11 replies to this topic

[ajnast4r]

original thread

current suggestions are folinic acid and methylfolate... perhaps even plain folic acid. does anyone have any reasons why?

my only concert about methylfolate is that we could be ingesting much much higher amounts of methylfolate than would be normally converted from food folate of folic acid. does anyone know how much ends up as mf?

[Blue]

Some interesting manufacturer claims:
http://www.cerefolin...m/Lmethylfolate

[Pike]

wouldn't 5-mthf be super expensive compared to good old folic acid? i'm sure that the idea sounds nice, but when it comes to b-vitamins, folic acid is probably on my lower list of concerns seeing as so many flour/grain products come pre-fortified with folic acid.

[shazam]

My choice would be folinic acid, as folic acid is sythentic folate, but folinic acid is found naturally in food just by itself. There are probably other (minor) benefits to it over folic acid, and they're probably pretty similar.

www.bioconcepts.com.au/pdf/products/DVPI/folinic_acid.pdf Manufacturer claims regarding folinic, citing several studies. It also will probably not have the potential legal issues and large expense associated with it in addition to being more natural than folic acid.

[pycnogenol]

Yes. My choice is L-methylfolate 400 micrograms daily.

Edited by pycnogenol, 12 November 2009 - 11:29 PM.

[shazam]

Yes. My choice is L-methylfolate 400 micrograms daily.

That's a pretty aggressive dose.

If the legal and expense issues are not out of line, I'd be good with the same form at 100-200mg.

If they are, folinic acid will be fine.

[pycnogenol]

Yes. My choice is L-methylfolate 400 micrograms daily.

That's a pretty aggressive dose.

If the legal and expense issues are not out of line, I'd be good with the same form at 100-200mg.

If they are, folinic acid will be fine.

Aggressive dose? How so? I take 400 micrograms [mcg] which is 100% of the RDA.

[ajnast4r]

Yes. My choice is L-methylfolate 400 micrograms daily.

That's a pretty aggressive dose.

If the legal and expense issues are not out of line, I'd be good with the same form at 100-200mg.

If they are, folinic acid will be fine.

Aggressive dose? How so? I take 400 micrograms [mcg] which is 100% of the RDA.

400mcg is the rda for food folate... the rda for synthetic folic acid is 200mcg. methylfolate is likely significantly more potent than folic acid so who knows how that works out in folate equivalents.

[Mind]

400mcg is the rda for food folate... the rda for synthetic folic acid is 200mcg. methylfolate is likely significantly more potent than folic acid so who knows how that works out in folate equivalents.

Maybe we should find out.

[rwac]

If the legal and expense issues are not out of line, I'd be good with the same form at 100-200mg.

The legal issues are a potential problem.

There must be some reason there are comparatively few methylfolate supplements out there.

[Tithonus]

If the legal and expense issues are not out of line, I'd be good with the same form at 100-200mg.

The legal issues are a potential problem.

There must be some reason there are comparatively few methylfolate supplements out there.

Having access to several supplement companies, I asked them about this. It seems it's mostly just about profitability. It's far more profitable to sell pharmacies and go via the drug channel than it is to sell it as a nutritional supplement.

I would back folinic acid, as it bypasses a few steps in the conversion process to L-Methylfolate.

[maxwatt]

If the legal and expense issues are not out of line, I'd be good with the same form at 100-200mg.

The legal issues are a potential problem.

There must be some reason there are comparatively few methylfolate supplements out there.

Having access to several supplement companies, I asked them about this. It seems it's mostly just about profitability. It's far more profitable to sell pharmacies and go via the drug channel than it is to sell it as a nutritional supplement.

I would back folinic acid, as it bypasses a few steps in the conversion process to L-Methylfolate.

Those with the MTHFR genetic polymorphism cannot convert folic acid to methyl folate efficiently, and do not benefit from folic acid supplements.