I think the addition of small doses of Polydatin added to My Resveratrol helped my wife and I lose weight. Maybe PD is a Modulator?
Takes off pounds but does this effect continue?
I do not know the answer.
This is all Anecdotal evidence of course.
I added 25 mg of PD to our regiment for a second trial.
Purchased 200 grams PD from Max Watt years ago and he ran out.
A couple months ago I purchased 200 grams 99% PD from Shanghai.
I am doing 3.25 Mile runs and my wife is doing 4.1 mile runs every other day.
Test at your own risk.
We are human lab rats.
I would be suspicious at that price; polydatin is derived from the same plant, and much the same process, as resveratrol, but with a much lower yield. Not that the quality of the goods is necessarily bad, but it could be from a remaindered lot of 10 or 20 kilos, that a factory made on spec, or has left after filling a larger order. Thus it could be old stock,though not necessarily. Further, resveratrol is partly metabolized in the body to polydatin, which again breaks down into resveratrol. Whether this is helpful or not is moot. We do know combining polydatin with resveratrol results in higher transient blood levels of resveratrol according to measurements performed by one of our members. It might be possible to get the same effect simply by taking a higher dose of resveratrol. Having collected many anectdotal accounts of different variations of dose and combinations of various other ingredients with resveratrol, I've comcluded there is a good deal of individual variability in different individualls' response. This may be due to genetically determined metabolic differences, different efficiencies for the enzymes that metabolize resveratrol and related phytochemicals. I found no advantage to using polydatin, whereas another individual considers it essential. For me there is a sweet spot using luteolin and resveratrol in a 2:1 ratio, another cannot tolerate luteolin. Not many here seem to be that enthusiastic for polydatin, perhaps because the effects overlap resveratrol so much. I think you have to experiment to find what works for you, hopefully with some monitoring tools such as a aglucose meter, scale, something to measure your exercise performance and efficiency. Without some kind of measurment for monitoring, it's easy for wishful thinking and placebo effect to overwhelm reason.
(FWIW. to make resveratrol, the cut roots of Polygonum cuspidatum are fermented before extraction, and this converts polydatin present into resveratrol, thus nearly doubling the yield when the alcohol extraction is performed.)