41 replies to this topic

[MarcD]

What supps could help with multiple sclerosis and why?

I'm thinking about curcumin, resveratrol, fish oil and a good multivitamin. Other ideas?

[malden]

Take a look on wiki about Idebenone )I take it for a muscle disorder and its working relativ good!

[MarcD]

I'll look it up. Specially the stuff about santhera pharma, cause they're from Switzerland like me.

any other stuff?

[Logan]

I'm assuming you have MS??? You're best bet is LDN-low dose naltrexone. A promising supplement would be luteolin.

Fish oil, Lion's Mane, and any of the oils with high amounts of GLA should be considered as well. Fish oil should be a given.

[Methos000]

Since MS is an autoimmune disorder, supps with immunomodulative properties are required. In addition to what's already been mentioned, aloe vera, Chang Shan (Dichroa febrifuga root), and Thymus Protein A (marketed as ProBoost) could be helpful.

You would also want to consider if you have been exposed to environmental toxins such as heavy metals (amalgam dental fillings, perhaps?) which are known to compromise the immune system. Andrew Cutler has wriiten a couple of excellent books on detoxification when such exposure has occurred.

Edited by Methos000, 21 March 2012 - 03:15 PM.

[TheSpawn]

What supps could help with multiple sclerosis and why?

I'm thinking about curcumin, resveratrol, fish oil and a good multivitamin. Other ideas?

see

http://www.direct-ms...upplements.html

and

http://www.terrywahls.com/... there are very interesting information for ms and curcumin ...

Edited by TheSpawn, 22 March 2012 - 10:23 AM.

[feeble]

I have came across a pre-clinical antiviral compound named Novir in Turkey which induced a remarkable remission on MS progress.It was given to 2 MS patients experiencing severe symptoms and the reason an anti-viral compound is used to treat an auto-immune disease is the fact that it is actually caused by a viral infection.At first it didnt make that sense to me since it is kind of hard anda bit "utopic" to expect such rapid results from a herbal antiviral drug.After trying to reach the Research team behind it I have found out that patent is owned by some guy named Erdal Can Alkoclar who is supposed to be the head of this very team.I have learned that the same ingredient with a slight modification to enhance tissue uptake and half-life is being purchased by many obsessive bodybuilders for its follistatin expression enhancing effects(it blocks myostatin).

as fas as I know his mail address is alkoclar@gmail.com.I hope this could be helpful for you my friend.

[Lufega]

I have came across a pre-clinical antiviral compound named Novir in Turkey which induced a remarkable remission on MS progress.It was given to 2 MS patients experiencing severe symptoms and the reason an anti-viral compound is used to treat an auto-immune disease is the fact that it is actually caused by a viral infection.At first it didnt make that sense to me since it is kind of hard anda bit "utopic" to expect such rapid results from a herbal antiviral drug.After trying to reach the Research team behind it I have found out that patent is owned by some guy named Erdal Can Alkoclar who is supposed to be the head of this very team.I have learned that the same ingredient with a slight modification to enhance tissue uptake and half-life is being purchased by many obsessive bodybuilders for its follistatin expression enhancing effects(it blocks myostatin).

as fas as I know his mail address is alkoclar@gmail.com.I hope this could be helpful for you my friend.

Where does one find this modified herbal compound? Curious George here.

[smithx]

N acetyl glucosamine would be a good thing to try:

UCI’s Dr. Michael Demetriou, Ani Grigorian and others found that oral N-acetylglucosamine (GlcNAc), which is similar to but more effective than the widely available glucosamine, inhibited the growth and function of abnormal T-cells that in MS incorrectly direct the immune system to attack and break down central nervous system tissue that insulates nerves.

http://today.uci.edu...r_ms_110930.php

In fact NAG is probably a good thing for anyone with any auto-immune disease to try.

Edited by smithx, 22 March 2012 - 11:25 PM.

[User]

Here are some of the research papers that I have come across while studying MS and supplements... To put it shortly:

Quercetin, Curcumin, Alpha Lipoic Acid, Vitamin D3, Ursolic Acid, NAG, Inosine, B12 (Methylcobalamin), Selenomethionine, Lion's Mane, Zinc

And not so shorty:



Mast Cells - Blood-Brain Barrier, cAMP, Histamine:

More Than Allergies: Histamine May Be a Possible Drug Target for Multiple Sclerosis
http://www.scienceda...10131133317.htm

Human mast cells stimulate activated T cells: implications for multiple sclerosis. (Th1, Th2, Luteolin)
http://www.ncbi.nlm....pubmed/19076366

Luteolin as a therapeutic option for multiple sclerosis. (Th1, Th2, Luteolin)
http://www.ncbi.nlm....pubmed/19825165

The mast cell and allergic diseases: role in pathogenesis and implications for therapy
http://onlinelibrary...07.02886.x/full

Inhibition of histamine turnover by 8-OH-DPAT, buspirone and 5-hydroxytryptophan in the mouse and rat brain (Histamine, 5-HTP)
http://www.springerl...28834q4743k14r/

Regulation of Human Mast Cell and Basophil Function by cAMP (cAMP, Histamine)
http://www.sciencedi...306362398000809

Migration of Multiple Sclerosis Lymphocytes Through Brain Endothelium
http://archneur.ama-...nt/59/3/391.pdf

Acute stress increases permeability of the blood–brain-barrier through activation of brain mast cells (BBB, Mast cell stabilizer)
http://www.sciencedi...006899300030262

Mast Cells Are Essential for Early Onset and Severe Disease in a Murine Model of Multiple Sclerosis
http://jem.rupress.o.../5/813.abstract

Mast cells: The immune gate to the brain (BBB)
http://www.sciencedi...02432059090129F

Critical role of mast cells in inflammatory diseases and the effect of acute stress (MS)
http://www.jni-journ...e/S0165-5728(03)00463-6/abstract

Mast cells: new targets for multiple sclerosis therapy?
http://www.jni-journ...e/S0165-5728(02)00250-3/abstract

Mechanisms underlying mast cell influence on EAE disease course
http://www.sciencedi...161589002000913

Corticotropin-Releasing Hormone and Brain Mast Cells Regulate Blood-Brain-Barrier Permeability Induced by Acute Stress (BBB, MS, Mast cell stabilizer)
http://jpet.aspetjou...03/3/1061.short

The mast cells of the multiple sclerosis brain (MS)
http://www.jni-journ...e/S0165-5728(96)00102-6/abstract

Kinetics of the inhibitory effect of flavonoids on histamine secretion from mast cells
http://www.springerl...4211h447537727/

Theanine is a candidate amino acid for pharmacological stabilization of mast cells.
http://www.ncbi.nlm....pubmed/21344174

Experimental Autoimmune Encephalomyelitis in NF-?B- Deficient Mice: Roles of NF-?B in the Activation and Differentiation of Autoreactive T Cells1
http://www.jimmunol....5/2937.abstract


Glial cells:

Astrocytes--friends or foes in multiple sclerosis? (MS)
http://www.ncbi.nlm....pubmed/17626262

Expression of MCP-1 by Reactive Astrocytes in Demyelinating Multiple Sclerosis Lesions (MS, BBB, MCP-1)
http://amjpathol.hig...stract/154/1/45

Astrocytes in multiple sclerosis: a product of their environment. (MS)
http://www.ncbi.nlm....pubmed/18516496


Leukotrienes - Curcumin:

Leukotrienes in the cerebrospinal fluid of multiple sclerosis patients (Leukotrienes, MS)
http://onlinelibrary...5491.x/abstract

Microarray analysis of gene expression in multiple sclerosis and EAE identifies 5-lipoxygenase as a component of inflammatory lesions (Leukotrienes, BBB, MS)
http://www.jni-journ...e/S0165-5728(01)00438-6/abstract

Corticosteroids as inhibitors of cysteinyl leukotriene metabolic and signaling pathways. (Leukotriene inhibitors, Corticosteroids)
http://www.ncbi.nlm....pubmed/18355910

Natural anti-inflammatory products and leukotriene inhibitors as complementary therapy for bronchial asthma (Leukotriene inhibitors, Curcumin)
http://www.ncbi.nlm....pubmed/20430018

The Effect of Curcumin on the Synthesis of Leukotriene B4: Phase II (Leukotriene inhibitors, Curcumin)
http://www.usc.edu/C...jects/S1419.pdf


Interleukin-6 - Quercetin and Curcumin:

Interleukin-6 is elevated in plasma in multiple sclerosis (MS, IL-6)
http://www.sciencedi...165572891900208

Interleukin-6 (IL-6)—A molecule with both beneficial and destructive potentials
http://www.sciencedi...30100829700021X

Interferon-beta sub 1b treatment decreases tumor necrosis factor-alpha and increases interleukin-6 production in multiple sclerosis (MS, IL-6, beta-IFN)
http://www.neurology...46/6/1633.short

Regulation of IL-1-induced selective IL-6 release from human mast cells and inhibition by quercetin (IL-1, IL-6, Quercetin)
http://onlinelibrary...jp.0706695/full

Physiological and pathological roles of interleukin-6 in the central nervous system (IL-6)
http://www.springerl...204h7200787452/

Quercetin 3-O-ß-(2?-galloyl)-glucopyranoside inhibits endotoxin LPS-induced IL-6 expression and NF-?B activation in macrophages (Quercetin, IL-6)
http://www.sciencedi...043466607003730

Administration of neutralizing antibodies to interleukin-6 (IL-6) reduces experimental autoimmune encephalomyelitis and is associated with elevated levels of IL-6 bioactivity in central nervous system and circulation.
http://www.ncbi.nlm....les/PMC2230023/

IL-6-Deficient Mice Are Resistant to Experimental Autoimmune Encephalomyelitis: Roles of IL-6 in the Activation and Differentiation of Autoreactive T Cells
http://www.jimmunol....1/12/6480.short

Proinflammatory cytokines regulate antigen-independent T-cell Activation by two separate calcium-signaling pathways in multiple sclerosis patients
http://onlinelibrary...430312/abstract

CURCUMIN AND AUTOIMMUNE DISEASE
http://www.springerl...r3177234q61k2v/


ROS, BBB - Alpha Lipoic Acid:

Possible New Target for Treatment of Multiple Sclerosis
http://www.scienceda...10327191157.htm

Lipoic acid in multiple sclerosis: a pilot study
http://msj.sagepub.c.../11/2/159.short

Alpha lipoic acid inhibits T cell migration into the spinal cord and suppresses and treats experimental autoimmune encephalomyelitis
http://www.jni-journ...e/S0165-5728(02)00269-2/abstract

a-Lipoic acid is effective in prevention and treatment of experimental autoimmune encephalomyelitis
http://www.jni-journ...e/S0165-5728(03)00514-9/abstract


Demyelination - Lion’s Mane mushroom, Narirutin, Hesperidin, DHEA:

The influence of Hericium erinaceus extract on myelination process in vitro
http://www.ncbi.nlm....pubmed/12675022

Nerve growth factor-inducing activity of Hericium erinaceus in 1321N1 human astrocytoma cell
http://www.ncbi.nlm....pubmed/18758067

Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial
http://www.ncbi.nlm....pubmed/18844328

http://www.nature.co...ll/nn.2702.html
Retinoid X receptor gamma signaling accelerates CNS remyelination

Administration of Chinpi, a Component of the Herbal Medicine Ninjin-Youei-To, Reverses Age-Induced Demyelination (Narirutin, Hesperidin)
http://www.hindawi.c...am/2011/617438/

Hesperidin
http://en.wikipedia....wiki/Hesperidin

Chemistry and pharmacology of the citrus bioflavonoid hesperidin
http://onlinelibrary...r.1074/abstract

Neurosteroids, with special reference to the effect of progesterone on myelination in peripheral nerves
http://msj.sagepub.c...t/3/2/105.short

Administration of Dehydroepiandrosterone Suppresses Experimental Allergic Encephalomyelitis in SJL/J Mice
http://www.jimmunol....7/12/7094.short


Methylcobalamin (B12):


Serum vitamin B12, folate, and homocysteine levels and their association with clinical and electrophysiological parameters in multiple sclerosis
http://www.sciencedi...967586808002622

Vitamin B12 metabolism and massive-dose methyl vitamin B12 therapy in Japanese patients with multiple sclerosis.
http://www.ncbi.nlm..../pubmed/8019047

Vitamin B12 metabolism in multiple sclerosis.
http://www.ncbi.nlm..../pubmed/1596201

Multiple sclerosis and vitamin B12 metabolism
http://www.sciencedi...16557289290137A

Vitamin B12, demyelination, remyelination and repair in multiple sclerosis
http://www.jns-journ...e/S0022-510X(05)00087-0/abstract

Methylcobalamin increases Erk1/2 and Akt activities through the methylation cycle and promotes nerve regeneration in a rat sciatic nerve injury model
http://www.sciencedi...01448860900510X


Vitamin D3:

Vitamin D and multiple sclerosis.
http://www.ncbi.nlm..../pubmed/9316607

Vitamin D intake and incidence of multiple sclerosis
http://www.neurology...t/62/1/60.short

Safety of vitamin D3 in adults with multiple sclerosis
http://www.ajcn.org/.../86/3/645.short

1,25-Dihydroxyvitamin D3 reversibly blocks the progression of relapsing encephalomyelitis, a model of multiple sclerosis
http://www.pnas.org/...3/15/7861.short

Vitamin D: a natural inhibitor of multiple sclerosis
http://journals.camb...line&aid=796900

Vitamin D and its role in immunology: Multiple sclerosis, and inflammatory bowel disease
http://www.sciencedi...079610706000034

Cytokine profile in patients with multiple sclerosis following vitamin D supplementation
http://www.jni-journ...e/S0165-5728(02)00396-X/abstract

A pilot study of oral calcitriol (1,25-dihydroxyvitamin D3) for relapsing–remitting multiple sclerosis
http://jnnp.bmj.com/...9/1294.abstract


Vitamin K:

Vitamin D toxicity redefined: Vitamin K and the molecular mechanism
http://www.medical-h...e/S0306-9877(06)00717-1/abstract


Fatique - Ginko Biloba, ALCAR, Creatine:

The Effect of Ginkgo Biloba on Functional Measures in Multiple Sclerosis: A Pilot Randomized Controlled Trial
http://www.explorejo...e/S1550-8307(05)00463-5/abstract

Disruption of Thiol Homeostasis and Nitrosative Stress in the Cerebrospinal Fluid of Patients with Active Multiple Sclerosis: Evidence for a Protective Role of Acetylcarnitine
http://www.springerl...1057130g766104/

Creatine supplementation reduces plasma levels of pro-inflammatory cytokines and PGE2 after a half-ironman competition
http://www.springerl...5k32g15001033h/

Prophylactic Creatine Administration Mediates Neuroprotection in Cerebral Ischemia in Mice
http://www.jneurosci...4/26/5909.short


Phosphodiesterase 3 and 4 - Quercetin, Genistein:

Decreased endocannabinoid levels in the brain and beneficial effects of agents activating cannabinoid and/or vanilloid receptors in a rat model of multiple sclerosis
http://www.sciencedi...969996105000756

Phosphodiesterase type IV inhibitors in the treatment of multiple sclerosis.
http://www.ncbi.nlm..../pubmed/9083927

Inhibitory effects of quercetin derivatives on phosphodiesterase isozymes and high-affinity [3 H ]-rolipram binding in guinea pig tissues
http://www.springerl...34155719518506/

Effects of flavonoids on cyclic AMP phosphodiesterase and lipid mobilization in rat adipocytes
http://www.sciencedi...00629529290531M

Pentoxifylline, a phosphodiesterase inhibitor, induces immune deviation in patients with multiple sclerosis
http://www.jni-journ...le/0165-5728(95)00176-X/abstract

Therapeutic Potential of Phosphodiesterase-4 and -3 Inhibitors in Th1-Mediated Autoimmune Diseases
http://www.jimmunol....64/2/1117.short

Drop in relapse rate of MS by combination therapy of three different phosphodiesterase inhibitors
http://msj.sagepub.c...nt/6/1/56.short

Ibudilast, a nonselective phosphodiesterase inhibitor, regulates Th1/Th2 balance and NKT cell subset in multiple sclerosis
http://msj.sagepub.c.../5/494.abstract

Phosphodiesterase 4 inhibitors reduce human dendritic cell inflammatory cytokine production and Th1-polarizing capacity
http://intimm.oxford.../7/827.abstract

cAMP-elevating agents suppress dendritic cell function
http://www.jleukbio..../6/903.abstract

Genistein
http://en.wikipedia.org/wiki/Genistein


Phosphodiesterase 5 inhibitor:

Viagra Could Reduce Multiple Sclerosis Symptoms, Study Suggests
http://www.scienceda...10519090354.htm

Horny Goat Weed
http://www.raysaheli...nygoatweed.html

Icariin
http://en.wikipedia.org/wiki/Icariin

Effects of icariin on phosphodiesterase-5 activity in vitro and cyclic guanosine monophosphate level in cavernous smooth muscle cells
http://www.goldjourn...e/S0090-4295(06)02155-8/abstract


NAG:

Control of T Cell-mediated Autoimmunity by Metabolite Flux to N-Glycan Biosynthesis
http://www.jbc.org/c...nt/282/27/20027

Genetics and the environment converge to dysregulate N-glycosylation in multiple sclerosis
http://www.nature.co...ncomms1333.html ***

N-Glycan Processing Deficiency Promotes Spontaneous Inflammatory Demyelination and Neurodegeneration
http://www.jbc.org/c.../33725.full.pdf


Peroxynitrites as a symptom - Scavenging with uric acid - Supplementation with Inosine 4*500 mg:

Uric acid, a natural scavenger of peroxynitrite, in experimental allergic encephalomyelitis and multiple?sclerosis
http://www.pnas.org/.../95/2/675.short

Uric acid
http://en.wikipedia.org/wiki/Uric_acid

Inosine
http://en.wikipedia.org/wiki/Inosine

Inactivation of peroxynitrite in multiple sclerosis patients after oral administration of inosine may suggest possible approaches to therapy of the disease.
http://www.ncbi.nlm....ubmed/11724447/

The treatment of multiple sclerosis with inosine.
http://www.ncbi.nlm....les/PMC3189001/ *

http://www.direct-ms...eUricAcidMS.pdf *

Nitric Oxide and Peroxynitrite in Health and Disease
http://physrev.physi...t/87/1/315.full **

Selenomethionine
http://en.wikipedia....elenomethionine

Protection against peroxynitrite by selenoproteins.
http://www.ncbi.nlm..../pubmed/9618937

Anti-inflammatory effects of inosine in human monocytes, neutrophils and epithelial cells in vitro
http://inotekcorp.co...f/ipcpub203.pdf

Multiple sclerosis: levels of interleukin-10-secreting blood mononuclear cells are low in untreated patients but augmented during interferon-beta-1b treatment.
http://www.ncbi.nlm....pubmed/10320650

Interleukin-10 polymorphisms in Spanish multiple sclerosis patients.
http://www.ncbi.nlm....pubmed/12458048


Endocannabinoids (Anandamide) - Daidzein, Maca (FAAH inhibitor):

Findings Suggest New Cause, Possible Treatment for Multiple Sclerosis
http://www.scienceda...10621093315.htm

Inhibition of the cellular uptake of anandamide by genistein and its analogue daidzein in cells with different levels of fatty acid amide hydrolase-driven uptake
http://onlinelibrary...jp.0707401/full

Biochanin A, a naturally occurring inhibitor of fatty acid amide hydrolase
http://onlinelibrary...10.00716.x/full

Inhibition of fatty acid amide hydrolase by kaempferol and related naturally occurring flavonoids
http://www.ncbi.nlm....les/PMC2538700/

Anti-inflammatory effects of daidzein on primary astroglial cell culture
http://www.ingentaco...000003/art00004

Immunomodulating Effects of Flavonoids on Acute and Chronic Inflammatory Responses Caused by Tumor Necrosis Factor a
http://www.ingentaco...000032/art00017

The 'specific' tyrosine kinase inhibitor genistein inhibits the enzymic hydrolysis of anandamide: implications for anandamide uptake.
http://lib.bioinfo.pl/pmid:17325653

Mass Spectrometric Determination of Genistein Tissue Distribution in Diet-Exposed Sprague-Dawley Rats1
http://jn.nutrition....30/8/1963.short

Reduction of body weight, liver steatosis and SCD1 expression by pharmacologic administration of the isoflavone daidzein in diet-induced obesity
http://www.researchg...induced_obesity

The Correlation Between Dietary Soy Phytoestrogens and Neuropathic Pain Behavior in Rats After Partial Denervation
http://www.anesthesi...t/94/2/421.full

Mechanism of Action of Lepidium meyenii (Maca): An Explanation for Its Neuroprotective Activity
http://www.ingentaco...000001/art00013


Th17 and IL-17 - Ursolic Acid, Apigenin, Artemisia annua, Resveratrol, Curcumin :

New Findings On Multiple Sclerosis: Immune Cells Also Attack Neurons Directly
http://www.scienceda...00923125113.htm

Compound Effectively Halts Progression of Multiple Sclerosis in Animal Model
http://www.scienceda...10418093846.htm

Interleukin-17 is a negative regulator of established allergic asthma
http://jem.rupress.o...2/2715.abstract


Interleukin-17 and Type 17 Helper T Cell
http://www.immunolog...EJM Miossec.pdf ***

Ursolic Acid Suppresses Interleukin-17 (IL-17) Production by Selectively Antagonizing the Function of ROR?t Protein*
http://www.jbc.org/c.../26/22707.short

Ursolic acid
http://en.wikipedia....ki/Ursolic_acid

Role of Interleukin-17 and the Neutrophil in Asthma
http://content.karge...ArtikelNr=49511

Interleukin-17 in fashion, at last: Ten years after its description, its cellular source has been identified
http://onlinelibrary.../art.22733/full

Inhibition of Interleukin-17 Prevents the Development of Arthritis in Vaccinated Mice Challenged with Borrelia burgdorferi
http://iai.asm.org/c...tract/71/6/3437

Periplocoside A prevents experimental autoimmune encephalomyelitis by suppressing IL-17 production and inhibits differentiation of Th17 cells
http://www.nature.co...ps2009101a.html

Topical anti-inflammatory activity of Salvia officinalis L. leaves: the relevance of ursolic acid
http://www.sciencedi...378874100003962

Variation of Ursolic Acid Content in Eight Ocimum Species from Northeastern Brazil
http://www.mdpi.com/...049/13/10/2482/

Ocimum tenuiflorum
http://en.wikipedia....mum_tenuiflorum

Ursolic Acid Attenuates D-Galactose-Induced Inflammatory Response in Mouse Prefrontal Cortex through Inhibiting AGEs/RAGE/NF-?B Pathway Activation
http://cercor.oxford...1/2540.abstract

Th17 and Allergy
http://ai.jsaweb.jp/...0121_index.html **

Apigenin, a non-mutagenic dietary flavonoid, suppresses lupus by inhibiting autoantigen presentation for expansion of autoreactive Th1 and Th17 cells.
http://www.ncbi.nlm....pubmed/19405952

Inducible nitric oxide synthase activation by interleukin-17
http://www.sciencedi...359610103000996

Th17 and Allergy
http://ai.jsaweb.jp/...0121_index.html **

T helper type 1 and 17 cells determine efficacy of interferon-ß in multiple sclerosis and experimental encephalomyelitis
http://www.nature.co...ll/nm.2110.html


The Role of Th17 in Neuroimmune Disorders: A Target for CAM Therapy. Part II **
http://downloads.hin...2011/548086.pdf

The Role of Th17 in Neuroimmune Disorders: A Target for CAM Therapy. Part III
http://www.hindawi.c...am/2011/548086/

Th17 Cell, the New Player of Neuroinflammatory Process in Multiple Sclerosis
http://onlinelibrary...11.02536.x/full **

Suppression of interleukin-17 by type I interferons: a contributing factor in virus-induced immunosuppression?
http://www.jle.com/e...D/article.phtml *

Regulatory role of resveratrol on Th17 in autoimmune disease
http://www.sciencedi...567576910002389 *

Curcumin has bright prospects for the treatment of multiple sclerosis
http://www.sciencedi...567576910002675


Low interleukin-10 (regulator of inflammation) as a symptom - cannabinol, garlic, tryptophan:

Allium sativum (garlic) suppresses leukocyte inflammatory cytokine production in vitro: Potential therapeutic use in the treatment of inflammatory bowel disease
http://onlinelibrary...cyto.10133/full

http://scholar.googl...s_ylo=&as_vis=0

http://www.anaturalh...es/Cytokine.pdf ***

Allicin inhibits SDF-1a-induced T cell interactions with fibronectin and endothelial cells by down-regulating cytoskeleton rearrangement, Pyk-2 phosphorylation and VLA-4 expression
http://www.ncbi.nlm....les/PMC1782446/

Anti-Inflammatory Effects of Antidepressants Through Suppression of the Interferon-[gamma]/Interleukin-10 Production Ratio
http://journals.lww....essants.12.aspx

Interferon beta induces interleukin-10 expression: Relevance to multiple sclerosis
http://onlinelibrary...400412/abstract

The effect of garlic consumption on Th1/Th2 cytokines in phytohemagglutinin (PHA) activated rat spleen lymphocytes
http://onlinelibrary...r.2700/abstract

Effect of Supplementation with Garlic Oil on Activity of Th1 and Th2 Lymphocytes from Rats
https://www.thieme-c.../s-0028-1088396 *

Systemic Production of IFN-a by Garlic (Allium Sativum) in Humans
http://www.lieberton...9/jir.2006.0124 *

Interferon alpha treatment of relapsing-remitting multiple sclerosis: long-term study of the correlations between clinical and magnetic resonance imaging results and effects on the immune function.
http://www.ncbi.nlm..../pubmed/9345396

Allium sativum (garlic) suppresses leukocyte inflammatory cytokine production in vitro: Potential therapeutic use in the treatment of inflammatory bowel disease
http://onlinelibrary...cyto.10133/full

Treatment of Autoimmune Neuroinflammation with a Synthetic Tryptophan Metabolite
http://www.sciencema.../5749/850.short

Interleukin-2, soluble interleukin-2-receptor, neopterin,l-tryptophan and ß2-microglobulin levels in CSF and serum of patients with relapsing-remitting or chronic-progressive multiple sclerosis
http://www.springerl...21384t71k85805/

Effects of L-tryptophan treatment on central indoleamine metabolism and short-lasting neurologic disturbances in multiple sclerosis
http://www.springerl...q2ww582548l467/


TH1/TH2 cell balance - Zinc

Effect of improved zinc status on T helper cell activation and TH1/TH2 ratio in healthy elderly individuals
http://www.springerl...08732141l4mlg5/


nf-Kb - Stinging nettle

High Hopes for New Therapy Method to Cure Multiple Sclerosis
http://news.softpedi...sis-32333.shtml

Plant extracts from stinging nettle (Urtica dioica), an antirheumatic remedy, inhibit the proinflammatory transcription factor NF-?B
http://www.sciencedi...014579398016226

Nettle extract (Urtica dioica) affects key receptors and enzymes associated with allergic rhinitis
http://onlinelibrary...r.2763/abstract

Multiple Sclerosis and Prostaglandin E2 Signaling
http://www.caymanche...vm/article/2161

Pharmacokinetic analysis of anti-allergy and anti-inflammation bioactives in a nettle (Urtica dioica) extract
http://www.herbalsci....com/pdf/10.pdf

Preventive and Therapeutic Effects of Plant Polyphenols through Suppression of Nuclear Factor-Kappa
http://naturalsupple..._factor-kap.pdf

Complementary and alternative medicine: Herbs, phytochemicals and vitamins and their immunologic effect
http://wao.confex.co...dout Part 2.pdf



COX-2 downregulation - (COX-2 upregulation downregulates IL-10 and upregulates IL-12, thus not wanted effect)

Specific Inhibition of Cyclooxygenase 2 Restores Antitumor Reactivity by Altering the Balance of IL-10 and IL-12 Synthesis1
http://www.jimmunol....164/1/361.short

Non-Small Cell Lung Cancer Cyclooxygenase-2-dependent Regulation of Cytokine Balance in Lymphocytes and Macrophages: Up-Regulation of Interleukin 10 and Down-Regulation of Interleukin 12 Production1
http://cancerres.aac...58/6/1208.short

[Luminosity]

I would not take the curcumin. It could be counter-productive. I would take healthy sources of fats, like fresh fish and avocados. I would avoid acidic foods and drink, wheat, and gluten. There are diets like that recommended for that illness. I would look into them.

[brunotto]

Long time studied (and used) for my psoriasis (autoimmune disease)... dont know if with MS can help.

http://www.longecity...riasis-regimen/

Also this...

http://wormtherapy.com/

[AdamI]

I think Curcumin still can be a good thing to take, since it is Anti-inflammatory and antioxidant.

Samento(Cat's claw herb liquid) has been shown to be very good against neuro diseases. And it's also anti-inflammatory. But then MS might be more of a autoimmune disease, then a neuro disease.
But as far as I know the symptoms of MS they do attack the neuro system such as one can't walk straight or at all and soo on until the neuro systems don't work at all.
In most studies they point to the "healing" of immune system in Cat's claw(Samento). Soo it might be good in healing the immunesystem? Works against Artritis anyway:
http://www.samento.c...m_oswalddoc.pdf

[Clarity]

My brother was just diagnosed. Our heads are spinning as we're trying to navigate thru the muriad of meds. I was wondering if something like Moducare (plant ligans) would help. It is suppose to balance TH1/TH2. I've taken it before and I have a sensitive system, and had no problems except possible lower estrogen. The only thing is, he has chronic infections - which doesn't make sense to me. Wouldn't he be in remission if his immune system was low?

[AdamI]

Here is some info on Telomerase activation and Multiple sclerosis (TA-65)

[victortsoi]

What would prevent MS in healthy individuals? Such a terrifying disease. I don't know what is worse, MS or the average cancer....
Do any of the popular supps we take on this forum INCREASE the risk?

[Clarity]

What would prevent MS in healthy individuals? Such a terrifying disease. I don't know what is worse, MS or the average cancer....
Do any of the popular supps we take on this forum INCREASE the risk?

I've been reading some about the nutrients important in MS - B12, Vit D, Thiamin, B complex. The only thing I have to relate to that is my brother was very low in B-12 and Vit. D (and he lives in the sunshine state - FL) prior to diagnosis. Some protocols I read call for keeping an MS patients Vit D as close to the high range as possible. So perhaps D status is part of the picture in prevention.

[Logic]

If there may be a viral component look into things that destroy the lipid layer on lipid coated virii.
Coconut oil, BHT.

[Clarity]

Does anyone know anything about low-dose naltrexone as a sole first line treatment? The doctors are insisting on Glilenya being the best drug to use in his situation. The problem is it has FDA warnings, one person died within 24 hrs of taking it, it slows down the heart, and my brother was shown to have an arrhythmia and a wide varying heart rate (35 to 131) on a holt monitor a couple years ago ( From his report: He has slight tachycardia and there were times of sinus bradycardia with a minimum heart rate of 35. There were eipisodes of sinus arrhythmia and also occasional premature atrial contractions). He's only 32 - I mentioned to my Mom about possible sleep apnea (don't think she's listening - she's overwhelmed), and they are talking doing this drug and giving him a pacemaker. Ridiculous.

[Werper]

Read up on Tysabri.

[xEva]

My brother was just diagnosed. ...The only thing is, he has chronic infections ...

Get rid of his chronic infections and his MS just may go away.

[User]

Does anyone know anything about low-dose naltrexone as a sole first line treatment? The doctors are insisting on Glilenya being the best drug to use in his situation. The problem is it has FDA warnings, one person died within 24 hrs of taking it, it slows down the heart, and my brother was shown to have an arrhythmia and a wide varying heart rate (35 to 131) on a holt monitor a couple years ago ( From his report: He has slight tachycardia and there were times of sinus bradycardia with a minimum heart rate of 35. There were eipisodes of sinus arrhythmia and also occasional premature atrial contractions). He's only 32 - I mentioned to my Mom about possible sleep apnea (don't think she's listening - she's overwhelmed), and they are talking doing this drug and giving him a pacemaker. Ridiculous.

I did some reading when I bumped in to low dose naltrexone treamentn. Nasty side effects were a turnoff. It seems that at naltrexone shares some of it's effects with curcumin, namely iNOS inhibition.


Low dose naltrexone therapy in multiple sclerosis
http://www.sciencedi...30698770400578X

Curcumin, An Atoxic Antioxidant and Natural NF?B, Cyclooxygenase-2, Lipooxygenase, and Inducible Nitric Oxide Synthase Inhibitor: A Shield Against Acute and Chronic Diseases
http://sppen.highwir...t/30/1/45.short

Differential regulation of CD4+ T helper cell responses by curcumin in experimental autoimmune encephalomyelitis
http://www.sciencedi...955286311002889

[Logic]

Human Herpies virus HHV-6 has been associated with MS:
http://www.ncbi.nlm..../pubmed/9396611
http://www.ncbi.nlm....pubmed/10738137
http://www.ncbi.nlm....pubmed/12436486

HHV-6 is a lipid coated virus.
The Lauric Acid in Coconut Oil breaks down this lipid layer which makes said virus unuble to infect cells and susceptible to being destoyed by ones own immine system.
BHT (butylated-hydroxytoluene) Seems to be even more effective at stripping away lipid layers. As it is oil soluble; mixing it with coconut oil seems like a good idea.

http://www.longecity...opic/42592-bht/

http://www.advance-h...com/herpes.html

Hopefully the above links are enough to get your interest enough to research this further yourself...

[User]

Human Herpies virus HHV-6 has been associated with MS:
http://www.ncbi.nlm..../pubmed/9396611
http://www.ncbi.nlm....pubmed/10738137
http://www.ncbi.nlm....pubmed/12436486

HHV-6 is a lipid coated virus.
The Lauric Acid in Coconut Oil breaks down this lipid layer which makes said virus unuble to infect cells and susceptible to being destoyed by ones own immine system.
BHT (butylated-hydroxytoluene) Seems to be even more effective at stripping away lipid layers. As it is oil soluble; mixing it with coconut oil seems like a good idea.

http://www.longecity...opic/42592-bht/

http://www.advance-h...com/herpes.html

Hopefully the above links are enough to get your interest enough to research this further yourself...

Interesting stuff. HHV-6 does indeed seem to be associated with MS but association is not causality. There is also an MS association with HHV-4 antibodies, measles antibodies, gluten antibodies and hereditary defects in glycosylation and vitamin D metabolism and other environmental factors. At this time, there doesn't seem to be enough information on what this association with HHVs and MS means:

http://www.ncbi.nlm....pubmed/20926836

For example, HHV might just transmit or flare more easily in humans whose immune system is not in balance. Many different approaches and substances seem to affect the disease progression, and as long as the picture is still unclear, one might benefit from a multi-pronged approach. Lauric acid has many beneficial effects, so it might be a good addition to a multi-pronged approach, but I can't find any studies that would have information on MS or EAE progression with lauric acid supplementation.

As you already pointed out, I would also recommend to read up on these yourself. Additionally I would recommend getting the person with the disease interested in the research themselves. They might not have the energy to do the reading themselves, but they have can give good feedback on what seems to be helping and what is not.

[niner]

HHV-6 is a lipid coated virus.
The Lauric Acid in Coconut Oil breaks down this lipid layer which makes said virus unuble to infect cells and susceptible to being destoyed by ones own immine system.
BHT (butylated-hydroxytoluene) Seems to be even more effective at stripping away lipid layers. As it is oil soluble; mixing it with coconut oil seems like a good idea.

I find it hard to believe that coconut oil taken orally would reach a high enough concentration at the site of the virus to kill it. I suppose it might do something for a cold sore, if applied topically. Is there any actual research on the use of coconut oil or BHT as an anti-herpetic in humans?

[Logic]

Interesting stuff. HHV-6 does indeed seem to be associated with MS but association is not causality. There is also an MS association with HHV-4 antibodies, measles antibodies, gluten antibodies and hereditary defects in glycosylation and vitamin D metabolism and other environmental factors. At this time, there doesn't seem to be enough information on what this association with HHVs and MS means:

http://www.ncbi.nlm....pubmed/20926836

For example, HHV might just transmit or flare more easily in humans whose immune system is not in balance. Many different approaches and substances seem to affect the disease progression, and as long as the picture is still unclear, one might benefit from a multi-pronged approach. Lauric acid has many beneficial effects, so it might be a good addition to a multi-pronged approach, but I can't find any studies that would have information on MS or EAE progression with lauric acid supplementation.

As you already pointed out, I would also recommend to read up on these yourself. Additionally I would recommend getting the person with the disease interested in the research themselves. They might not have the energy to do the reading themselves, but they have can give good feedback on what seems to be helping and what is not.

I quite agree that a multi pronged approach is best.
Off the top of my head I would use a good multi, high vit C, high vit D, Krill oil, circumin, Resveratrol, ...
As multiple infections in the 'patient' were mentioned; I would also look into the anti-pathogens mentioned on this site. Emodin and IP6 are interesting as they seem to be able to kill virii already inside infected cells.
I would certainly take EV Coconut oil as part of the protocol, but dont forget about the BHT mentioned.
Searching BHT MS brings up some intersting results.

There dont seem to be any studies on Coconut Oil working for Ms, but there does seem to be some showing it to be effective against another lipid coated virus: HIV/AIDS

http://www.ncbi.nlm....les/PMC2503967/
http://www.ncbi.nlm....pubmed/12349090
http://www.coconutoil.com/Dayrit.pdf

So certainly worth a try in someone with Multiple infections IMHO.

[shp5]

Hi,

my sister got diagnosed a few weeks ago, though tests are still running. Difficult disease which can vary from very subtle impedements to life crippling ones.

So, basics include Vitamins D3, B12 and Fish Oil. This seems pretty straigthforward.

As stress seems to be an important part on the disease, I wonder if the usual adaptogens might be a good idea too (jiaogulan, heshouwu, reishi, schizandra...)

[niner]

What supps could help with multiple sclerosis and why?

I'm thinking about curcumin, resveratrol, fish oil and a good multivitamin. Other ideas?

C60-olive oil. MS is an autoimmune-driven demyelination syndrome. The damaging autoimmune processes ultimately involve free radicals, primarily in the form of reactive oxygen species. Myelin is predominantly lipid, with the main lipid component being galactocerebroside, which is physically similar to fatty acids. These facts provide a framework for a treatment strategy: C60 voraciously detoxifies reactive oxygen species, and when reacted with vegetable oils, forms a compound in which C60 is linked to a fatty acid. This compound is attracted to the fatty acids in membranes, and would also be expected to be attracted to the sphingolipids in myelin. We have literature evidence that C60 is helpful with out-of-control immune responses, and there has been an anecdotal report in the C60health forum that a person with MS saw their balance improve after a low dose of C60-olive oil. Curcumin, resveratrol, fish oil and a multi are all reasonable things to try, but I don't think any of them will help MS in a significant way. I think C60-oo has a fairly good chance of helping.

[Clarity]

Niner: Olive Oil is good stuff. I've been taking a tablespoon at night, I have adrenal, glucose and possible thyroid problems - it just makes me feel so much better. When I keep up with it, it gets rid of my joint pain.

I don't know about viral triggers regarding my brother, but he does have syringomyelia - a syrinx in his spinal cord. It has been stable for a long time. But maybe it has affected spinal/brain circulation, making MS more likely?

I was reading some studies about this upcoming drug BG-12. I read that it is fumaric acid (or Dimethyl fumarate as they call it). It has shown to reduce relapse by 50% with few serious side effects (of course it's a synthetic now, and that will happen). My question is, there are fumaric acids in supplement form. Would they work the same possibly?

[niner]

Niner: Olive Oil is good stuff. I've been taking a tablespoon at night, I have adrenal, glucose and possible thyroid problems - it just makes me feel so much better. When I keep up with it, it gets rid of my joint pain.

I don't know about viral triggers regarding my brother, but he does have syringomyelia - a syrinx in his spinal cord. It has been stable for a long time. But maybe it has affected spinal/brain circulation, making MS more likely?

I was reading some studies about this upcoming drug BG-12. I read that it is fumaric acid (or Dimethyl fumarate as they call it). It has shown to reduce relapse by 50% with few serious side effects (of course it's a synthetic now, and that will happen). My question is, there are fumaric acids in supplement form. Would they work the same possibly?

I agree that olive oil is good, but C60-olive oil is something else entirely. It is olive oil that's been reacted with a particular form of carbon known as "C60" also called fullerenes or buckyballs. (Named after Buckminster Fuller) This combination first came to the world's attention after it was found to increase the lifespan of Wistar rats by 90%. Since that discovery, there has been a lot of interest in it here, which is collected in the c60health forum. We've found it to be profoundly helpful for people with compromised oxygenation or mitochondrial issues, allergy, and inflammation. There are two sources on the net, one in the US and one in the EU. Details are in a couple different threads in the above forum, or you could find them with google. (this is the US site)

BG-12 looks good. I presume it will be approved relatively quickly. Dimethyl fumarate is quite different from fumaric acid, however. I wouldn't expect them to act the same. You might be able to find dimethyl fumarate on the net. It's been used as a drug in Europe for some other purpose, and has also been used as an anti-microbial.