Hi nancyd,
First Longevinex contains IP6 which has more issues regarding anemia than resveratrol:
From Wikipedia with references:
http://en.wikipedia....iki/Phytic_acid(IP6) Phytic acid is a strong chelator of important minerals such as calcium, magnesium, iron, and zinc, and can therefore contribute to mineral deficiencies in people whose diets rely on these foods for their mineral intake, such as those in developing countries.[6][7] It also acts as an acid, chelating the vitamin niacin, which is basic, causing the condition known as pellagra. [8] In this way, it is an anti-nutrient, despite it's theraputic effects (see below) which simultaneously make it a (phyto)-nutrient.[1] For people with a particularly low intake of essential minerals, especially young children and those in developing countries, this effect can be undesirable.
It almost appears that Longevinex is throwing resveratrol under the bus, instead of IP6, which apparently has the issues as a strong chelator, and bad for some children and anemics. Why this kind of marketing? Maybe someone can correct me on this, but I can only assume he is doing it to protect his sales, or from bleeding customers to other supplement providers who offer more resveratrol at better prices.
Now, about Resveratrol and Collagen:
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Take some time to learn about Collagen if you are a member:
http://www.medscape....warticle/423231Here is an abstract, regarding too much or too little collagen:
http://cardiovascres...t/full/41/2/376So what does Resveratrol do?
====================
It seems to limit it in stroke prone rats, to protect them:
http://www.sciencedi...af2f7705fb2fb54At what dose?
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Here it states that it was in a non-dose dependent manner, which suggests that mega-doses are not issues:
http://www2.hcmuaf.e...Resveratrol.pdfThe
most accepted mechanism of cardioprotection by resveratrol is
the inhibition of platelet aggregation (Bhat and others 2001a).
Platelets are cells without nuclei that are made in the bone marrow
and function to stop bleeding via aggregation at the wound
site. Platelets can be activated by several different factors, including
adenosine diphosphate (ADP), collagen, and thrombin.
When activated platelets change morphology they aggregate and
seal damaged blood vessels. Excessive aggregation can lead to the
development of cardiovascular disease. Pretreatment of platelets
with resveratrol has been shown to inhibit lipopolysaccharide
(LPS) and LPS + thrombin-stimulated platelet adhesion to collagen
and fibrinogen in a non-dose-dependent manner (Olas and
others 2002). Using in vitro and in vivo models,Wang and others
(2002) have demonstrated that resveratrol inhibits ADP, collagen,
and thrombin-stimulated human platelet aggregation in vitro. Furthermore,
rabbits receiving resveratrol supplementation had reduced
rates of platelet aggregation when fed a high cholesterol
diet. The prevention of calcium influx through the stored operated
calcium channels has been suggested as a target for resveratrol
in the inhibition of thrombin-induced platelet aggregation
(Dobrydneva and others 1999).
Again, take the Longevinex marketing with a grain of salt.
At this point I don't see the issue, and there are no studies that I have read stating that resveratrol reduced too much collagen, and has caused issues.
A
Edited by Anthony_Loera, 20 May 2009 - 02:13 PM.