This study found that patients who lose weight rapidly after gastric bypass and develop massive skin laxity have a shortage of heparan sulfate. The other components in skin such as collagen, elastin and GAG were either normal or increased.
The number of post-bariatric patients had a significant increase over the last years, and a better understanding of the consequences of massive weight loss on skin is imperative. Despite weight-loss-related changes in collagen and elastin have been reported, less is known about changes in another of the matrix components of the skin, the glycosaminoglycans. The objective of this study is to evaluate abdominal skin glycosaminoglycans concentrations and perlecan and collagen III expression in post-bariatric female patients.
The major glycosaminoglycans found were dermatan sultafe and hyaluronic acid; the others were found in smaller amounts. The skin of the post-bariatric patients had lower concentrations of heparan sulfate (p = 0.002) while hyaluronic acid, dermatan sulfate, and chondroitin sulfate concentrations were similar to the lean women's skin. Post-bariatric skin showed decreased expression of perlecan and increased expression of collagen III. No correlation was found among glycosaminoglycans concentrations and age, body mass index, frequency of pregnancies, or skin types, but it was observed in higher skin heparan sulfate concentrations in post-bariatric patients who had their weights stabilized for over than 24 months (p = 0.000).
Abdominal skin of post-bariatric women presented decreased heparan sulfate concentrations and perlecan expression and increased expression of collagen III.
This makes sense as the skin needs more tensile strength when stretched. HS is also decreased in aged human skin. PMID:21426414. I was searching for ways to increase HS short of supplementing with GAG supplements and found this study on the effects of manganese. I wrote an earlier post on the effect of vitamin K on GAG production. In fact, induced manganese deficiency was shown to decrease levels of HS. PMID:9845481
Can this possibly prevent saggy skin formation during controlled fat loss or possibly reverse it after it has set in? Some forums suggest that saggy skin post weight loss will normally take care of itself after many years. Can manganese and HS levels be a determining factor in the rate of regression ?
Edited by Lufega, 11 October 2011 - 09:41 PM.