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Am I doing something wrong?


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#1 glasstiger50

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Posted 03 November 2010 - 06:51 AM


So I have recently been introduced to nootropics, mainly racetams. About 5-6 weeks ago, I started taking Aniracetam with Alpha GPC. I would take 2-3 750mg pills of aniracetam a day, with 2 300mg pills of Alpha GPC to accompany it. I wasn't feeling or noticing ANYTHING different about my cognition, memory, or just overall awareness. I kept this regiment going for about 3 weeks, and nothing changed. Instead, since I had read since Aniracetam is fat-soluble and people who do not respond to fat-soluble nootropics usually respond to water-soluble nootropics, I began taking Oxiracetam. Based on what I had researched, it seemed Oxiracetam had a much better effect on its users. So again, I took 2-3 750 mg of Oxiracetam a day with 2 300mg pills of Alpha GPC. Similarly, I felt nothing. I decided maybe it was the choline source I was taking that wasn't doing the trick. As of right now, I am taking 2 750 mg pills of Oxiracetam a day, with 1-2 500mg pills of Centrophenoxine. I have been doing this for about a week and a half and I have yet to see ANY results. Now, I'm not expecting to become a super-genius or anything, but I do not notice ANY significant difference in ANY aspect of my cognition, memory, alertness, ability to focus, etc. Is there something I am missing / doing wrong?

#2 kassem23

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Posted 03 November 2010 - 10:28 AM

No, nothing you are doing wrong. It just seems the placebo effect just didn't follow you this time. It's not well established that healthy individuals experience anything what-so-ever from Piracetam treatment. Stop wasting your money and try something else.

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#3 smoothVTer

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Posted 03 November 2010 - 06:16 PM

After 5 or 6 years of chronic stress and depression, I couldn't sleep, think, or create anymore yet alone concentrate or be productive at work. My job requires a lot of "brain RAM", in that I must hold and then process many stashes of information at any one time and somehow glue them together, then modify to create the final product. (programming / computer science type stuff) Prior to finding imminst.org I was struggling bad, about to lose my job yet could not find energy or motivation to change anything - and could not make sense out of what used to be simple tasks. Add the sleep problems into the mix and you have a seriously cognitively inhibited individual, myself.

I would say I suffered heavy damage from my problems and my own mind's thoughts were acting against me in every space.

So for someone like me - who was NOT healthy to begin with, who really felt sick and could not even hold a friendly conversation with pals - nootropics worked for me and continue to produce the effects I want. I wish there was someway to compare effects - like go back in time to when my brain was functioning normally and test out various nootropics, then compare results from the past few months. Alas, I must stick with what seems to be working and continue the trend of positivity and productivity I have been blessed with through ongoing research the past 5 years.

#4 glasstiger50

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Posted 04 November 2010 - 08:19 PM

Would I maybe respond to another nootropic? Piracetam? Modafinil? Anything else that is worth trying?

If I didn't respond to Aniracetam or Oxiracetam, would I respond to Piracetam?

Edited by glasstiger50, 04 November 2010 - 08:29 PM.


#5 adamh

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Posted 04 November 2010 - 10:49 PM

Would I maybe respond to another nootropic? Piracetam? Modafinil? Anything else that is worth trying?

If I didn't respond to Aniracetam or Oxiracetam, would I respond to Piracetam?


It's possible but you may simply be a non responder. Older folk are more likely to notice a benefit than younger ones. I use piracetam and it works for me.

#6 glasstiger50

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Posted 05 November 2010 - 04:06 AM

I just ordered some Piracetam. A lot of people says it works for them, so I'm keeping my fingers crossed. Also, I looked at some modafinil. Holy crap that stuff is expensive!! Is it that expensive everywhere?

#7 Saha

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Posted 06 November 2010 - 08:34 PM

After 5 or 6 years of chronic stress and depression, I couldn't sleep, think, or create anymore yet alone concentrate or be productive at work. My job requires a lot of "brain RAM", in that I must hold and then process many stashes of information at any one time and somehow glue them together, then modify to create the final product. (programming / computer science type stuff) Prior to finding imminst.org I was struggling bad, about to lose my job yet could not find energy or motivation to change anything - and could not make sense out of what used to be simple tasks. Add the sleep problems into the mix and you have a seriously cognitively inhibited individual, myself.

I would say I suffered heavy damage from my problems and my own mind's thoughts were acting against me in every space.

So for someone like me - who was NOT healthy to begin with, who really felt sick and could not even hold a friendly conversation with pals - nootropics worked for me and continue to produce the effects I want. I wish there was someway to compare effects - like go back in time to when my brain was functioning normally and test out various nootropics, then compare results from the past few months. Alas, I must stick with what seems to be working and continue the trend of positivity and productivity I have been blessed with through ongoing research the past 5 years.

Are you sure that nootropics is the correct medication? The state of mind you describe looks somewhat similar to clinical depression. And depression can dramatically affect productivity, concentration and memory. Have you visited a doctor?

#8 smoothVTer

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Posted 08 November 2010 - 05:01 PM

After 5 or 6 years of chronic stress and depression, I couldn't sleep, think, or create anymore yet alone concentrate or be productive at work. My job requires a lot of "brain RAM", in that I must hold and then process many stashes of information at any one time and somehow glue them together, then modify to create the final product. (programming / computer science type stuff) Prior to finding imminst.org I was struggling bad, about to lose my job yet could not find energy or motivation to change anything - and could not make sense out of what used to be simple tasks. Add the sleep problems into the mix and you have a seriously cognitively inhibited individual, myself.

I would say I suffered heavy damage from my problems and my own mind's thoughts were acting against me in every space.

So for someone like me - who was NOT healthy to begin with, who really felt sick and could not even hold a friendly conversation with pals - nootropics worked for me and continue to produce the effects I want. I wish there was someway to compare effects - like go back in time to when my brain was functioning normally and test out various nootropics, then compare results from the past few months. Alas, I must stick with what seems to be working and continue the trend of positivity and productivity I have been blessed with through ongoing research the past 5 years.

Are you sure that nootropics is the correct medication? The state of mind you describe looks somewhat similar to clinical depression. And depression can dramatically affect productivity, concentration and memory. Have you visited a doctor?



I've visited a dozen allopathic doctors, ending with specialists - allergist, endocrinologist, rheumatologist, neurologist. Also went to two naturopaths, threes DO's, 2 phychologists. No one could tell me why I was tired all the time despite sleeping solid 7 hours a night, why I couldn't think clearly or why my verbal skills were waning at the age of 28. It was difficult to keep eye contact with people while speaking to them, which made it difficult to build and support relationships. Backstory to this is: 5 years ago went through 1st major depressive episode, brought on by (surprise!) the end of a long relationship. Got into bad cognitive habits: generalizing, catastrophic thinking, snowball-effect analyzation, self-seclusion, social anxiety. Eventually became suicidal. On advice of clinician, took an SNRI for 1 year (venlafaxine) which got me out of the ditch I was laying in, able to function semi-normally again. Tapering off the venlafaxine was pretty entertaining ... the feeling of flying while walking and head-in-clouds sensations. After cessation, had a bit of a hard time but started exercising again and it helped prevent these relapses, plus getting muscles is an ego boost in itself. Also went to cognitive behavioral therapy with another psych, took care of my issues, and they don't bother me anymore. I am not and have not been depressed in the slightest for almost 3 years now.

However despite the lack of depression, I could not return to my pre-depression energy levels nor could I think clearly as before.

In essence, I feel the medical establishment failed me. The only thing they were good for was to point me away from things that were NOT the problem. I've got a binder full of medical tests 100 pages thick. All inconclusive or negative for the most part, besides the "incidentalomas".

My theory is this: I lived with untreated depression for more than a year: the nightmares and middle-of-night awakenings, the very real and present stress and pressure I put myself under day and night, and the poisonous thoughts I held about the world and myself in it generated such a strong long-term stress response that I physically damaged my mind. My exploration with nootropics here is more of an attempt to re-build my mind to a state that I remember it to be in 5-6 years ago, when I was clear, strong in body and mind, able to stand up for myself, and a social butterfly.

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#9 jadamgo

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Posted 08 November 2010 - 05:48 PM

Hmmm... consider this a crackpot theory, but you could try taking modafinil in the mornings and then some centrally active (read: sleepiness-causing) antihistamine at night. Apparently, modafinil's mechanism of action involves increased central histamine activity, but central histamine activity re-regulates pretty quickly. That's why benadryl or other antihistamines are only useful sleep aids for a few nights in a row, but then they stop working. But if you took modafinil in the morning and benadryl at night, you might be able to keep the central histamine system from downregulating and reducing the effectiveness of the modafinil.

Anyone with more thorough understanding/experience of modafinil's pharmacology is welcome to comment on that. I've never tried modafinil, and this is just a random thought that may or may not work.




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