It will probably downregulate some 5ht receptors after a period of use. This is an intermediary result of SSRIs as well so some effects may correlate between the two. Not saying it is safer than SSRIs, just throwing in my two cents.
The lack of grogginess is likely due to (pi)racetam's positive allosteric modulation of the NMDA receptors: more excitatory action.
I took alcar (1g-2g daily) and bacopa (.5g-2g daily) together for a month and did not notice any blaringly ill effects.
Fwiw bacopa (after a few weeks) made me less anxious about being lazy and slightly decreased some artifacts in my visual field. Even with the apparent boost in short term memory, albeit slight, these effects convinced me to persue other options.
What should be concluded then? Even though I don't experience any bad effects I still don't want to mess up my brain.
Also I will soon try piracetam, I guess it's the same as other racetams with bacopa, I still have 2 bottles of bacopa left and I quite seem to like it but it's impossible to use it alone, either I stay groggy and nosedive all the day either it makes me sleep for 10-12h albeit I don't have any of those effects if I take bacopa when tired, it rather removes tiredness, that's one weird nootropic.
Only racetam supplementation help countering those effects.