3 replies to this topic

[ppp]

I am thinking of adding quercetin to a twice daily dose of curcumin, resveratrol and omega-3's. From what I've gleaned on pubmed these should all synergise. What kind of dosage should one look at for quercetin? Is a higher dose better or worse than a low dose? Anyone have advice on this?

The curcumin dose is 1.5g of nano-curcumin, resveratrol is 250 mg RevGenetics LiCaps and the fish oils are a high dose (400mg EPA, 200mg DHA).

Thanks.

[ppp]

ppp, on 9-Jun 2009, 07:28 AM, said:

I am thinking of adding quercetin to a twice daily dose of curcumin, resveratrol and omega-3's. From what I've gleaned on pubmed these should all synergise. What kind of dosage should one look at for quercetin? Is a higher dose better or worse than a low dose? Anyone have advice on this?

The curcumin dose is 1.5g of nano-curcumin, resveratrol is 250 mg RevGenetics LiCaps and the fish oils are a high dose (400mg EPA, 200mg DHA).

Thanks.

While researching I found this paper, which looks pretty interesting and adds weight to the res + quercetin argument:

Quote

Resveratrol and quercetin cooperate to induce senescence-like growth arrest in C6 rat glioma cells.
   Zamin LLFilippi-Chiela ECDillenburg-Pilla PHorn FSalbego CLenz G.
    Biophysics Department, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.

    Glioma  is the most frequent and malignant primary human brain tumor with  dismal prognosis despite multimodal therapy. Resveratrol and quercetin,  two structurally related and naturally occurring polyphenols, are  proposed to have anticancer effects. We report here that resveratrol  and quercetin decreased the cell number in four glioma cell lines but  not in rat astrocytes. Low doses of resveratrol (10 microM) or  quercetin (25 microM) separately had no effect on apoptosis induction,  but had a strong effect on caspase 3/7 activation when administered  together. Western blot analyses showed that resveratrol (10 microM) and  quercetin (25 microM) caused a reduction in phosphorylation of Akt, but  this reduction was not sufficient by itself to mediate the effects of  these polyphenols. Most important, resveratrol and quercetin  chronically administered presented a strong synergism in inducing  senescence-like growth arrest. These results suggest that the  combination of polyphenols can potentialize their antitumoral activity,  thereby reducing the therapeutic concentration needed for glioma  treatment. (Cancer Sci 2009).

PMID: 19496785 [PubMed - as supplied by publisher]

[zorba990]

ppp, on 9-Jun 2009, 01:28 AM, said:

I am thinking of adding quercetin to a twice daily dose of curcumin, resveratrol and omega-3's. From what I've gleaned on pubmed these should all synergise. What kind of dosage should one look at for quercetin? Is a higher dose better or worse than a low dose? Anyone have advice on this?

The curcumin dose is 1.5g of nano-curcumin, resveratrol is 250 mg RevGenetics LiCaps and the fish oils are a high dose (400mg EPA, 200mg DHA).

Thanks.

What brand nano curcurmin?  I'm currently using Rutin.

[ppp]

zorba990, on 11-Jun 2009, 01:34 AM, said:

ppp, on 9-Jun 2009, 01:28 AM, said:

I am thinking of adding quercetin to a twice daily dose of curcumin, resveratrol and omega-3's. From what I've gleaned on pubmed these should all synergise. What kind of dosage should one look at for quercetin? Is a higher dose better or worse than a low dose? Anyone have advice on this?

The curcumin dose is 1.5g of nano-curcumin, resveratrol is 250 mg RevGenetics LiCaps and the fish oils are a high dose (400mg EPA, 200mg DHA).

Thanks.

What brand nano curcurmin?  I'm currently using Rutin.

LongVida, by Verdure Sciences.