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Nootropics Thread Index


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#1 chrono

  • Location:New England

Posted 25 August 2010 - 02:22 PM

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Welcome to the nootropics forum! I hope you enjoy yourself, connect with other enthusiasts, and learn a lot about this exciting new field. Feel free to PM me if you have any questions or concerns about the nootropics subforum! Posted Image

If you're new here, please take a moment to read these few guidelines, and help us maintain the quality of discussion in this forum:


1. The substances and practices we discuss here are highly experimental. We are a community of self-experimenters who share experiences and discuss the neurochemistry of cognition. In many conversations, members will suggest a course of action...but under no circumstances should anything here be construed as authoritative medical advice. Though there is a wealth of helpful information and advice here, it is ultimately your responsibility to research the risks and benefits, and decide what you're comfortable with.

2. All substances affect each individual differently, especially those which work upon the mind. Cognitive enhancement is a fledgeling field, and availability of good studies is the exception, rather than the rule. There is no single answer to what nootropic to take for a given application, and the experiences of others should only be taken as a range of possibilities, which may or may not apply to you.



3. Search before posting. There is a six-year backlog of discussion here. If your question is of a basic nature, then it has almost certainly been discussed before. In light of the two points above (and because you probably won't get many responses if you don't!), please take the time to do a little research and familiarize yourself with the issues at hand.

4. Post in an appropriate thread. If a suitable topic already exists, please post there (even if it's old), rather than making a duplicate thread.

Edited by chrono, 05 November 2011 - 09:09 PM.

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#2 chrono Re: Nootropics Thread Index

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Posted 25 August 2010 - 02:22 PM

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Basic Info

Ten months of research condensed - A total newbies guide to nootropics - Intro on designing a stack, basic recommendations, and new user feedback. NOT a universal stack that will work for everyone.

Did Nootropics work for you? - Some interesting opinions and retrospectives

Spreadsheet of info on Common Nootropics / Productivity Enhancers - User-edited spreadsheet of general drug properties. A good quick reference for effects and dosage ranges, but be aware that it contains many inaccuracies, omissions, and doesn't cover the entire range of experience/adverse effects for these substances.

Full or Empty Stomach



Piracetam

Piracetam research and benefits - Argument about efficacy, lots of studies
Piracetam in Normal, Healthy Humans - Efficacy, studies
Piracetam and other racetams: My own review of several journal article - summary of a few studies

Piracetam efficacy - appreciable effect for you? - many anecdotal reports of dosages and effects
Piracetam micro doses
Validity of Attack Dose/Loading Phase for Piracetam

Strange Piracetam Response - dreams

Best time of day to take choline supps - research about acetylcholine depletion
piracetam without ANY choline source

Piracetam efficacy after 3+ months - tolerance
Piracetam non-responders - complete non-response, brain fog, tolerance
Piracetam Rebound? Side-Effect? - effects of discontinuation
Piracetam safety - long-term users report here - tolerance, discontinuation
Piracetam loses effect after two weeks


Ridiculously large piracetam doses
Piracetam = Intense Energy - hypomania

Adderall/piracetam Thoughts - possible excitotoxicity w/ adderall
Repairing cognition after vyvanse+piracetam excitotoxicity



Aniracetam
Aniracetam vs. Piracetam What's the difference?
Piracetam vs. Aniracetam poll
Is Aniracetam just suppose to be stronger than Piracetam?


Oxiracetam
Aniracetam vs. Oxiracetam vs. Pramiracetam - experiences
Oxiracetam: Sleepy? - mild side effects, a few experiences

Downsides of mega-dosing: [1] [2]


Pramiracetam
11 Studies of Pramiracetam
Pramiracetam: Is is worth the price?
Pramiracetam Any Sources? - outdated source discussion, but some general info too
Pramiracetam - Great so far - experiences

Pramiracetam: Nitric Oxide


Cholinergics

Choline causing depression: [1] [2] [3] [4] [5]

What are all the possible symptoms of acetylcholine overload?

Piracetam irritability related to low carb diet? - dietary influence on acetylcholine levels

ALCAR
Cholinergic Mechanisms of ALCAR (And synergy with Piracetam)
ALCAR Arginate

ALCAR & Free Radical Production - Discussion of necessity of ALA cosupplementation


Alpha-GPC
alpha-GPC empty stomach or with meals?


DMAE
Centrophenoxine vs DMAE


CDP Choline
CDP Choline increases ACh and dopamine receptor densities

Edited by chrono, 20 September 2011 - 01:07 AM.

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#3 chrono Re: Nootropics Thread Index

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Posted 25 August 2010 - 02:23 PM

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Neurogenetic

Benefits - real or illusory - and side effects to stimulating NGF - Lion's Mane mushroom: science, chemistry, products. Some general discussion of NGF.

serotonin receptor regeneration nootropics? - repairing drug-induced damage


Herbs

Shankhpushpi: Convulvulus pluricaulis and Evolvulus alsinoides

Ashwagandha
Ashwagandha - Research Distilled - Abstracts and general discussion
Ashwagandha: the sleeper has awakened - experiences and research

* Saponin molecules in bacopa - research on active molecules, composition

Bacopa
Bacopa monnieri: Anyone else using this?

Best Bacopa brand? - brands, research
Bacopa monnieri and heavy metal toxicity

horrible diarrhea from bacopa
Bacopa issues - GI upset

Bacopa and Fatigue
Does Bacopa make you tired?


Lemon Balm
Melissa officinalis (Lemon balm) mechanism of action - GABAergic effect
Lemon Balm study - experiences
Lemon Balm-Potential Nootropic? - Cognitive effects

Gotu Kola
Gotu Kola (Centella Asiatica) - research and experiences
Why does Gotu Kola make me feel good and bad? - negative experiences


Rhodiola
Rhodiola rosea as a nootropic



Vasodilators
Vasodilators? - General theory
Favorite Vasodilator?


Vinpocetine
Vinpocetine -- Ditch It - counterproductive mechanisms
Serious problem with vinpocetine - blood pressure

Experiences: [1] [2]


Experiences: [1]


Dopaminergics

PEA
1st time phenylethylamine user..... my experience.... - combos, dangers
Phenylalanine vs Phenylethylamine


Tyrosine
L-Tyrosine/NALT
L-Tyrosine = amazing


L-DOPA
Mucana Pruriens? - general
L-DOPA w/ Green Tea (Extract) - COMT/DCC inhibition


Sulbutiamine
Sulbutiamine (Various abstracts) - Theory, some research
The vitamin B analogue--sulbutiamine - research, general info
Sulbutiamine (increased dopamine receptor density) - experiences, dosage, tolerance
sulbutiamine (active ingredient in BioTest's Spike) - dosage, a few papers

Sulbutiamine adverse affects - a few negative experiences

Experiences: [1] [2] [3]




Antidepressants + Anxiolytics

Best one-time supplement for situational anxiety


Bupropion (Wellbutrin)
Wellbutrin/Bupropion contradictions?
Wellbutrin/Bupropion Anticholinerigic


Tianeptine (Stablon)
If only I could dodge Tianeptine side effects


Afobazol
So I've started Afobazol for my anxiety [thorsten]


Agomelatine
Valdoxan/Agomelatine & Melatonin
Regarding Agomelatine...Dosage makes a massive difference!

Lithium (low dose)
Lithium Orotate: Any recent research? Safe at daily low doses?
Found a dosing schedule to minimize "lithium fog"
Lithium Or Deprenyl For Stress Induced Brain Damage?


Beta Blockers
Beta Blockers for Anxiety
Beta Blockers and Cognition - enhancement from stress relief




Stimulants

Long-Term Effects Of Taking Modafinil and AHDH Drugs

Caffeine
Extremely Slow Caffeine Metabolism
Caffeine Anxiety

Best nootropics to eliminate caffeine dependency

Methylphenidate (Ritalin)
All Ritalin users please give input - nootropic combinations

Modafinil
Modafinil: 2008 Reviews
Modafinil Trail - experience, dosing
Experiences with modanifil (modalert)
Modalert -- what are we buying really? - generic quality, dosing

Modafinil = neuroprotective?
How to Potentiate Modafinil - synergy and tolerance

The dark side of modafinil


Experiences: [1]

Sleep
Sleep supplement suggestions
Anything new in dealing with insomnia?
The Mega Sleep Thread - anecdotal recommendations


Melatonin
Melatonin: question - research (effect on endogenous production), experiences
Melatonin...is it really a good idea? - research, experiences
Melatonin: Fountain of Youth - Anti-aging effects
melatonin precursor stimulates BDNF: N-acetylserotonin

Melatonin could hurt memory formation
Melatonin - Detrimental mechanisms

Experiences: [1] [2] [3]
Negative Experiences: [1] [2]





Attention

Procrastination?
Motivation drug?


Diet and Cognition
Brain Supplements for vegetarians & vegans

How does a low-carb diet affect mental performance?

Edited by chrono, 10 October 2011 - 12:40 PM.

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#4 chrono Re: Nootropics Thread Index

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Posted 25 August 2010 - 02:23 PM

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Esoteric Nootropics
Advanced discussions and serious, untested or esoteric substances. If you're new here, these probably are not for you ;)

The search for a safe Alpha7 Nicotnic Receptor Agonist?

Fisetin
Why we havn't heard more about fisetin

Pycnogenol and ADHD
Pycnogenol and verbal fluency


Methylene Blue
* Methylene Blue Experiences
* Methylene Blue Dosing and Products
* Methylene Blue Research
* Methylene Blue and MAO Inhibition



Cannabinoid antagonists for memory encoding?

Tenoten/Proproten - Russian S100 Antibodies (anxiolytic)

Reduction of kynurenic acid shows promise for improving learning



Ampakines
Conclusive evidence that aniracetam is an AMPA modulator

My CX516 log [stargazer]


Hydergine
Hydergine: Health Risks


Acetylcholinesterase Inhibitors (AChEI)

AChEIs (Acetylcholinesterase Inhibitors)/Huperzine A Dangers - Possible disruptions of sleep, memory consolidation, and relationship with AD

Exelon patch - rivastigmine


Huperzine A
Huperzine A - Some basics
Huperzine A: Hypervigiliance? - subjective effects, some papers


Huperzine A and NMDAr antagonism and NGF-secretagoge activity



Nicotinergics

Nefiracetam
Questions about Nootropics - Nefiracetam
Nefiracetam

Nicotine
Nicotine and Vasoconstriction - Research for adverse effects
Nicotine patch for focus - a log - many experiences, effects
Nicotine Patches: Snus a Cheaper Alternative?




NMDA Antagonists

NMDA antagonists for drug tolerance, does it work?

Agmatine, anybody try this one?

Memantine
Treatment of I-ADD - memantine + guanfacine or galantamine
Memantine combined with drugs/supplements OTHER THAN psychostims

Experiences: [1] [2] [3] [4] [5]



Dopaminergics

Dopamine/Serotonin antagonists?

Intrest in lisuride


Piribedil
Trivastal Piribedil New D2/D3 Agonist - research
Trivastal
Trivastal/Piribedil Trial


Deprenyl
Rasagiline for ADD
Selegiline for motivation

PEA+Deprenyl log - potentially harmful combo

MAOI, SSRIs: [1] [2] [3] [4]

Age: [1] [2] [3]


Noradrenergics
increasing norepinephrine

Reboxetine is cool stuff


Peptides

Has anyone tried MemoProve Neuropeptide N-PEP-12

Intranasal insulin

Deltaran (DSIP analogue)

Colostrinin

Scientists develop nasal spray that improves memory - Interleukin-6

Oxytocine


Noopept
NOOPEPT - ??????? Noopept, new nootrope to us, old to Russia [ben - aus]
NOOPEPT Has anyone here ever used it?
*NOOPEPT vs. Cerebrolysin?
*Is Noopept water or fat soluble?
*Just ordered some Noopept...
*NOOPEPT Mega-Dose


Semax
SEMAX ® and Phenylpiracetam (Phenotropyl)
Semax - it may be interesting
Would you buy Semax, if it were available?


Selank
SELANK ® - general discussion
Selank trial [log: medievil]


Cerebrolysin
Cerebrolysin
Cerebrosene = cerebrolysin? - oral delivery, liposomes, CRB composition
Do You Have Questions About Cerbrolysin - some outstanding questions/concerns

Edited by chrono, 25 October 2011 - 09:14 AM.

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#5 chrono Re: Nootropics Thread Index

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Posted 25 August 2010 - 02:23 PM

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Other Topics

Meditation and Hypnosis
best mp3 for permanent stress relief, relaxation

Meditation the Nootropic

Neuro Programmer inquiry
Holosync Mind Stim (EEG training)
iMusic BrainAmp

Electrical Stimulation-IQ-any way to do it at home?

Neuroscience
Synthesis of classical neurotransmitters from amino acids

Converting dosages from animal studies


Research
Methodology in medical research: learn how to better evaluate results


Ethics and Philosophy of Cognitive Enhancement
Anders Sandberg on cognitive enhancement

Edited by chrono, 17 September 2011 - 06:00 PM.

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#6 MrHappy Re: Nootropics Thread Index

  • Location:Australia

Posted 07 October 2011 - 09:34 PM

There was a link to a paper either in this thread or the other big one that had MB distribution in different organs.

MODS: can we get a new MB section, like resveratrol and move the existing MB posts into it? That way we can also create some sticky posts with dosage, etc?
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#7 chrono Re: Nootropics Thread Index

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Posted 07 October 2011 - 10:34 PM

MODS: can we get a new MB section, like resveratrol and move the existing MB posts into it? That way we can also create some sticky posts with dosage, etc?


Hmm, interesting idea, but I doubt it would fly. The higher-ups are fairly cautious about creating new subforums. Despite its promise, I don't think there's enough threads (or research) yet to warrant a dedicated forum.

But the several mega threads do make it difficult to find answers without investing a lot of time (and frankly there's a lot of unnecessary info to wade through, like the way this thread keeps coming back to MAOIs). It would be nice to provide easier access, somehow. Perhaps a thread or longer entry in a thread index with links to the best posts/discussions on research and aspects of usage?
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#8 MrHappy Re: Nootropics Thread Index

  • Location:Australia

Posted 08 October 2011 - 04:26 AM

Hmm.. If that is the case, how about a subsection called 'Research Area - Enter at your own risk' (or similar) and then 'MB', etc under that?

Much faster to browse and easier to organise information.
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#9 Brainbox Re: Nootropics Thread Index

  • Location:Netherlands

Posted 08 October 2011 - 09:58 AM

MODS: can we get a new MB section, like resveratrol and move the existing MB posts into it? That way we can also create some sticky posts with dosage, etc?


Hmm, interesting idea, but I doubt it would fly. The higher-ups are fairly cautious about creating new subforums. Despite its promise, I don't think there's enough threads (or research) yet to warrant a dedicated forum.

But the several mega threads do make it difficult to find answers without investing a lot of time (and frankly there's a lot of unnecessary info to wade through, like the way this thread keeps coming back to MAOIs). It would be nice to provide easier access, somehow. Perhaps a thread or longer entry in a thread index with links to the best posts/discussions on research and aspects of usage?

Maybe we can make and maintain an index thread with links to all the important posts that are all over the place as a compromise? We all (or to use the word community for a change) are able to contribute to this thread to make it work. In case this succeeds, this thread can be made sticky. The down voting button can be used to signalize dubious content in this thread, after which this content can be removed by a mod.

Edited by Brainbox, 08 October 2011 - 10:01 AM.

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#10 MrHappy Re: Nootropics Thread Index

  • Location:Australia

Posted 08 October 2011 - 10:49 AM

In the absence of a new section, that would certainly be the next best thing. However, surely the mods would be open to tidying things up a bit? It'd save a lot of repeat questions. I think the length of these MB threads shows that a new section would benefit everyone.
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#11 chrono Re: Nootropics Thread Index

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Posted 08 October 2011 - 01:07 PM

@brainbox: that's precisely what I did with the pinned thread index in the nootropics forum. I left a call for contributions up for months, and with thousands of views I got suggestions for exactly 3 threads (and at a time when posting activity was much higher). The other dozens had to come from me doing searches and reading backwards through the entire topic list (have read about 2/3 of the topics in this subforum, though many are still in my notes and not in the index yet). In other words, I'd be surprised if the community would be that apt to undertake such an organizational project.

However, the index was very successful in cutting down on the incessant "do I need choline with my piracetam?" threads (there used to be at least one a day, it seemed), and other repeat questions. The same principle would probably help here, for those who don't want to read 500-post threads.

But the main problem will still be the linearity and multiple topics. I think what needs to be done first is to split the longer threads into smaller discussions; for instance, threads covering MAOI, dosage and research might make everything easier. Then perhaps links in the first post to the best points in the thread, or posts where some kind of breakthrough was made in the discussion. I'll have to read through the other long threads this weekend to get a better idea of the topic distribution.

As I said before, there really isn't enough MB research going on to warrant an entire section. If anything, it would probably encourage even more questions from people looking for easy answers without doing any research, which is too far in the opposite direction. I too think an organized index, and better thread cohesion, is the best solution to try first.

Edited by chrono, 08 October 2011 - 01:09 PM.

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#12 Brainbox Re: Nootropics Thread Index

  • Location:Netherlands

Posted 08 October 2011 - 02:23 PM

I agree about the amount of research, but it seems to be a very interesting compound regarding dose dependent effects. Apart from possible direct usefulness I think it is interesting also in a kind of historical perpective. It's one of the first medications discovered, ditched at one moment in time, reappearing decades later with added insight regarding dose dependent multiple benefits. Kind of highlighting the limiting tunnel vision we all have and that looking out of the box can always be good.

I didn't notice the noot index, probably because i do not frequent that part of the forum that much, but yes, that's kind of what i was thinking of. It also illustrates that moderators can only help out a bit to keep the forum clean, but if initiatives do not touch down properly and are not endorsed by the community, they will fail irrespective of the good intentions or cleverness.

Cleaning up threads does cost a lot of time and especially in active threads could be prone to conflictious situations since one persons garbage can be another persons lifework achievement.
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#13 chrono Re: Nootropics Thread Index

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Posted 08 October 2011 - 03:01 PM

I agree completely with your opinion about how interesting it is. All I was saying was that there are only 29 threads about this substance here (compared to hundreds for some others), and there is only a handful of things to say about it given the amount of current research available. But my research on it has not been thorough, so if it really is likely to warrant as much discussion as resveratrol, someone do correct me.

It also illustrates that moderators can only help out a bit to keep the forum clean, but if initiatives do not touch down properly and are not endorsed by the community, they will fail irrespective of the good intentions or cleverness.

I'm really not sure what you mean by this, since the thread index here in no way illustrates a failure of its stated goals. In fact, I'd call it a huge success in helping to clean up the endless repetition in this forum. This is because I did more than "help out a bit," by spending dozens (if not hundreds) of hours scouring the threads in this forum, so other people could find the information more easily.

I agree that the "community initiative" failed, but all this illustrates is that no one besides me is willing to perform what is an onerous and research-intensive task which was 100% my own idea. And while it does only represent my opinion of what is valuable (aside from the 3 mega-popular threads that were suggested), there have been 0 criticisms in the past year despite the 32,000 views.

Cleaning up threads does cost a lot of time and especially in active threads could be prone to conflictious situations since one persons garbage can be another persons lifework achievement.

I was only talking about splitting mega-threads into more well-defined topics. This does not imply deletion of anything.

And in general, the only thing I delete in these kinds of threads are one-sentence questions that were already answered earlier in the thread (e.g. "where can I buy this stuff" or "doesn't it turn your pee blue").

Edited by chrono, 08 October 2011 - 03:27 PM.

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#14 Brainbox Re: Nootropics Thread Index

  • Location:Netherlands

Posted 08 October 2011 - 03:34 PM

Ok, I was interpreting the contribution / view ratio as somewhat negative as a community effort, but you're right, it's a huge benefit looking at it that way.

During the evenings next week I would be able to do something like this to help out or continue your effort. I will start an MB index thread, skim the MB threads, clean the repetitive subjects and create links to interesting stuff in the index. If you or someone else would like to join we should think of a mechanism to distribute threads over participants.

Good idea? If yes, who would like to join and help?
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#15 MrHappy Re: Nootropics Thread Index

  • Location:Australia

Posted 08 October 2011 - 10:15 PM

I can help. How about this?

Topics:

Research-
History of non-nootropic uses
Links to published journals
Leucomethylene blue, azure B
Dose dependant effects
Member contributions / feedback

FAQ-
Where to buy
dosage calculation and dispensing
Known Risks / interactions / MSDS
Will my pee or sclera turn blue?




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#16 semi-retarded-individual Re: Nootropics Thread Index

  • Location:Washington DC

Posted 08 October 2011 - 11:14 PM

I don't mean to volunteer anyone else but Devin seems to have a good handle on MB and was a major contributor to this thread. ;)
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#17 rwac Re: Nootropics Thread Index

  • Location:Dimension X
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Posted 10 October 2011 - 04:04 PM

[Yesterday I split off a MAOI thread. Today I'll work on one for dosing, maybe nootropic and non-nootropic research, and some of the more specific categories Mr Happy mentioned (if there's enough for full threads)]


I really appreciate this, it will make it a lot easier to give someone a link for MB info.
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#18 chrono Re: Nootropics Thread Index

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Posted 11 October 2011 - 12:18 AM

I just finished re-rendering the big MB threads; I'm bumping them all so everyone will know where they are.

Methylene Blue Experiences
Methylene Blue Dosing and Products
Methylene Blue Research
Methylene Blue and MAO Inhibition

These topics are interrelated, but we should try our best to keep discussions as topically segregated as realistically possible, to make the information easier to find in the future.

[also moved all the discussion about splitting those threads into this index]

Edited by chrono, 25 October 2011 - 09:16 AM.

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