44 replies to this topic

[hamishm00]

P5P is inferior to pyridoxamine for glycation. Yes it is superior for lipid glycation.

Wafker reckons "While the B6 vitamin activity of all its vitamers is comparable since the body contains interconversion enzymes, the activity of [Pyridoxamine] as an amino acid or protein glycation inhibitor has been shown to be superior to that of [pyridoxine], [pyridoxal] and [P5P]"

[kenj]

Pyridoxamine is now classified as a drug due to one of its active ingredients, thus it is no longer available as a supplement.

Yes, well Pyridoxamine is the active ingredient. ;-) But we know the FDA's position as it has been discussed here (it is not yet an approved drug BTW). Also can be read in this LEF article:

http://www.lef.org/m...doxamine_01.htm


But you can still find it until sold out at LEF. I got my last 2 bottles from them just a few weeks ago.

Edit:typos

Frank,

when does yours expire? Thanks.

Well, the last ones I recieved from LEF has a 'for optimal potency use by 06/11' print on them (previous batch was 01/11), so might keep a few in the fridge/freezer for now...

Edited by kenj, 10 March 2010 - 01:13 PM.

[pycnogenol]

4/2010 - iHerb is now back selling pyridoxamine

http://www.iherb.com...Caps/14452?at=0

[Hedrock]

For anti-glycation, I take
p5p
b12 methylcobalamin (my diet is low in meat)
and loooooooots of tea

Did you mean B6 or B1? B12 is important but I never heard of anti-glycation effects.

I have a diet free from meat and against glycation I take:
- Carnosine (the best glycation inhibitor for it's ability to withdraw glycated proteines from the body!)
- Pyridoxamine
- Benfotiamine
- Aminoguanidine
- EGCG
- Quercetin
- 5 types of Ginseng
- Pure licorice
- Emodin (in my RESV pills)
- Sometimes carnitine drink after sports

Natural substances like ginseng or (pure/sugarfree) licorice can be very good glycation inhibitors, sometimes better than the isolated chemicals.

Carnosine is a must!

Edited by Hedrock, 21 April 2010 - 06:18 PM.

[pycnogenol]

I have a diet free from meat and against glycation I take:

- Aminoguanidine

How much Aminoguanidine do you take?

[hamishm00]

and where the hell do you get it?

[N.T.M.]

Carnosine is a must!

#1 antiglycation supp out there IMO.

I take 1500 mg/day.

4/2010 - iHerb is now back selling pyridoxamine

http://www.iherb.com...Caps/14452?at=0

THANK YOU

Edited by N.T.M., 22 April 2010 - 08:12 AM.

[normalizing]

this one; http://www.ncbi.nlm....les/PMC4877549/

Sildenafil Ameliorates Advanced Glycation End Products-Induced Mitochondrial Dysfunction in HT-22 Hippocampal Neuronal Cells

 

and this one; http://www.iherb.com...Caps/14452?at=0 says discontinued, anyone has an idea why?

[2tender]

R-lipoic acid combined with RHDLA(only one company makes this) combined with palm oil tocotrienols has good effect. As always, need to cycle them (regular brief off-periods). I can't imagine using Viagra regularly, unless they were micro-dosing.

[normalizing]

ive used viagra as study aid and no, you dont get errections all of sudden out of nothing. it has to be stimulation so it wouldnt be a problem to experiment with it regular doses.

 

and to ask, what exactly is RHDLA

[2tender]

Sorry it's RDHLA. It's the antioxidant that R-lipoic acid converts to. See Geronova.com for more.

[Nate-2004]

 

Carnosine is a must!

#1 antiglycation supp out there IMO.

I take 1500 mg/day.

 

 

I realize I'm replying to an old post from more than 6 years ago but carnosine has an incredibly short half-life. The timing would have to be perfect if it even actually prevents cross-links. It's apparently out of your system in 90 mins. Let's say I eat a bowl of ice cream, when would glycation happen and at what point would I take the pill?

[normalizing]

nate, its short half life is much better than no life at all considering not much else is widely available to counteract glycation. what we can is what we do, its summary of advancement in this field, still short

[2tender]

Agreed, , we are in the state of oxidation twenty-four, seven, since birth. Any neutralization of oxidation, no matter how brief is better than none at all. Supplementing and exercise work.

[TheFountain]

Guys, how is Lifelink still able to sell Pyradoxamine? 

 

I added some to my cart and am about to order some.