A complex dietary supplement augments spatial learning, brain mass, and mitochondrial electron transport chain activity in aging mice.
Aksenov V, Long J, Liu J, Szechtman H, Khanna P, Matravadia S, Rollo CD.
Source
Department of Biology, McMaster University, 1280 Main St W., Hamilton, ON, Canada, L8S 4K1.
Abstract
We developed a complex dietary supplement designed to offset five key mechanisms of aging and tested its effectiveness in ameliorating age-related cognitive decline using a visually cued Morris water maze test. All younger mice (<1 year old) learned the task well. However, older untreated mice (>1 year) were unable to learn the maze even after 5 days, indicative of strong cognitive decline at older ages. In contrast, no cognitive decline was evident in older supplemented mice, even when ∼2 years old. Supplemented older mice were nearly 50% better at locating the platform than age-matched controls. Brain weights of supplemented mice were significantly greater than controls, even at younger ages. Reversal of cognitive decline in activity of complexes III and IV by supplementation was significantly associated with cognitive improvement, implicating energy supply as one possible mechanism. These results represent proof of principle that complex dietary supplements can provide powerful benefits for cognitive function and brain aging.
PMID: 22120182 [PubMed - as supplied by publisher]
http://www.ncbi.nlm....pt=AbstractPlus
Someone posted the ingredients in a group:
Ingredients included in the complex dietary supplement
Ingredient
Mouse dose (mg/day/100 mice)
Vitamin B1
30.5
Vitamin B3 (niacin)
30.5
Vitamin B6
60.0
Vitamin B12
0.18
Vitamin C
350.6
Vitamin D
0.02
Acetyl-l-carnitine
146.5
Alpha-lipoic acid
182.9
Acetylsalicylic acid
132.1
Beta-carotene
21.9
Bioflavonoids
792.7
Chromium picolinate
0.30
Folic acid
0.61
Garlic
3.81
Ginger root extract
600.4
Gingko biloba
18.3
Ginseng
631.1
Green tea extract
487.8
l-Glutathione
30.5
Magnesium
45.7
Manganese
19.1
Melatonin
0.73
N-Acetyl cysteine
304.9
Potassium
18.1
Rutin
304.9
Selenium
0.05
Vitamin E
326.8
Cod liver oil (omega 3)
1,219.5
Coenzyme Q10
60.0
Flax seed oil
1,219.5