Let's discuss... is olive leaf extract a potential nootropic?
Abstracts, experiences, and comments.
Posted 08 December 2011 - 12:01 AM
Posted 08 December 2011 - 01:29 AM
Posted 08 December 2011 - 02:12 AM
Let's discuss... is olive leaf extract a potential nootropic?
Abstracts, experiences, and comments.
Edited by JChief, 08 December 2011 - 02:13 AM.
Posted 08 December 2011 - 01:13 PM
Posted 09 December 2011 - 11:34 AM
Edited by JChief, 09 December 2011 - 11:35 AM.
Posted 09 December 2011 - 12:25 PM
Posted 09 December 2011 - 12:45 PM
Posted 09 December 2011 - 03:04 PM
it may be neuroprotective and preventive against alzheimers and similar diseases, but for now this is just a hypothesis based on rat/mice studies.
it may also have anti-aging properties.
www.scipharm.at/download.asp?id=629
i wonder, whether it is found only in leaf or is it also present in olive oil?
Posted 09 December 2011 - 03:08 PM
No side effects to speak of here. I haven't been "sick" in years.
Posted 09 December 2011 - 04:07 PM
No side effects to speak of here. I haven't been "sick" in years.
Awesome. Time to see if a megadose works... well, tomorrow maybe. If not, next week.
Edited by JChief, 09 December 2011 - 04:08 PM.
Posted 12 December 2011 - 10:42 PM
Posted 12 December 2011 - 11:22 PM
Posted 12 December 2011 - 11:24 PM
Posted 13 December 2011 - 06:07 PM
Can't edit on my phone :-( but the thyroid hormones would also explain the warm face.
In a study published in "Phytotherapy Research" in 2002, researchers from King Saud University in Saudi Arabia investigated the effects of olive leaf on the thyroid. Rats were fed extracts of olive leaf for 14 days, at which time researchers ran blood tests to check for thyroid hormone levels. Olive leaf had a significant effect on the thyroid, stimulating a strong increase in triiodothyronin, and a smaller increase on thyroxin -- two important thyroid hormones responsible for regulating metabolism. In addition, olive leaf decreased levels of thyroid-stimulating hormone -- a chemical secreted by the pituitary to stimulate thyroid activity. These results show olive leaf has a direction action on the thyroid gland, and may help to balance thyroid hormones in people suffering from thyroid diseases.
Posted 13 December 2011 - 07:37 PM
Posted 13 December 2011 - 08:24 PM
Any ideas on why some people feel ill when taking Olive leaf ? Is it really because of some kind of Herx. reaction ?
Edited by devinthayer, 13 December 2011 - 09:00 PM.
Posted 13 December 2011 - 09:12 PM
Posted 13 December 2011 - 09:49 PM
Functional interference between glycogen synthase kinase-3 beta and the transcription factor Nrf2 in protection against kainate-induced hippocampal cell death.
Rojo AI, Rada P, Egea J, Rosa AO, López MG, Cuadrado A.
Source
Instituto de Investigaciones Biomédicas "Alberto Sols" UAM-CSIC, Departamento de Bioquímica, and Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas (CIBERNED), Facultad de Medicina, Universidad Autónoma de Madrid, Madrid, Spain.
Abstract
Excitotoxicity mediated by glutamate receptors may underlay the pathology of several neurologic diseases. Considering that oxidative stress is central to excitotoxic damage, in this study we sought to analyze if the transcription factor Nrf2, guardian of redox homeostasis, might be targeted to prevent kainate-induced neuron death. Hippocampal slices from Nrf2 knockout mice exhibited increased oxidative stress and cell death compared to those of control mice in response to kainate, as determined with the redox sensitive probes 2,7-dichlorodihydrofluorescein diacetate (H(2)DCFAC) and propidium iodide and lactate dehydrogenase release, respectively, therefore demonstrating a role of Nrf2 in antioxidant protection against excitotoxicity. In the hippocampus of mice intraperitoneally injected with kainate we observed a rapid activation of Akt, inhibition of GSK-3beta and translocation of Nrf2 to the nucleus, but after 4 h Akt was inactive, GSK-3beta was active and Nrf2 was mostly cytosolic, therefore extending our previous studies which indicate that GSK-3beta excludes Nrf2 from the nucleus. Lithium, a GSK-3beta inhibitor, promoted Nrf2 transcriptional activity towards an Antioxidant-Response-Element (ARE) luciferase reporter and cooperated with sulforaphane (SFN) to induce this reporter and to increase the protein levels of heme oxygenase-1 (HO-1), coded by a representative ARE-containing gene. Conversely, ARE activation by SFN was attenuated by over-expression of active GSK-3beta. Finally, combined treatment with SFN and lithium attenuated oxidative stress and cell death in kainate-treated hippocampal slices of wild type mice but not Nrf2 null littermates. Our findings identify the axis GSK-3beta/Nrf2 as a pharmacological target in prevention of excitotoxic neuronal death. PMID:18619545 [PubMed - indexed for MEDLINE]
Posted 13 December 2011 - 10:31 PM
That sounds like Hemianopsia. Strange! You think this was from the olive leaf or the magnesium oxide ? Mag. oxide is crap, I don't see how it can be blamed.
http://en.wikipedia....iki/Hemianopsia
Posted 14 December 2011 - 12:44 AM
Posted 22 December 2012 - 04:19 PM
Posted 22 December 2012 - 04:27 PM
Posted 09 March 2013 - 06:15 PM
Posted 09 August 2013 - 07:05 AM
I take 1g/day. It causes sinus bradycardia. Which my doc says is normal. It lowers bp 11 points. You can feel it relax your arteries.Huh...
Well I might try some and see if I notice anything. I'll start at 500mg 18% Oleuropins (which is converted into hydroxytyrosol in vivo). I'll work my way up until I get side effects. The stuff is cheap, might as well. I do notice a boost in cognition from extra virgin olive oil, similar to Fish Oil, but that could just be the oil, unrelated to the oleuropein.
Anyone notice any side effects from it?
Posted 24 August 2016 - 04:08 AM
Edited by sativa, 24 August 2016 - 04:12 AM.
Posted 11 November 2018 - 09:22 PM
I'll start at 500mg 18% Oleuropins (which is converted into hydroxytyrosol in vivo).
Does anyone know a source for @devinthayer's claim oleoropins would convert into hydrotyrosol in vivo?
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