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Dietary supplement augments spatial learning, brain mass, mitochondrial electron transport chain activity in old mice

aging mitochondria

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#1 noos

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Posted 04 December 2011 - 02:31 PM


A complex dietary supplement augments spatial learning, brain mass, and mitochondrial electron transport chain activity in aging mice.
Aksenov V, Long J, Liu J, Szechtman H, Khanna P, Matravadia S, Rollo CD.
Source

Department of Biology, McMaster University, 1280 Main St W., Hamilton, ON, Canada, L8S 4K1.
Abstract

We developed a complex dietary supplement designed to offset five key mechanisms of aging and tested its effectiveness in ameliorating age-related cognitive decline using a visually cued Morris water maze test. All younger mice (<1 year old) learned the task well. However, older untreated mice (>1 year) were unable to learn the maze even after 5 days, indicative of strong cognitive decline at older ages. In contrast, no cognitive decline was evident in older supplemented mice, even when ∼2 years old. Supplemented older mice were nearly 50% better at locating the platform than age-matched controls. Brain weights of supplemented mice were significantly greater than controls, even at younger ages. Reversal of cognitive decline in activity of complexes III and IV by supplementation was significantly associated with cognitive improvement, implicating energy supply as one possible mechanism. These results represent proof of principle that complex dietary supplements can provide powerful benefits for cognitive function and brain aging.
PMID: 22120182 [PubMed - as supplied by publisher]
http://www.ncbi.nlm....pt=AbstractPlus


Someone posted the ingredients in a group:


Ingredients included in the complex dietary supplement

Ingredient

Mouse dose (mg/day/100 mice)

Vitamin B1

30.5

Vitamin B3 (niacin)

30.5

Vitamin B6

60.0

Vitamin B12

0.18

Vitamin C

350.6

Vitamin D

0.02

Acetyl-l-carnitine

146.5

Alpha-lipoic acid

182.9

Acetylsalicylic acid

132.1

Beta-carotene

21.9

Bioflavonoids

792.7

Chromium picolinate

0.30

Folic acid

0.61

Garlic

3.81

Ginger root extract

600.4

Gingko biloba

18.3

Ginseng

631.1

Green tea extract

487.8

l-Glutathione

30.5

Magnesium

45.7

Manganese

19.1

Melatonin

0.73

N-Acetyl cysteine

304.9

Potassium

18.1

Rutin

304.9

Selenium

0.05

Vitamin E

326.8

Cod liver oil (omega 3)

1,219.5

Coenzyme Q10

60.0

Flax seed oil

1,219.5

#2 Joiedevivre62

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Posted 01 March 2013 - 02:18 PM

I supplement my husband (73) with nearly all of that and it helps.

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#3 Michael Price

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Posted 29 September 2014 - 08:21 PM

The same formulation also reduced cancer and increased longevity in mice. An anti-aging smart pill.




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