Jay, on Apr 16 2010, 02:20 PM, said:
Anybody give much thought to the fact that fish oil pills have a lot of elongated n-3's (EPA and DHA) while most dietary n-6 consumption is linoleic acid, which requires elongation by D6D to become arachidonic acid. Many things can interfere with that elongation process (CLA to name one that I know applies to me), with the result that little linoleic acid may get converted to arachidonic acid. My dietary intake of arachidonic acid is almost entirely from eggs and is probably less than my dietary intake of EPA and DHA. I'm not sure that's a good thing.
As I work through MR's doubts about fish oil, I realize that over-consumption of elongated n-3s is at the root of his concerns. It's all speculation and his is better than mine. However, consuming vegetabel oils should satisfy his concerns and that doesn't seem to work so well in actual people.
Let's look at what successful people ate: the Inuit (fish, seal, caribou), Kitavans (sweet potatoes, coconut, fish, fruit), Tokelauans (coconut, fish, fruit), Masai (cow), Lyon Cohort (olive oil, whole grains, pasta, fish, lean meat, fruits and vegetables). It seems likely that all these people got more elongated n-3s than ALA (except maybe the Lyon cohort) and more elongated n-3s than elongated n-6s.
I think my (i), (ii), (iii) thing is a pretty good target. It might make sense to try to reduce fish oil pill consumption as much as possible, relying more on grass fed dairy, omega 3 eggs, olive oil, and perhaps less than 1 gram from fish oil pills, taken with vit E or some other fat soluble antioxidant.
Edited by Jay, 16 April 2010 - 07:54 PM.