Upon request from another longecity member, I am starting a thread on pharmacological agents that have been investigated for their use in treating or preventing myopia.
Currently, my ability to post links is limited since I am a new member. Once my member status is upgraded, I will post links to studies and resources.
Note: I do not advocate use of any of these drugs/supplements. The content of this post is for informational use only.
Potential Substances for Myopia Treatment:
-Atropine eye drops: non-selective muscarinic receptor antagonist. Relatively long duration of effect when used ophthalmically. Literature states a half-life of 2 hours (most likely when used systemically). However, when applied to the eye as eye drops, the effect may last 48 hours, sometimes more.
-Pirenzepine eye drops: Relatively selective M1 subtype muscarinic receptor antagonist. Low side-effect profile compared to atropine.
-Tropicamide eye drops: Short-acting cycloplegic agent. Relaxes ciliary muscle, blocks accommodation. Short half-life compared to atropine.
-Epinephrine (Adrenaline) eye drops
-Pilocarpine eye drops
-GABA-A-rho (formerly called GABA-C) receptor antagonists: show dose-dependent inhibition of myopia development.
-Zinc eye drops: May reduce development of myopia, possibly as a GABA-A-rho antagonist (personal inference).
-Labetalol eye drops: 0.25 diopter (D) improvement in 68% of eyes observed. (One study with no control for comparison).
-Timolol eye drops: may shift resting position of accomodation
Edited by Delafuente, 18 December 2011 - 08:26 PM.