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L-Arginine and sleep


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#1 chilp

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Posted 28 April 2009 - 04:00 PM


So I have a history of sleep troubles, including problems falling asleep, never feeling refreshed in the morning, feeling tired and waking up once or twice a night.
I have a slight sleep apnea condition but my doctor said according to the sleep lab results that it wasn't significant enough to cause those problems.
I have tried everything form herbal stuff to benzos, including tryptophan/5.htp/phenibut and others, to my unsatisfaction.

The other night ,I was feeling a little anxious, and remembered that I had Arginibne in stock, so I thought why not, as an alternative to Theanine or benzos. I took 1000mg.

And guess what, i woke up the following day completely refreshed and in a good mood. So I decided to pursue the experience and to take 1000mg for the following days.
Let me tell you that it's been a massive success so far, waking up upon alarm call and all.

It seems I haven't read anything about Arginine and sleep, have you guys any idea or clue r experience about that ?
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#2 Thorsten2

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Posted 28 April 2009 - 06:17 PM

Thats great news that's it working for you but I have always found arigine to not really be related to this area. Isn't it a pre-curser to Nitros oxide so it improves blood flow throughout the body? Mother Natures viagra is one description I have read and yes it certainly works in this area! I've always thought of improved blood flow as quite 'stimulating' so don't see how it would relax you? Maybe I'm wrong. Would be interesting to find out more about this.
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#3 simon007

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Posted 28 April 2009 - 06:50 PM

Hi Chilp,

I use Arginine to as a sleeping aid and it work's very well. I take about 5 mg 30 minutes before I go to bed. Arginine stimulates HGH, I think that's the reason it works as a sleeping aid. I'm planning to try citrullina, because it's raises the arginine in the body more than Arginine itself. This is because the liver brakes down Arginine.

Cheers,

Simon
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#4 chilp

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Posted 29 April 2009 - 01:47 PM

Hey-

i found this:

Nitric Oxide levels in the brain indicate sleep

Nitric Oxide and sleep apnea

Need to pull an all-nighter ? Reducing Nitric oxide levels....

L-arginine before sleep
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#5 navyblue

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Posted 12 October 2009 - 07:45 PM

Yup, same here, L-arginine knocks me out cold.
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#6 Thorsten2

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Posted 12 October 2009 - 08:25 PM

Hi Chilp,

I use Arginine to as a sleeping aid and it work's very well. I take about 5 mg 30 minutes before I go to bed. Arginine stimulates HGH, I think that's the reason it works as a sleeping aid. I'm planning to try citrullina, because it's raises the arginine in the body more than Arginine itself. This is because the liver brakes down Arginine.

Cheers,

Simon


5mg?? Jeez it must send you to sleep trying to cut your 500mg tablet down to that level
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#7 Lufega

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Posted 13 October 2009 - 12:23 AM

Actually, you know sometimes you yawn and at the same time you get an erection? Both of those are controlled by nitric oxide release. I've been taking 4 grams Arginine in the AM for a couple of weeks and found that it helps relieve tremors. I've found no studies to back this up but it's working for me. I'm using an arginine/ornithine combo but this has not had that viagra effect on me. I'll try arginine/citrulline next..
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#8 easygoer

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Posted 14 October 2009 - 04:30 AM

Oral treatment with L-lysine and L-arginine reduces anxiety and basal cortisol levels in healthy humans.
Smriga M, Ando T, Akutsu M, Furukawa Y, Miwa K, Morinaga Y.Institute of Life Sciences, Ajimoto Co. Inc, 1-1 Suzuki-cho, 210-8681 Kawasaki-ku, Kawasaki-shi, Japan. miro_smriga@ehq.ajinomoto.com

Dietary supplementation with an essential amino acid L-lysine has been shown to reduce chronic anxiety in humans with low dietary intake of L-lysine. A combination of L-lysine and L-arginine has been documented to normalize hormonal stress responses in humans with high trait anxiety. The present study was carried out in one hundred eight healthy Japanese adults. The aim of study was to find out whether a week-long oral treatment with L-lysine (2.64 g per day) and L-arginine (2.64 g per day) reduces trait and stress-induced state anxiety and basal levels of stress hormones. We confirmed that, without regard to gender, the amino acid treatment significantly reduced both trait anxiety and state anxiety induced by cognitive stress battery. In addition, we found that the treatment with L-lysine and L-arginine decreased the basal levels of salivary cortisol and chromogranin-A (a salivary marker of the sympatho-adrenal system) in male subjects. These results of this double-blind, placebo controlled and randomized study confirm the previous findings in humans and animals and point to a combination of L-lysine and L-arginine as a potentially useful dietary intervention in otherwise healthy humans with high subjective levels of mental stress and anxiety.
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#9 Thorsten2

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Posted 14 October 2009 - 04:36 PM

Oral treatment with L-lysine and L-arginine reduces anxiety and basal cortisol levels in healthy humans.
Smriga M, Ando T, Akutsu M, Furukawa Y, Miwa K, Morinaga Y.Institute of Life Sciences, Ajimoto Co. Inc, 1-1 Suzuki-cho, 210-8681 Kawasaki-ku, Kawasaki-shi, Japan. miro_smriga@ehq.ajinomoto.com

Dietary supplementation with an essential amino acid L-lysine has been shown to reduce chronic anxiety in humans with low dietary intake of L-lysine. A combination of L-lysine and L-arginine has been documented to normalize hormonal stress responses in humans with high trait anxiety. The present study was carried out in one hundred eight healthy Japanese adults. The aim of study was to find out whether a week-long oral treatment with L-lysine (2.64 g per day) and L-arginine (2.64 g per day) reduces trait and stress-induced state anxiety and basal levels of stress hormones. We confirmed that, without regard to gender, the amino acid treatment significantly reduced both trait anxiety and state anxiety induced by cognitive stress battery. In addition, we found that the treatment with L-lysine and L-arginine decreased the basal levels of salivary cortisol and chromogranin-A (a salivary marker of the sympatho-adrenal system) in male subjects. These results of this double-blind, placebo controlled and randomized study confirm the previous findings in humans and animals and point to a combination of L-lysine and L-arginine as a potentially useful dietary intervention in otherwise healthy humans with high subjective levels of mental stress and anxiety.


interesting. I've taken l-arigine for the past couple of nights and it has actually knocked me straight out. This has suprised me. When I purchased it I was looking for the libido qualities but it does seem to help with sleep. The 2 nights I have tried it my mind has been racing plus I've had the expectation of the supplement aiding with my sleep. On both occasions so far it has worked very well although you can never discount placebo.
This case study related to anxiety is very interesting. Is there anyone here who has tried lysine + arigine for anxiety?
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#10 simon007

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Posted 14 October 2009 - 08:13 PM

Hi Chilp,

I use Arginine to as a sleeping aid and it work's very well. I take about 5 mg 30 minutes before I go to bed. Arginine stimulates HGH, I think that's the reason it works as a sleeping aid. I'm planning to try citrullina, because it's raises the arginine in the body more than Arginine itself. This is because the liver brakes down Arginine.

Cheers,

Simon


5mg?? Jeez it must send you to sleep trying to cut your 500mg tablet down to that level

Typo :-) it use to be 5 grams

At the moment I'm using 3 grams Arginine and d 2 gram Citulline, still works very well..

Cheers,

Simon
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#11 wolfeye

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Posted 15 October 2009 - 04:32 PM

Growth hormone, arginine and exercise.
Recent studies have shown that resting growth hormone responses increase with oral ingestion of L-arginine and the dose range is 5-9 g of arginine. Within this range there is a dose-dependent increase and higher doses are not well tolerated. Most studies using oral arginine have shown that arginine alone increases the resting growth hormone levels at least 100%, while exercise can increase growth hormone levels by 300-500%. The combination of oral arginine plus exercise attenuates the growth hormone response, however, and only increases growth hormone levels by around 200% compared to resting levels. SUMMARY: Exercise is a very potent stimulator of growth hormone release and there is considerable research documenting the dramatic growth hormone rise. At rest oral L-arginine ingestion will enhance the growth hormone response and the combination of arginine plus exercise increases growth hormone, but this increase may be less than seen with exercise alone. This diminished response is seen in both in both younger and older individuals.


http://www.ncbi.nlm....pubmed/18090659

Edited by Wolf-Eye, 15 October 2009 - 04:33 PM.

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#12 KimberCT

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Posted 15 October 2009 - 04:48 PM

Actually, you know sometimes you yawn and at the same time you get an erection?

Hahahaha, um... no.  ;)


I've been taking 4 grams Arginine in the AM for a couple of weeks and found that it helps relieve tremors. I've found no studies to back this up but it's working for me. I'm using an arginine/ornithine combo but this has not had that viagra effect on me.



Tremors... interesting.  Do you have essential tremor? I haven't tried arginine for this, but I can attest to the viagra effect.
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#13 wolfeye

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Posted 16 October 2009 - 12:11 PM


Central L-arginine reduced stress responses are mediated by L-ornithine in neonatal chicks.


Recently, we observed that central administration of L-arginine attenuated stress responses in neonatal chicks, but the contribution of nitric oxide (NO) to this response was minimal. The sedative and hypnotic effects of L-arginine may be due to L-arginine itself and/or its metabolites, excluding NO. To clarify the mechanism, the effect of intracerebroventricular (i.c.v.) injection of L-arginine metabolites on behavior under social separation stress was investigated. The i.c.v. injection of agmatine, a guanidino metabolite of L-arginine, had no effect during a 10 min behavioral test. In contrast, the i.c.v. injection of L-ornithine clearly attenuated the stress response in a dose-dependent manner, and induced sleep-like behavior. The L-ornithine concentration in the telencephalon and diencephalon increased following the i.c.v. injection of L-arginine. In addition, several free amino acids including L-alanine, glycine, L-proline and L-glutamic acid concentrations increased in the telencephalon. In conclusion, it appears that L-ornithine, produced by arginase from L-arginine in the brain, plays an important role in the sedative and hypnotic effects of L-arginine observed during a stress response. In addition, several other amino acids having a sedative effect might partly participate in the sedative and hypnotic effects of L-arginine.


http://www.ncbi.nlm....Pubmed_RVDocSum

Edited by Wolf-Eye, 16 October 2009 - 12:11 PM.

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#14 matter_of_time

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Posted 16 October 2009 - 02:47 PM

You can try Citruline, it raises arginine levels more than arginine does
http://www.ncbi.nlm....3?dopt=Abstract
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#15 Ahab Blutarski

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Posted 06 April 2010 - 09:59 AM

Thanks for posting. I've hadn't slept fully through the night in years, years, years. L-Arginine in this area was a complete surprize. Thank you for your post. I just woke up and decided to google Arginine and sleep to see if anyone else had similar experience.
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#16 Logan

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Posted 07 April 2010 - 07:53 PM

Thanks for posting. I've hadn't slept fully through the night in years, years, years. L-Arginine in this area was a complete surprize. Thank you for your post. I just woke up and decided to google Arginine and sleep to see if anyone else had similar experience.


So you have tried Arginine and it did work for you?
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#17 Clarity

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Posted 08 April 2010 - 10:13 AM

Every time I have tried using L-Arginine (as well as L-carnitine) it's not failed to keep me up at night. Always in the form of waking up with adrenaline rushes. I however have weak adrenals, and a small (non-functioning) pituitary tumor. I can't even take the homeopathic versions of either supplement. It however takes a good week on those aminos to develop symptoms. I assumed it was because HGH is released during sleep, and the increased HGH was causing the symptoms. Now I wonder if it was just lowering cortisol too much at night.
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#18 NeuroGuy

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Posted 10 April 2010 - 05:50 PM

Hey, I sent this in a PM to lufega but as he said it may be of interest to others. If you have tremors, you should get an ammonia test done. Tremors can be caused my elevated ammonia (liver cant detox ammonia for whatever reason, blood level rises, body uses glutamic acid to lower it, you find yourself deficient in glutamate/glutathione, and a cascade of other imbalances). This could attribute to arginine relieving your tremors. If you've ever experienced brain fog, "wired but tired", or any spacey symptoms, it would have alot to do with that as well.
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#19 curious_sle

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Posted 12 April 2010 - 08:36 PM

Hm, tried it in the last few days at 1000mg and 3000mg and 5000mg and no positive) effect on sleeps alas... :-(
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#20 Joepharm84

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Posted 19 March 2012 - 11:09 PM

Very interesting! I have always had tremors and just attributed it to anxiety. I feel brain fog and wired but tired and have had high ammonia levels in urine and at one stage abnormal liver function blood tests. I will give arginine a try...does anyone know if taking lysine competes with the benefits of arginine or is it synergistic?
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