ebselen (other name is harmokisane) is one of the peroxynitrite (ONOO) scavengers.
Do you know if it available commercially?
Also I'm looking for Nitric Oxide Synthase inhibitor (NOS inhibitor).
L-NAME [N(G)-nitro-L-arginine methyl ester] is one of them, but unfortunately doesn't available commercially.
Do you know of NOS inhibitor that is available commercially?
I want to take NOS inhibitor, because:
1. To decrease production of peroxynitrite and nitrative ( nitrosative ) stress and inflammation.
because: NO + superoxide -->peroxynitrite--> inflammation, DNA damage
L-Arginine Enhances Nitrative Stress And Exacerbates TNF-Alpha Toxicity To Human Endothelial Cells In Culture: prevention by propofol.
A Novel Mechanism, Uniquely Dependent on Mitochondrial Calcium Accumulation, Whereby Peroxynitrite Promotes Formation of Superoxide/Hydrogen Peroxide and the Ensuing Strand Scission of Genomic DNA.
2. NOS inhibition has anti-depressant properties:
stress -->increase NO--> increase nitrosylation of TPH2 (the enzyme that synthesize serotonin)-->less serotonin is synthesized-->depression, sleep problems
A role for serotonin in the antidepressant activity of NG-Nitro-L-arginine, in the rat forced swimming test.
The selective serotonin reuptake inhibitor fluoxetine reduces striatal in vivo levels of voltammetric nitric oxide (NO): A feature of its antidepressant activity?
http://www.ncbi.nlm....Pubmed_RVDocSum
http://www.ncbi.nlm....Pubmed_RVDocSum
eNOS gene deletion restores blood-brain barrier integrity and attenuates neurodegeneration in the thiamine-deficient mouse brain.
http://www.ncbi..nlm...t_uids=12668047
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Also there is another kind of peroxynitrite scavenge- Porphyrins (metalloporphyrin) are peroxynitrite decomposition catalysts.
Do you know if one of them is available commercially?
http://www.ncbi.nlm.nih.gov/pubmed/18395709?ordinalpos=247&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
http://www.ncbi.nlm.nih.gov/pubmed/18684473?ordinalpos=106&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
http://www.ncbi.nlm.nih.gov/pubmed/18591189?ordinalpos=148&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
iron porphyrin=FeTPPS
Edited by rotem, 12 February 2010 - 01:09 PM.