50 replies to this topic

[Lufega]

Look into pharmacological doses of melatonin.  Seeing as melatonin inhibits tumor growth and can get into every nook and cranny in the body including permeating mitochondrial membranes, it seems like it a good idea to prioritize this in your arsenal.  It's also used to prevent/reduce the onset of neuropathy in cancer patients receiving chemo, without affecting the effectiveness of the treatment.

Quote

Evidence indicates that melatonin's anticancer effects are exerted via inhibition of cell proliferation and a stimulation of differentiation and apoptosis. A new mechanism by which physiological and pharmacological blood levels of melatonin inhibit cancer growth in vivois via a melatonin-induced suppression of tumor linoleic acid (LA) uptake and its metabolism to the important mitogenic signaling molecule 13-hydroxyoctadecadienoic acid (13-HODE). Melatonin suppresses cAMP formation and inhibits tumor uptake of LA and its metabolism to 13-HODE via a melatonin receptor-mediated mechanism in both tissue-isolated rat hepatoma 7288 CTC and human breast cancer xenografts. PMID:16217131

[brunotto]

Melatonin is a TH1 immunostimulator... very bad for Th1 autoimmune conditions... very good for fighting cancer or also virus (but it creates also inflammation).

[Rolf]

Thanks everyone for helping out! I´ve been quite busy on the sidelines, but have read and considered all your contributions and will respond to all of them seperately, hopefully soon.

@ Lufega & brunotto: my father is currently on 1.5 mcg of melatonin. I find this a maximum dose to stay away from sleeping disturbance. Would you think there are already benefits to be expected at the current dose, or would you raise further (6mcg - 4 fold seems clinical dose).

Also, @ brunotto: would you know at what dose melatonin could significantly increase T cell activation? This sounds VERY interesting - as many of anti-melanoma phytochemicals (ECGC, curcumin, etc) seem to act as immunosuppressors rather than stimulators...(!)

[hippocampus]

you probably meant 1,5 mg, not mcg

[Rolf]

hippocampus, on 04 May 2012 - 07:23 PM, said:

you probably meant 1,5 mg, not mcg

Pardon me, exactly - been posting a bit too much about vitamin D lately...

[Lufega]

As that study I linked mentioned, they used pharmacological doses.  For example, I'm titatring up to 20 mg for peripheral nerve regeneration.  I'm currently at 15 mg with no disruption in sleep. Quite the contrary, I sleep very well and wake up feeling refreshed at first light.  I missed my dose a couple of times and noticed no interruption in sleeping patterns.  Additionally, I'm naturally becoming tired and sundown even before I take the next dose.

[joelcairo]

Therapeutic doses are 10, 20, even 40 mg. See the trials reported in this article. FWIW, they were all conducted by the same researcher, and I have not investigated his or her credibility.
http://www.lef.org/m...elatonin_02.htm

[stponky]

In addition to Zelboraf, metformin might also be useful. It is really cheap and apparently works against melanoma.

"Metformin inhibits melanoma development through autophagy and apoptosis mechanisms"

From http://www.nature.co...dis201186a.html

Edited by stponky, 05 May 2012 - 12:34 AM.

[brunotto]

Yes, having Psoriasis melatonine is totally forbidden for me, but there are different opinions about (look below).
I'll think about using: Celecoxib + Fluvastatin (also a Th1 supporter)

You need of course medical support tfor you father o take both.... important checking INR. Celecoxib has some stroke risiko.

Influence of melatonin and its precursor L-tryptophan on Th1 dependent contact hypersensitivity

There is strong evidence that melatonin possesses immunomodulatory activity. It has been shown that it enhances the immune response, acting as a pro-inflammatory agent. It is suggested that melatonin promotes Th1-mediated immune responses by upregulating IL-12 production by antigen presenting cells. In contrast, it has also been shown that melatonin can inhibit Th1 immunity and instead promote a Th2 response. This discrepancy between different observations of the regulatory activity of melatonin on Th1 immunity encouraged us to further investigate the influence of melatonin and its precursor L-tryptophan on Th1 mediated contact hypersensitivity (CHS). Our results show that both melatonin and L-tryptophan inhibit the inflammatory response associated with CHS. Melatonin inhibited the Th1-dependent immune response by suppressing the production of IFN-gamma and IL-12 by cells in the lymph node. On the other hand treatment with L-tryptophan inhibits CHS without affecting INF-gamma production by Th1 effector cells. Observed suppression of CHS after L-tryptophan treatment is at least partly through the production of the anti-inflammatory cytokine IL-10.

http://www.ncbi.nlm....pubmed/18212406

[brunotto]

Also Mebendazole...

http://www.longecity...y-kills-cancer/

[Godot]

I'd go on a near-zero carb diet and supplement with raspberry ketones to lower blood glucose.

I'd go for a much higher dose of D3 - maybe 10,000 IU daily.

Melatonin sounds very promising, as does mebendazole (if you can figure out how to get some).

I'd definitely take a goodly dose of quercetin since it encourages melanoma cell apoptosis
http://www.ncbi.nlm....pubmed/15538571
and sensitizes melanoma to the most common chemotherapy
http://www.ncbi.nlm....pubmed/20540768
and shows general antiproliferative effects against cancers
http://ar.iiarjourna...6/2A/1177.short

And I'd add in some sulforaphane
http://www.spandidos...com/etm/1/6/915

as well as apigenin
http://findarticles...._5/ai_68727260/

Lastly, I don't think there;s enough evidence for me to recommend this, but if it were me, I'd take methylene blue
http://books.google....elanoma&f=false
At least it's well-tolerated and the risk is low, and in combination with the other metabolic challenges I'd be presenting the melanoma, I think it would have a chance of being effective.

Edited by David Godot, 05 May 2012 - 11:01 PM.

[Godot]

I came across this interesting article on LEF - http://www.lef.org/p...rtcl-027d.shtml

Which would prompt me to add lactoferrin, glutamine, and inositol to my above regimen.

[joelcairo]

Also research high-quality supplements of Propolis/CAPE, cinnamon, ginger, and SAMC/aged garlic. Medicinal mushrooms/fungi such as reishi, shiitake, maitake and chaga. Statin drugs and Celebrex are relatively inexpensive and easy to get prescriptons for, as they're common preventative medicines for older men anyway. Gamma tocotrienol is an interesting supplement that synergizes with a lot of good things. And lots of green tea (EGCG), black tea (theaflavins) and coffee.

[joelcairo]

P.S. Has the primary skin cancer been removed yet? Probably yes, but if not there is an ingenious therapy I have read about where an immune-stimulating cream (Imiquimod) is applied topically for a week or two, and at the end of that time then the tumor is blasted with (I think) laser light. The damaged and dying cells trigger an enormous immune reaction, in which T cells become activated with the exact antigens that this specific melanoma expresses. This protocol essentially vaccinates the patient against the exact cancer attacking their body. It cleared all metastases from 2 out of 2 patients in this trial.
http://www.thedcasit...or_melanoma.pdf

This is an attractive option because melanoma is relatively insensitive to radiation and chemo therapies, but is vulnerable to immune attack. See also Yervoy and IL-2. It would be beautiful if something like this could tried with tumors growing inside the body. I don't see any obvious problem, other than getting access, but I have never heard of it being attempted.

ALTERNATIVELY, if there is no melanoma on the skin, there is another protocol which is a lot less specific and hasn't been proven in humans, but might be safe enough to try. Use the same immune-stimulating cream Imiquimod to a region of skin and then apply the skin-depigmenting agent Monobenzone. This can create generalized immunity to melanocytes and again trigger immune defenses to metastatic tumors. The side effect of this is vitiligo (Michael Jackson disease). File this under "might be just crazy enough to work".
http://www.plosone.o...al.pone.0010626

[Logic]

Thx David Godot & Brunotto  for mentionomg Mebendazole;  its nice to have a bit of recognition for my research.

@ Rolf:
I am in South Africa and will be happy to have a look for this and send it if you wish.

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Although this:
http://www.viewzone.com/eggplant.html
Does not seem to work for melanoma;  it may still be of value.

[Logic]

I have not yet read any of this, so dont know if its worth anything: (which is pretty much the same as having read it in my case! )
http://www.ncbi.nlm....istletoe cancer

[ta5]

Just some ideas...
IP6
IP6+Pterostilbene
Pterostilbene+Quercetin
Selenomethionine
Sulforaphane or Broccoli
Glycine, BCAAs, others
Tyrosine and Phenylalanine Restriction
Methionine Restriction
Cordyceps
Aspirin?
Tocopherols
Tocotrienols
PQQ
Retinoids? Lots of studies, didn't sort them out.
Azelaic acid
Glycolic acid
Ascorbate

[niner]

David Godot, on 05 May 2012 - 10:59 PM, said:

Lastly, I don't think there;s enough evidence for me to recommend this, but if it were me, I'd take methylene blue
http://books.google....elanoma&f=false
At least it's well-tolerated and the risk is low, and in combination with the other metabolic challenges I'd be presenting the melanoma, I think it would have a chance of being effective.

Ordinary MB is low risk (be aware of MAOI effects at high dosages), probably wouldn't hurt, and might even help a little, but the work mentioned in the book chapter linked here involves radioactive MB (Astatine labeled), which is a horse of a different color.

[Godot]

Ah, yes, I see that you're correct.

[Psychonaut]

Arska briefly mentioned cannabanoids, personally the first thing I would do is work out how I am going to get my hands on hemp/cannabis oil. There is a lot of anecdotal evidence (endless amounts online(youtube)) on the potential of concentrated cannabis oil to treat and potentially reverse cancer, especially used topically for skin cancers.

This listed company has reported some initial successes early April with cancer patients,

http://www.cannabiss...s-releases.html

The practicality of getting several pounds of quality material to turn into oil is the difficult part, but when you are talking life and death who cares about the legality of it. Even if it turns out to not be helpful you still end up with something that is going to be far better than anything you can get legally for pain management.

Edited by Psychonaut, 08 May 2012 - 02:34 PM.

[Laura Johnson]

hi rolf....
there hasnt been any action on this blog for a while..... i hope it means that you father is well.
just for your information...
i have melanoma and i have been removing it with black salve,,,
www.altcancer.com
its been 2 years now and i thought it was about time i did something on the inside just in case... so i found percys powder..
http://www.health-se...stimonials.html
and i also started taking a tonic from altcancer....
http://www.altcancer...azon-tonic.html
plus from the start i found the blood type diet...
www.damao.com
i hope all is well with you and your dad.... ;-))