6 replies to this topic

[mclaren779]

Hello I have read a couple threads concerning magnesium-L-threonate's nootropic effects.And ways of having mag. pass the blood brain barrier.

I have a question using certain forms of liquid mag.applied to the skin with dmso.any studies?

Anyone tried this? any suggestions or ideas are appreciated. Anyone know of any sources of magnesium-L-threonate.?

[babcock]

Hello I have read a couple threads concerning magnesium-L-threonate's nootropic effects.And ways of having mag. pass the blood brain barrier.

I have a question using certain forms of liquid mag.applied to the skin with dmso.any studies?

Anyone tried this? any suggestions or ideas are appreciated. Anyone know of any sources of magnesium-L-threonate.?

I've never heard or read of application to the dermis but I know that magnesium-L-theronate is being patented by the handful of scientists who discovered it allowed mag to cross the BBB.

More info on this thread here: http://www.imminst.o...mp;hl=Magnesium

There's also another thread around here somewhere where someone posted the scientists were looking to patent the chemical.

[Lufega]

Magnesium and sulphate are both absorbed via the skin which leads to imply that the combination would do the same. (at least in vitro).

Permeability of human skin to selected anions and cations--in vitro studies.
Laudańska H, Lemancewicz A, Kretowska M, Reduta T, Laudański T.

Department of Dermatology, Bialystok Medical University, Poland.

Abstract

Among the many factors influencing the human body every day, metal cations and anions are some of the most important and are constantly present in atmospheric fallout. Some of them such as sulfate or nitrate anions along with different detergents may cause pathological changes within the skin. The aim of this study was to estimate whether sulfate (SO4(2-)) and nitrate anions (NO3-) as well as metal cations, magnesium (Mg2+) and calcium (Ca2+) are able to pass through isolated patches of human skin and to investigate the dynamics of ion diffusion. Concentrations of the substances corresponded to those observed in the atmospheric fallout in two regions of Poland with low (Białowieza) and high (Katowice) pollution rate. Ion chromatography method was used to determine cations and anions levels. In vitro, we found human skin to be permeable to magnesium and calcium ions as well as sulfate and nitrate anions at concentrations observed in the atmospheric fallout in two regions of Poland having different levels of pollution. Diverse influence of sodium lauryl sulfate (SLS) detergent on the grade of metal ion permeability (acceleration in the first 10 hours of experiment) and anion permeability (lack of SO4(2-) influence) suggest the presence of different routes of ions penetration through the skin. It is also supported by different transportation characteristics of individual ions through the skin over time.

PMID: 15080493 [PubMed - indexed for MEDLINE]

[Lufega]

http://www.epsomsalt...ium_sulfate.pdf

Conclusion:

Bathing in Epsom salts is a safe and easy way to increase sulfate and magnesium levels in the body.

[mclaren779]

Thanks for the replies,


I wonder if there are any studies for helping raising mag. levels in the brain? "ie:crossing the blood brain barrier"

[chrono]

Magnesium and sulphate are both absorbed via the skin which leads to imply that the combination would do the same. (at least in vitro).

Unfortunately, Mg sulfate is largely ineffective at raising brain levels of magnesium, even with large injected dosages. This paper was cited by the threonate study:

Analysis of the brain bioavailability of peripherally administered magnesium sulfate: A study in humans with acute brain injury undergoing prolonged induced hypermagnesemia.
McKee JA, Brewer RP, Macy GE, Phillips-Bute B, Campbell KA, Borel CO, Reynolds JD, Warner DS.

OBJECTIVE: Based on preclinical investigations, magnesium sulfate (MgSO4) has gained interest as a neuroprotective agent. However, the ability of peripherally administered MgSO4 to penetrate the blood-brain barrier is limited in normal brain. The current study measured the passage of intravenously administered Mg into cerebrospinal fluid in patients with brain injury requiring ventricular drainage. DESIGN: A prospective evaluation of the cerebrospinal fluid total and ionized magnesium concentration, [Mg], during sustained hypermagnesemia was performed. SETTING: Neurosciences intensive care unit at a major teaching institution. PATIENTS: Thirty patients with acute brain injury secondary to subarachnoid hemorrhage, traumatic brain injury, primary intracerebral hemorrhage, subdural hematoma, brain tumor, central nervous system infection, or ischemic stroke were studied. INTERVENTIONS: Patients underwent 24 hrs of induced hypermagnesemia during which total and ionized cerebrospinal fluid [Mg] was measured. Serum [Mg] was adjusted to 2.1-2.5 mmol/L. Cerebrospinal fluid [Mg] was measured at baseline, at 12 and 24 hrs after onset of infusion, and at 12 hrs following infusion termination. MEASUREMENTS AND MAIN RESULTS: At baseline, total (1.25 +/- 0.14 mmol/L) and ionized (0.80 +/- 0.10 mmol/L) cerebrospinal fluid [Mg] was greater than serum total (0.92 +/- 0.18 mmol/L) and ionized (0.63 +/- 0.07 mmol/L) [Mg] (p < .05). Total (1.43 +/- 0.13 mmol/L) and ionized (0.89 +/- 0.12 mmol/L) cerebrospinal fluid [Mg] was maximally increased by 15% and 11% relative to baseline, respectively, during induced hypermagnesemia (p < .05). CONCLUSIONS: Hypermagnesemia produced only marginal increases in total and ionized cerebrospinal fluid [Mg]. Regulation of cerebrospinal fluid [Mg] is largely maintained following acute brain injury and limits the brain bioavailability of MgSO4.

PMID: 15753761 [PubMed - indexed for MEDLINE]

[mlt500]

If people are still interested, my partner and I are working to bring Magnesium l-threonate to the US. For more details, see here.

It's a big investment so we're gathering names for an interest list - the more people who sign up, the sooner we will be able to launch, so if you are interested please let your friends know.