You can order naltrexone on alldaychemist, I'm trying to obtain a legitimate prescription from a psychiatrist, but my next appointment isn't until the end of the month. The tablets on the site are 50mg, and come in packs of 10. I'm ordering 3 packs, and will be dividing each tablet into 8 doses each, so it'll last me for 240 doses. You don't need a high dose of this stuff to cure OCD and depersonalization. The price is more than worth it, you'll be getting your life and sanity back. It's literally a miracle drug, and I feel better now than ever before. You'll feel vigilant, intelligent, with an improved memory, less anxiety and depression, just all around better. Take my word on it.
-What do you think it would do if a normal person took naloxone/naltrexone (nootropic value)? Would they get extra mental clarity + speed of thinking?
-Do you feel a noticable difference between using nalaxone vs naltrexone?
- Also, this is from wikipedia: " Naloxone is a μ-opioid receptor competitive antagonist, and its rapid blockade of those receptors often produces rapid onset of withdrawal symptoms". Did you experience any withdrawls or anything like that? It would make sense if withdrawls do happen when you first start taking naloxone because of upregulation happening just like the side effects of memantine when you first start taking it and you get brainfog.
- How long do the effects last for? Do you have to redose every hour/day/weeek?
- Since your blocking opioid receptors (antagonism), wouldn't they upregulate and become more sensitive which could possibly make you super sensitive to opiates or something?
- Wouldn't it be better to use nalorphine instead since it is longer acting than naloxone? Although it is a mu-antagonist and kappa agonist, wouldn't that be counterproductive since you said kappa-receptor antagonism is what treated your derealization?
- You also seem to be talking about naloxone and naltrexone, what is the difference between them (pros/cons) in your experience? I think since naltrexone has a higher affinity for k-receptors (antagonism), it should be more effective than naloxone.
Well from what other people who have used naltrexone have reported, it's caused an increase in alertness, energy, memory, and mood..I can definitely attest to the fact that naloxone has done that for me, I haven't tried naltrexone yet but I just ordered some, it should arrive sometime this or next week. Naloxone has a very short half-life (1-1.5 hours), while naltrexone has a 4 hour half life..so redosing on naloxone is necessary every few hours for me to keep the effects active. I can only assume that naltrexone will be even more effective for me since it's longer lasting and has a higher affinity to the k-opioid receptors than naloxone.
From what I've researched, it more than likely will cause hypersensitivity for opiates in me in the long run, but I have no problem with that..I don't plan on using opiates again, naloxone completely blocks the normal drug-seeking behavior that is hardwired into my brain. The idea of getting high or altered doesn't even occur to me while "under the influence" of naloxone..and it's given me the ability to focus on tasks at hand and increase my ability to pay attention better than anything else I've ever taken. I'm actually cutting out all stimulants and depressants, including caffeine..I get all the energy and focus I need from simply blocking my kappa-receptors..it produces such a remarkable and profound effect in my ability to think, I seriously don't understand why this drug isn't being used as a main-line treatment for OCD, ADHD, depression, and anxiety. It effectively destroys all of those at once, it's a miracle!!