I can't seem to find much information on the ability to take St. John's Wort and SAMe together. I've seen it suggested that combining the two could cause serotonin syndrome, but not much real info. I've seen a few mention on forums/reviews of taking the combination, but I don't know of the dosing. Plus, I see contradicting info on the actual effects of SJW and SAMe, such as SJW not being an SSRI like it has been believed to be. I haven't seen any studies of the sort, but read an article that said two doctors that are experienced with SJW claim that SJW does not put one at risk of serotonin syndrome (I can't recall now if that had anything to do with SAMe combo, or just that SJW hasn't caused serotonin syndrome).
So does anyone have info on the subject? Experience with combining the two? What dosing?
I take 2-3 Amoryn (SJW standardized) a day. I probably don't need that much, but at times I have and just kept it at that amount. It has worked, but I'd like to achieve a brighter outlook which I think could also help with motivation. I'm not depressed, but feel motivated when I'm in a particularly good mood. So thought SAMe might be worth a try (think I'll do a little experimenting with L-Tyrosine earlier too). Plus, SAMe is good for the liver and since I have high histamine I'm likely an undermethylator.
I'm not saying I wouldn't reduce my SJW dosing, but wonder to what extent I must do it. Meaning if there's a great risk I'd reduce it for some time before trying SAMe. Either way, I'd start at the smallest SAMe dose I could find (likely 100mg).