Many thanks for your helpful reply. Could I summarise to see if I have understood this correctly and not missed anything?
We have some anecodotal evidence from users of this forum that resveratrol exacerbates their rheumatoid arthritis and some more anectodal evidence that resveratrol gives some people joint pain. I wouldn't normally give too much credence to anectodal evidence, but in the case of imminst users, I am inclined to give it some weight.
We have a study that indicates that people with lupus react to histone acetylation and methylation by underexp
ression of SIRT1 rather than upregulation of SIRT1 activity. Without resveratrol being involved.
If I haven't understood this correctly or completely, please say.
On the other hand, we have 5 pubmed studies for a search on 'resveratrol' and 'autoimmune'. Only one is on human subjects and none are particularly well designed or adequately powered. I have linked the two that I thought were most significant.
1: Harikumar KB, Aggarwal BB.
Resveratrol: a multitargeted agent for age-associated chronic diseases.
Cell Cycle. 2008 Apr 15;7(8):1020-35. Epub 2008 Feb 15. Review.
PMID: 18414053 [PubMed - indexed for MEDLINE]
2: Singh NP, Hegde VL, Hofseth LJ, Nagarkatti M, Nagarkatti P.
Resveratrol (trans-3,5,4'-trihydroxystilbene) ameliorates experimental allergic encephalomyelitis, primarily via induction of apoptosis in T cells involving activation of aryl hydrocarbon receptor and estrogen receptor.
Mol Pharmacol. 2007 Dec;72(6):1508-21. Epub 2007 Sep 14.
PMID: 17872969 [PubMed - indexed for MEDLINE]
3: Shindler KS, Ventura E, Rex TS, Elliott P, Rostami A.
Free in PMC
SIRT1 activation confers neuroprotection in experimental optic neuritis.
Invest Ophthalmol Vis Sci. 2007 Aug;48(8):3602-9.
PMID: 17652729 [PubMed - indexed for MEDLINE]
4: Penberthy WT.
Pharmacological targeting of IDO-mediated tolerance for treating autoimmune disease.
Curr Drug Metab. 2007 Apr;8(3):245-66. Review.
PMID: 17430113 [PubMed - indexed for MEDLINE]
5: Yoshida Y, Shioi T, Izumi T.
Free Full Text
Resveratrol ameliorates experimental autoimmune myocarditis.
Circ J. 2007 Mar;71(3):397-404.
PMID: 17322642 [PubMed - indexed for MEDLINE]
This leads me to tentatively conclude that:
Resveratrol might be both good or bad for autoimmune conditions, depending on what autoimmune condition it is. Probably rheumatoid arthritis and lupus bad and myocarditis, neurological and age-related immune dysfunction good.
I would be interested to hear if you and other people would agree with my analysis and whether you and or they can add any more value to it as I don't really feel that it is a particularly useful conclusion to those who have an autoimmune condition yet.
I understood that curcummin was useful, but that taking it orally didn't get enough active ingredient past the liver to really count. Can you provide some links on this so I can learn some more?
Thanks in advance.
Thanks for your post. "A theory behind autoimmunity that is starting to prevail gives the immune system a little more credit..." I am interested to learn more on this. Do you have any links that you could let me have?
Thanks in advance.
Best regards to all,