niner, on 08 May 2013 - 02:49 AM, said:
zorba990, on 07 May 2013 - 03:24 PM, said:
GetMaxed, on 26 August 2012 - 03:16 PM, said:
Liposomal glutathione helps it survive the digestive tract, but it has the same problem as intravenous GSH in that in can't enter most cells in your body to raise intra-cellular levels.
Liposomal seems to work http://www.ncbi.nlm....ubmed/20535554/
Any studies to support that acetyl form works better?
That paper is in vitro- is there anything looking at efficacy in humans? Or animals? GetMaxed says it survives the GI tract, but didn't provide any evidence. The in vitro work suggests that it does penetrate the cell wall, but we don't know if it would hang around long enough, in high enough concentration, to do the same thing in humans.
I haven't seen any human studies on lipsomal GSH, I remember there being a rabbit in vivo study.
> GetMaxed says it survives the GI tract, but didn't provide any evidence
Thats just a general properties of liposomal delivery systems, nothing specific to glutathione.
I had the impression that the in-vitro works says it doesn't penetrate the cell wall, but has be broken down to the aminos, then transported into the cell and synthesized.
"Blocking γ-glutamylcysteine synthetase with buthionine sulfoxamine prevented replenishment with liposomal-GSH demonstrating the requirement for catabolism and resynthesis."
But it's odd then that there was such a difference with normal glutathione, as the same should be able to happen with that, so not sure what's happening there.
Also in that link article said
"In mixed neuronal/glial cultures depleted of intracellular GSH"
from what I've been researching restoring levels when they are already low, below that of homeostatic levels, isn't as relevant, even NAC will do the job then.
For what we're interested in, getting that extra extension in health/lifespan, there's a other factors that are at play too. Lately I've been looking into the epigenetic changes which downregulate the exp
ression of Nrf2 and all the glutathione enzymes. I should finish up my article I've been writing on it...
But getting back on topic it would be good to see some more studies with SAG, especially comparing with liposomal, RibCys and NAC.