10 replies to this topic

[Cephalon]

Hi dear Imminst Community!

While reading a bit on EFA I came across NAPEs:

Wikipedia Article on NAPEs

NAPEs are hormones that are released in the bloodstream when dietary fat is beeing processed.
NAPEs mediate appetite supression in the hypothalamus.

Here an Reuters article from 2008 on potential benefits of NAPEs in obesity: Reuters

Beside that NAPEs are endocannabinoid precursors (Anandamide).

NAPEs can be found in many vegetable oils, like olive il, hemp oil, avocado oils etc.

(I found a few online vendors that carry NAPE isolates for recreational use)

Do you see any benefits in adding small additional amounts of NAPEs to one's diet ?

Probably as a non stimulant weight loss aid, in treatment of chronic pain, or for potential (?) antidepressant properties?


I will try to obtain a few studies on this subject later this day.

Thank you very much for your input on this (how I find) interesting subject!


Best regards , Cephalon



EDIT:
While NAPEs seem to suppress apetite, Anandamide an endocannabinoid metabolite of NAPEs appears to induce overeating in mice:
Claire M. Williams and T. C. Kirkham "Anandamide induces overeating: mediation by central cannabinoid (CB1) receptors" Psychopharmacology Volume 143, Number 3, 315-317 01/13/1999

Further hypothetical applications for NAPEs and Anandamide:
Sleep induction
Mechoulam, R | Fride, E | Hanus, L | Sheskin, T | Bisogno, T | Di Marzo, V | Bayewitch, M | Vogel, Z "Anandamide may mediate sleep induction" Nature. Vol. 389, no. 6646, pp. 25-26. Sep 1997

Breast Cancer
Luciano De Petrocellis * , †, Dominique Melck * , ‡, Antonella Palmisano §, Tiziana Bisogno ‡, Chiara Laezza ¶, Maurizio Bifulco ¶, and Vincenzo Di Marzo ‡ , "The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation" PNAS July 7, 1998 vol. 95 no. 14 8375-8380

Edited by Cephalon, 13 February 2011 - 04:15 PM.

[Cephalon]

Protection of brain cells as respond to neurotoxins
Harald S. HansenA, *, Lotte LauritzenA, Birthe MoesgaardA, Anne Mette StrandA and Henrik H. HansenA "Formation of N-Acyl-phosphatidylethanolamines and N-Acylethanolamines: Proposed Role in Neurotoxicity" Biochemical Pharmacology Volume 55, Issue 6, 15 March 1998, Pages 719-725

Raphael Mechoulam, a, David Panikashvilib and Esther Shohamic "Cannabinoids and brain injury: therapeutic implications" Trends in Molecular Medicine Volume 8, Issue 2, 1 February 2002, Pages 58-61

Speculations on neuroprotective properties of NAPEs in aging brains
Birthe Moesgaard*, Gitte Petersen*, Jerzy W. Jaroszewski† and Harald S. Hansen1,* "Age dependent accumulation of N-acyl-ethanolamine phospholipids in ischemic rat brain: a 31P NMR and enzyme activity study" June 2000 The Journal of Lipid Research, 41, 985-990

Edited by Cephalon, 13 February 2011 - 05:02 PM.

[Cephalon]

I received my order on NAPEs in the mail today.
The material has an amber color and is of an smooth, fibrous, sticky texture.
It has a sharp chemical smell on it, which might come from the solvent (prob. acetone).
The taste is fatty, like a mild vegetable oil e.g. flax oil.
The NAPE I ordered is derived from olive oil.

First test:
50mg ingested: no noticable effects, neither on mood nor on appetite.

Second test:
+120min - 100mg ingested: noticable effect: relaxion, calmnes, slower reaction, mild euphoria
no noticable appetite suppression (prob. even more appetite)
(this dose is probably not usefull for daily supplementation, at least not daytime)

(tests were done on empty stomach after an approx. 8 h fasting period)

Edited by Cephalon, 21 February 2011 - 11:42 AM.

[Cephalon]

90min past second test: 1. intense reduction in appetite
(60 min past ingestion I got really hungry, so I cooked something, when I was finished cooking about 90min after ingestion I hardly managed to eat on spoon)
though this effect seems paradox to me, since NAPE is supposed to decrease appetite and its metabolites (Anadamine ..) are supposed to increase appetite ...
2. slight alteration in state of mind, definately mild cannabinoide activity (i have no tolerance to cannabinoids/do not use drugs recreational)
which again makes it unsuitable for daytime use
3. there might be a reduction in pain sensitivity, lighly burned myself while cooking, without much sensation of pain

[Cephalon]

Sumary of test 2: appetite reduction lasted the whole day, I have lived from a dozen cashews in the pm and 6 almonds in pm without feeling hungry, thinking of food ... but it feels different than appetite supression drugs from the amphetamine class, the appetite supression feels completly natural, as if your last meal was just one hour ago and you feel just fine, not over-eaten or with the amphetamin common disgust towards food, just not hungry.


(If a kind moderator sees this, could s(he) make all my posts to one?, that would be great.)

[Cephalon]

I'm glad to see there are finally weightloss products popping up on the market using N-oleyl-phosphatidylethanolamine (NOPE) as an active ingredient. Still curious if NAPEs will be explored for this purpose any further. I will have to look deeper in the mechanism of action of NOPEs, but given the similar structure it might work via the endocannabinoid system as well. 

 

http://www.cheminutra.com/phospholean/

 

 

Edited by Cephalon, 20 April 2014 - 10:29 PM.

[Cephalon]

If anyone could come up with an easy synthesis starting from plant oils?

 

 

This is something I found online:

 

Safflower Oil - very strong pain killer
Peanut Oil - Pain killing, cb2 activty
Hempseed oil - unknown, presumably cb1/cb2 agonist imo, I'd lean toward cb1. from my tests with it, its definitely less cb2 than peanut oil, but less cb1 than rice bran. 
Rice Bran Oil - Cb1 activity, Euphoria.
Olive Oil - cb2 activty, pain killing

 

There seem to be just two online suppliers of NAPES, both are US based. 

 

Thanks!

 

[GoingPrimal]

Very interesting finds.

[blood]

Ergo log article on PhosphoLean - worth a read:
http://www.ergo-log....iet-easier.html

A retail product containing PhosphoLean:
http://www.advocare....trim/T5000.aspx

Edited by blood, 21 April 2014 - 03:01 PM.

[tintinet]

I received my order on NAPEs in the mail today.
The material has an amber color and is of an smooth, fibrous, sticky texture.
It has a sharp chemical smell on it, which might come from the solvent (prob. acetone).
The taste is fatty, like a mild vegetable oil e.g. flax oil.
The NAPE I ordered is derived from olive oil.

First test:
50mg ingested: no noticable effects, neither on mood nor on appetite.

Second test:
+120min - 100mg ingested: noticable effect: relaxion, calmnes, slower reaction, mild euphoria
no noticable appetite suppression (prob. even more appetite)
(this dose is probably not usefull for daily supplementation, at least not daytime)

(tests were done on empty stomach after an approx. 8 h fasting period)

Where did you get your NAPEs?

[adamh]

I would be interested too.