4 replies to this topic

[Crepulance]

Okay question for all you Ressie afficionados. With all this wonderful hooplah, and results of worms, and mice etc having substantially extended lifespans. Why is it that this latest Dr. Sinclair study said that though it kept the mice very healthy, it didn't increase their lifespan at all. Ummm, isn't this counterintuitive towards EVERYTHING we've been hearing and the reasons we're excited about this? Does anyone have any info to explain??


Crep

[maxwatt]

Okay question for all you Ressie afficionados. With all this wonderful hooplah, and results of worms, and mice etc having substantially extended lifespans. Why is it that this latest Dr. Sinclair study said that though it kept the mice very healthy, it didn't increase their lifespan at all. Ummm, isn't this counterintuitive towards EVERYTHING we've been hearing and the reasons we're excited about this? Does anyone have any info to explain??


Crep

Something as simple as the way their chow was prepared could have caused all the mice to die prematurely. Even the DR group's lifespan was shorter than shown in ad-libidum mice of the same strain in other studies. So I'd say I'd like to see the test done with better-cared for mice. And the resveratrol mice apparently had a better quality of life, in that they were more active and healthier as they aged, than the controls.

[Crepulance]

Well it's possible, but that's a pretty big assumption to make. You should probably give the benefit of the doubt that the mice and treatments were provided in a controlled environment, these weren't highschool kids in their basements. And also, let's say it was something very subtle that effected it, that's still horrible, that means those same subtleties effect it with us, and we're NOT in a controlled environment.

Okay question for all you Ressie afficionados. With all this wonderful hooplah, and results of worms, and mice etc having substantially extended lifespans. Why is it that this latest Dr. Sinclair study said that though it kept the mice very healthy, it didn't increase their lifespan at all. Ummm, isn't this counterintuitive towards EVERYTHING we've been hearing and the reasons we're excited about this? Does anyone have any info to explain??


Crep

Something as simple as the way their chow was prepared could have caused all the mice to die prematurely. Even the DR group's lifespan was shorter than shown in ad-libidum mice of the same strain in other studies. So I'd say I'd like to see the test done with better-cared for mice. And the resveratrol mice apparently had a better quality of life, in that they were more active and healthier as they aged, than the controls.

[maxwatt]

Well it's possible, but that's a pretty big assumption to make. You should probably give the benefit of the doubt that the mice and treatments were provided in a controlled environment, these weren't highschool kids in their basements. And also, let's say it was something very subtle that effected it, that's still horrible, that means those same subtleties effect it with us, and we're NOT in a controlled environment.

Okay question for all you Ressie afficionados. With all this wonderful hooplah, and results of worms, and mice etc having substantially extended lifespans. Why is it that this latest Dr. Sinclair study said that though it kept the mice very healthy, it didn't increase their lifespan at all. Ummm, isn't this counterintuitive towards EVERYTHING we've been hearing and the reasons we're excited about this? Does anyone have any info to explain??


Crep

Something as simple as the way their chow was prepared could have caused all the mice to die prematurely. Even the DR group's lifespan was shorter than shown in ad-libidum mice of the same strain in other studies. So I'd say I'd like to see the test done with better-cared for mice. And the resveratrol mice apparently had a better quality of life, in that they were more active and healthier as they aged, than the controls.

It's not an assumption. The restricted calorie group in Sinclair's study did not live as long as the same strain of mice in other studies, by ther labs, even the ad-libidum fed group. There was something about the lab conditions that vitiates the study. You cannot draw life-span conclusions from it one way or the other. Too bad.

[SearchHorizon]

To me, the most interesting part of the study was that the maximum lifespan was not extended in mice under caloric restriction WHEN the caloric restriction was initiated at mid-life.

However, when mice taking resveratrol AND placed under I/F mid-life, the maximum lifespan of mice were extended by 15%.

To me, that is pretty amazing result.