If you've read some of the excellant works of Dr. Dilman, he clearly explains that increasing hypothalamic neurotransmitters to youthful levels can remove some effects of ageing. AD drugs and many psychedelics have an endocrinal impact. TCAs can increase melatonin synthesis (pineal grafts can even reverse menopause) Serotonin antagonists (Mianserin(Bolvidon), Mirtazapine(Remeron), aglometerine) have already shown to extend lives in worms. Chronic AD's reduce cortisol and this may increase lipespans. Lithium (and valproate and many anti-epileptics) and SSRI's and serotonin1A agonists (2A/2C antagonists) have robust neuroprotective and neurogenic effects, Lithium in particular inspite of a mood darkening "stabilising" effect; some people even take a low-dose Lithium. Of course Selegiline has undoubtable pro-longevity effects Phenytoin and Tianeptine(Stablon) reverse stress injury to the brain. There is no systematic study of AD's in life-extension, yet agents that increase lifespans are often antidepressive. So nature may want us to live "happy" ever after. I've wondered for long that we are overlooking AD's for LE. If you are optimistic do name some antidepressants that you think would lifespans, cite studies and being pragmatic name only AD's used or in trials to be used. Somewhat over-prescribed in cancer too, millions today have been taking ADs (antidepressants) for over a decade now!
LongeCity . Advocacy & Research for Unlimited Lifespans