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[treonsverdery]

Optimizing HAR approach to superlongevity

Humans live longer than other primates
A researcher looked at all the human genes as well as primate genes to see which had the greatest velocity of change between humans to primates These are called human accelerated regions (HAR).http://www.scientifi...s-identify-gene There are people that believe these rapidly changing genes HAR that made the most differences between humans n primates code humans notable abilities like greater intelligence as well as longer life along with Neoteny, the way humans look juvenile with large heads, small brows. Genetic neoteny could represent a partial change of a prograamed lifecycle to be at a young style of body longer, which goes with actual chronological durability, longevity. Very simplistically, neoteny applied to primates is something like the dauer effect.

So a theory of longevity, as well as a technology would be to find those genes that changed the most between primates n humans, then give them to rats to see if the rats become cleverer, longer lived, or differently emotive. If they find that the HAR human genes most changed from primates actually cause longevity then people will know about a new specific longevity gene that effects humans

Then with the rats they can create variations of the HAR longevity gene doing things like swapping cycteine with methionine or alanine with phenylalanine to find protein expression of new genes that make the rats live even longer. Transferring these superlongevity tested artificial genes to humans then causes humans to live longer.

so its a longevity theory rather than an aging theory, rather than seek a repairable, it finds a longevity physiology architecture. Actual researchers may find this area particularly focused as well as effective as of 40,000 genes, the 49 HAR genes approximate just a thousandth of the gene space yet more than double lifespan


So if a researcher binges on HAR genes to find the mechanisms of human superlongevity They could be called HARbingers of awesome. I actually wrote to Dr. Pollards lab, she did the first HAR research, to see if the feel like being harbingers of awesome.

Edited by treonsverdery, 20 April 2012 - 07:27 PM.

[treonsverdery]

Dr. Pollard as well as other researchers are (to my perception) enthusiastic about the way the Highly Acclerated Regions (HAR) also happen to frequently be regulatory to protein coding genes, notably genes that cause illness. Thus figuring out HAR likely cures diseases. Its my thought that neoteny, which is the extended juvenilization of an organisms form strongly defers disease. Notably a mouse lives its entire life, even becoming white haired, prior to a human reaching puberty. So lengthening the time to maturation of an organism is viewable as an approach to deferring or curing disease.