing slowly, the effects might be cumulative and irreversible.

Hope your friend finds relief.

Would like to add that my symptoms flared up a bit when I temporarily discontinued my 24 hr IF. Now that I've started it again, I feel better and have more energy. You might want to recommend to your MS friend some IF.